LAMb Request for Ventilated Cage Racks

LAMb 要求通风笼架

• 批准号: 9211727
• 负责人: STEVEN H GRAHAM
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2016-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9211727
• 关键词: Address; Air; Animal Disease Models; Animal Experimentation; Animal Husbandry; Animal Model; Animals; Applications Grants; Area; Arts; Back; Biomedical Research; Caring; Communicable Diseases; Contracts; Diagnosis; Dimensions; Discipline of Nursing; Disease; Ensure; Environment; Environmental air flow; Equipment; Funding; General Population; Goals; Health; Healthcare Systems; House mice; Housing; Human Resources; Humidity; Investments; Laboratory Animal Production and Facilities; Laboratory Personnel; Laboratory Research; Lead; Lung diseases; Malignant Neoplasms; Manufacturer Name; Marketing; Medical; Minor; Mus; Physiology; Procedures; Rattus; Research; Research Personnel; Rodent; Sepsis; Stroke; System; United States National Institutes of Health; Universities; Veterans; Work; air filter; animal facility; bone; cost; design; disease transmission; equipment acquisition; exhaust; improved; in vivo; programs

In vivo animal studies are essential to VA-funded research conducted at VA Pittsburgh Healthcare System. The Aim of this proposal is to obtain funds to purchase ventilated cage racks needed to provide husbandry compliant with regulatory specifications and state-of-the-art biocontainment for housing rodents at the new Animal Research Facility (ARF). The integrated cage systems have unique specifications including racks mounted on Ecoflo blowers, HEPA air filters at low velocity that maintain a stable environment, exhaust plenums that remain negative to the room minimizing that contaminated air is released to the room, and smaller footprints with increased housing capacity. The requested cages are compatible with the room dimensions and exhaust system of the new facility. Currently, 10 VA and NIH funded investigators house their research animals in the VA facility, which is a converted 1950s nursing quarters that lacks many capabilities and features needed to conduct state-of-the-art animal research. Due to the inadequacy of the current ARF, 8 additional investigators conduct animal studies at the University of Pittsburgh through a contract with the affiliate. With the completion of the new ARF and the installation of modern, state of the art caging systems, we anticipate that investigators who currently house their animals at the University of Pittsburgh will move their animals back to the VA. Thus, purchase of these cages represents a long-term investment aimed at retaining existing and funded VA investigators and attracting new VA investigators by enhancing the animal husbandry quality and capabilities of our Animal Research Facility.

体内动物研究对于 VA 资助的在 VA 匹兹堡进行的研​​究至关重要 医疗保健系统。该提案的目的是获得资金购买通风笼 提供符合监管规范和最先进的畜牧业所需的货架 新动物研究设施 (ARF) 中的啮齿类动物生物防护。集成的 笼式系统具有独特的规格，包括安装在 Ecoflo 鼓风机、HEPA 空气上的机架 低速过滤器可维持稳定的环境，排气室保持负压 到房间，最大限度地减少被污染的空气释放到房间，并且占地面积更小 增加住房容量。要求的笼子与房间尺寸兼容 和新设施的排气系统。目前，有 10 家 VA 和 NIH 资助研究人员入住 他们在 VA 设施中进行研究动物，该设施是由 20 世纪 50 年代的护理宿舍改建而成，缺乏 进行最先进的动物研究所需的许多功能和特性。由于 由于当前 ARF 的不足，另外 8 名研究人员在该实验室进行动物研究 匹兹堡大学通过与附属机构签订合同。随着新ARF的完成 以及安装现代、最先进的笼养系统，我们预计调查人员 目前在匹兹堡大学饲养动物的人将把他们的动物搬回 弗吉尼亚州。因此，购买这些笼子是一项长期投资，旨在保留 现有和资助的 VA 调查员，并通过加强 我们动物研究设施的畜牧质量和能力。