TDCS and Cognitive Retraining to Augment Pharmacotherapy for the Treatment of Nicotine Dependence

TDCS 和认知再训练增强药物治疗尼古丁依赖

基本信息

批准号：
9037634
负责人：
Eric D Claus
金额：
$ 22.09万
依托单位：
THE MIND RESEARCH NETWORK
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-04-01 至 2018-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9037634
关键词：
Abstinence Aftercare Anterior Avoidance Learning Behavior Control Brain Brain region Cephalic Cigarette Corpus striatum structure Cues Data Development Dorsal Double-Blind Method Effectiveness Health Impairment Impulsivity Incentives Individual Insula of Reil Intervention Investigation Lateral Lead Learning Measures Methods Motivation Neurocognitive Nicotine Nicotine Dependence Outcome Participant Patients Pharmaceutical Preparations Pharmacotherapy Placebos Prefrontal Cortex Procedures Protocols documentation Psychiatric therapeutic procedure Public Health Regimen Relapse Research Risk-Taking Smoke Smoker Smoking Stimulus Substance Addiction Substance Use Disorder Substance of Abuse Techniques Testing Tobacco Tobacco use Training Technics Work addiction approach behavior attentional bias behavior influence cigarette smoking cingulate cortex cognitive control cognitive retraining craving design drug of abuse experience follow-up improved interest meetings nicotine replacement psychosocial relapse risk relating to nervous system response reward processing smoking cessation substance abuse treatment theories tobacco abstinence translational study

项目摘要

DESCRIPTION (provided by applicant): Nicotine dependence is associated with enhanced engagement of brain regions involved in reward processing and habitual responses that contributes to an increased motivational drive to smoke despite known negative consequences. The neural substrates underlying these drives include ventral and dorsal striatum, anterior cingulate cortex, dorsolateral prefrontal cortex, and insula. Current treatments, including both pharmacological and psychosocial interventions, target the incentive value of cigarettes, motivation to smoke, and situations that lead to smoking, but remain only modestly effective at reducing cigarette smoking. A new potential treatment for substance abuse has utilized cognitive retraining of implicit approach motivations towards substance of abuse, and likely works by reducing incentive motivation and desire to consume drugs of abuse. Few attempts have been made to explicitly enhance cortical regions involved behavioral control, another manner by which it may be possible to reduce motivational drives to smoke. Trans-cranial direct current stimulation (TDCS) is one method of brain stimulation that is known to increase cortical excitability, and its application can result in reduced craving, enhanced behavioral control, and enhanced learning, suggesting that TDCS may be useful for augmenting current treatment approaches. We propose to test the degree to which combined brain stimulation and cognitive retraining can augment nicotine replacement therapy in 1) reducing automatic approach biases towards cigarettes, and 2) reducing cigarette use in nicotine dependent individuals. To that end, we will conduct a double-blind investigation of the effects of combining full strength or sham TDCS with active or sham tobacco motivation retraining on automatic motivational biases towards cigarettes and smoking. In addition, all participants will receive a 10-week nicotine replacement regimen as the baseline treatment.

描述（由申请人提供）：尼古丁依赖与参与奖赏处理和习惯性反应的大脑区域的参与增强有关，这有助于增加吸烟的动机，尽管已知有负面后果。这些驱动力背后的神经基质包括腹侧和背侧纹状体、前扣带皮层、背外侧前额叶皮层和岛叶。目前的治疗方法，包括药物和社会心理干预措施，都针对香烟的激励价值、吸烟动机以及导致吸烟的情况，但在减少吸烟方面仍然效果有限。药物滥用的一种新的潜在治疗方法利用了对滥用药物的隐性方法动机的认知再训练，并且可能通过减少消费滥用药物的激励动机和欲望来发挥作用。很少有尝试明确增强涉及行为控制的皮层区域，这是减少吸烟动机的另一种方式。经颅直流电刺激 (TDCS) 是一种已知可以增加皮质兴奋性的脑刺激方法，其应用可以减少渴望、增强行为控制和增强学习能力，这表明 TDCS 可能有助于增强电流治疗接近。我们建议测试大脑刺激和认知再训练相结合可以在多大程度上增强尼古丁替代疗法：1）减少对香烟的自动方法偏见，2）减少尼古丁依赖个体的香烟使用。为此，我们将进行双盲调查，研究将全力或假 TDCS 与主动或假烟草动机再训练相结合对卷烟和吸烟的自动动机偏见的影响。此外，所有参与者都将接受为期 10 周的尼古丁替代方案作为基线治疗。