Limited Competition for the Continuation of the SEARCH for Diabetes in Youth Cohort Study (UC4)SEARCH for Diabetes in Youth Cohort Study

继续进行青少年糖尿病研究 (UC4) 青少年糖尿病研究的有限竞争

基本信息

批准号：
9343335
负责人：
Ralph B. DAgostino
金额：
$ 79.76万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-25 至 2020-08-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): SEARCH for Diabetes in Youth (SEARCH) is an on-going, large, culturally diverse, multi-center and population-based epidemiological study of youth with diabetes. Initiated in 2000 and encompassing the major racial/ethnic groups in the U.S: non-Hispanic white, African-American, Hispanic, Asian-Pacific Islander, and American Indian, SEARCH was designed to estimate the prevalence, incidence and clinical presentation of diabetes in youth age < 20 years, by age, sex, race/ethnicity and diabetes type (SEARCH Registry Study). Beginning in 2002, SEARCH recruited a series of incident cohorts representative of the diverse racial/ethnic, socioeconomic and geographic base population, who were well-characterized through a variety of surveys, physical and laboratory assessments soon after diagnosis and followed them longitudinally (SEARCH Cohort Study). This proposal will continue longitudinal follow-up of the participants in the SEARCH Cohort Study to examine four Specific Aims: 1) To establish, compare and contrast the burden (prevalence, incidence, progression and clustering) of acute and chronic complications of diabetes, and explore the responsible risk factors and pathways among youth and young adults with type 1 and type 2 diabetes, 2) To explore, compare and contrast processes of care (including barriers to care and quality of care) and their influence on quality of life among youth with type 1 and type 2 diabetes, as they transition from pediatric to adult care, 3) to conduct surveillance of mortality including cause of death in the SEARCH cohort, and 4) to maintain, supplement and promote access to the SEARCH Cohort repository for biological specimens to conduct scientifically and logistically appropriate ancillary studies. Since there is an earlier onset and increasing rate of both type 1 and type 2 diabetes, the already high burden of diabetes to the individual and the nation will increase over time. Understanding the factors and pathways that contribute to this burden will provide the foundation to develop strategic interventions to limit individual morbidity and mortality and promote an effective, sustainable national health policy.

描述（由申请人提供）：青少年糖尿病研究 (SEARCH) 是一项持续的、大规模的、文化多元化的、多中心的、以人群为基础的青少年糖尿病流行病学研究，涵盖主要种族/民族。美国的群体：非西班牙裔白人、非裔美国人、西班牙裔、亚太岛民和美洲印第安人，SEARCH 旨在估计患病率、发病率按年龄、性别、种族/民族和糖尿病类型划分的 20 岁以下青少年糖尿病的临床表现（SEARCH 登记研究），从 2002 年开始，SEARCH 招募了一系列代表不同种族/民族、社会经济和糖尿病的事件队列。地理基础人群，在诊断后不久通过各种调查、身体和实验室评估对其进行了充分的表征，并对其进行了纵向跟踪（搜索队列研究）。该提案将继续对参与者进行纵向跟踪。搜索队列研究旨在检查四个具体目标： 1) 建立、比较和对比糖尿病急性和慢性并发症的负担（患病率、发生率、进展和聚类），并探索青少年和年轻人中的危险因素和途径。 1 型和 2 型糖尿病，2) 探索、比较和对比护理过程（包括护理障碍和护理质量）及其对患有 1 型和 2 型糖尿病的青少年从儿科过渡时的生活质量的影响到成人护理， 3) 对 SEARCH 队列中的死亡率（包括死亡原因）进行监测，以及 4) 维护、补充和促进对 SEARCH 队列存储库的生物样本的访问，以便在科学和后勤上进行适当的辅助研究，因为存在较早的发病和后勤保障。随着 1 型和 2 型糖尿病发病率的增加，糖尿病给个人和国家带来的沉重负担将随着时间的推移而增加，了解造成这种负担的因素和途径将为制定战略干预措施以限制个人提供基础。发病率和死亡率，并促进有效、可持续的国家卫生政策。