Reduced baroreceptor reflex control of heart rate in chronic renal failure

慢性肾功能衰竭患者心率的压力感受器反射控制减弱

• 批准号: nhmrc : 1030301
• 负责人: A/Pr Ann Goodchild
• 金额: $ 32.69万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/reduced-baroreceptor-reflex-renal-failure/110747
• 关键词: Reduced; baroreceptor; reflex; control; heart

People with kidney disease are more likely to die of heart disease than their ailing kidneys. One reason is because their hearts do not respond properly to changes in blood pressure, as the nerve circuits controlling the heart become dysfunctional. We will examine where and why components of this circuit are unable to respond to changes in blood pressure. This will help guide new treatments to reduce the incidence of heart disease and risk of death associated with kidney disease.

患有肾脏疾病的人比生病的肾脏更有可能死于心脏病。原因之一是因为他们的心脏对血压的变化没有适当的反应，因为控制心脏的神经回路变得功能失调。我们将研究该电路的组成部分在哪里以及为什么无法应对血压变化。这将有助于指导新的治疗方法，以减少与肾脏疾病有关的心脏病的发生和死亡的风险。