Dynamic Links Between Risk Factors, Substance Use, and Consequences: Ages 18-35

风险因素、药物使用和后果之间的动态联系：18-35 岁

• 批准号: 9023522
• 负责人: Megan E. Patrick
• 金额: $ 35.33万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9023522
• 关键词: Accounting; Acute; Address; Adolescent; Adult; Age; Alcohol consumption; Alcohol or Other Drugs use; Alcohols; Behavior; Behavioral; Birth; Chronic; Cognitive; Collaborations; Confounding Factors (Epidemiology); Data; Development; Drug usage; Drug user; Employment; Epidemiology; Ethnic Origin; Etiology; Frequencies; Future; Gender; Health; Health Status; Individual; Intervention; Left; Life Cycle Stages; Link; Long-Term Effects; Marijuana; Marriage; Mediating; Mental Health; Methodology; Methods; Modeling; Monitor; Outcome; Parenting Education; Pathway interactions; Pharmaceutical Preparations; Policies; Population; Public Health; Race; Research; Research Personnel; Resources; Risk; Risk Behaviors; Risk Factors; Role; Sampling; Social Environment; Statistical Methods; Subgroup; Substance Use Disorder; Symptoms; Techniques; Testing; Time; Tobacco; United States National Institutes of Health; Variant; Weight; base; behavior change; binge drinking; cohort; college; demographics; follow-up; innovation; interest; intervention program; marijuana use; person centered; sex risk; theories; therapy development; twelfth grade; young adult

DESCRIPTION (provided by applicant): Substance use has acute and chronic detrimental impacts on public health. However, risk for use is not conferred equally across the population, the life course, or birth cohorts. Central questions about when and for whom risk factors are most important in contributing to substance use (tobacco, alcohol, marijuana, and other drug use) in young adulthood (YA) remain unanswered, including the extent to which substance use in YA leads to adult health consequences such as substance use disorders (SUDs), sexual risk behaviors, and physical/mental health deficits. Based on a life course perspective, this project will move the field toward examining developmental changes in the salience of risk factors across the life course and toward documenting the mechanisms through which long-term substance use consequences emerge. We will use national panel data from 38 high school senior year cohorts (1976 to 2013), with specific emphasis on 20 cohorts of individuals with longitudinal data across ages 18 to 35 (N~24,000) from Monitoring the Future (MTF) to examine significant unanswered questions regarding adolescent and YA substance use behaviors and adult health outcomes. Leading-edge statistical methods applied to MTF data will be used to model the dynamic associations between risk factors and risk behaviors across YA, and the extent to which these behaviors predict adult health consequences. Aim 1 will examine questions regarding developmental changes in the epidemiology and etiology of substance use across ages, cohorts, social role statuses, and demographic subgroups. Questions include the extent to which the links between cognitive/attitudinal risk factors and substance use behaviors change with age. Aim 2 will examine the long-term consequences of YA substance use on the acquisition and timing of social role statuses and health into adulthood. For example, we will examine the extent to which social roles mediate the effect of YA substance use on adult health consequences. Aim 3 will focus on disseminating new and advanced methodological techniques for examining risk factors, behaviors, and consequences to public health researchers. Results will advance our understanding of substance use behaviors with critical health impacts, and will inform the development of interventions that take into account individual behaviors, risk factors, and social roles to find strategies for reducing the negative consequences of drug use in young adulthood.

描述（由申请人提供）：药物使用对公共健康有急性和慢性的有害影响。然而，不同人群、生命历程或出生群体的使用风险并不相同。关于危险因素何时以及对谁来说对成年早期 (YA) 物质使用（烟草、酒精、大麻和其他药物使用）最重要的核心问题仍未得到解答，包括青年期物质使用导致成人的程度健康后果，例如物质使用障碍 (SUD)、危险性行为和身体/心理健康缺陷。基于生命历程的视角，该项目将推动该领域研究生命历程中风险因素显着性的发展变化，并记录长期药物使用后果出现的机制。我们将使用来自 38 个高中高年级群体（1976 年至 2013 年）的全国面板数据，特别重点关注来自监测未来 (MTF) 的 20 个年龄在 18 至 35 岁之间（N~24,000）的个体队列数据，以检验显着性有关青少年和青少年药物使用行为和成人健康结果的未解答问题。应用于 MTF 数据的前沿统计方法将用于对整个青少年年的风险因素和风险行为之间的动态关联进行建模，以及这些行为预测成人健康后果的程度。目标 1 将研究有关跨年龄、群体、社会角色状态和人口亚组的物质使用流行病学和病因学发展变化的问题。问题包括认知/态度风险因素与物质使用行为之间的联系随着年龄的增长而变化的程度。目标 2 将研究青少年物质使用对成年期社会角色地位和健康的获得和时间安排的长期影响。例如，我们将研究社会角色在多大程度上介导青少年物质使用对成人健康后果的影响。目标 3 将侧重于向公共卫生研究人员传播用于检查风险因素、行为和后果的新的先进方法技术。研究结果将增进我们对对健康产生重大影响的物质使用行为的理解，并将为制定干预措施提供信息，这些干预措施考虑到个人行为、风险因素和社会角色，以找到减少青少年吸毒负面后果的策略。