Resource Core 1: Experimental Core

资源核心 1：实验核心

• 批准号: 8982184
• 负责人: Liz Simon
• 金额: $ 62.31万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8982184
• 关键词: AIDS/HIV problem; Alcohol consumption; Alcohols; Ambulatory Care Facilities; Animals; Award; Basic Science; Behavioral; Biological; Caring; Center for Translational Science Activities; Chronic; Clinical; Clinical Data; Clinical Research; Clinical Sciences; Collaborations; Consent; Data; Data Collection; Disease; Enrollment; Ensure; Environment; Equipment and supply inventories; Ethics; Goals; HIV; Human Resources; Individual; Leadership; Life; Longitudinal Studies; Louisiana; Macaca mulatta; Modeling; Monitor; NCI Center for Cancer Research; Participant; Pathogenesis; Pattern; Persons; Pilot Projects; Play; Postdoctoral Fellow; Preparation; Procedures; Quality Control; Quality of Care; Recruitment Activity; Research; Research Design; Research Personnel; Research Project Grants; Resources; Role; SIV; Sampling; Scientist; Secure; Teacher Professional Development; Training; Training Support; Translational Research; University Hospitals; Veterinarians; Work; abstracting; alcohol research; alcohol use disorder; animal care; behavior measurement; knowledge translation; nonhuman primate; pre-clinical; pre-doctoral; preclinical study; research study; translational study; viral transmission

Abstract LSUHSC CARC Experimental Core The Experimental Core of the LSUHSC Comprehensive Alcohol Research Center (CARC) is comprised of a Pre-clinical Non-Human Primate Research (NHPR) Unit and a Clinical Translational Research (CTR) Unit. The Experimental Core will support all translational preclinical and clinical studies proposed by the Research Components (RC) and Pilot Projects in this application. The Experimental Core will coordinate and execute all experimental procedures for pre-clinical studies using our established chronic binge alcohol (CBA) Simian Immunodeficiency Virus (SIV) non-human primate (NHP) model and proposed clinical studies in persons living with HIV/AIDS (PLWHA). The overall goal of the Experimental Core is to provide high quality care, treatment, monitoring and use of NHP in CBA/SIV studies, and to coordinate and conduct translational studies in order to examine the impact of alcohol use disorders (AUD), including alcohol consumption patterns on comorbid conditions in PLWHA. The Experimental Core will work in close collaboration with the Analytical Core to manage and optimize the transfer of biological, clinical, and behavioral data collected for storage, preparation, and analysis. The Experimental Core will promote cooperation, efficiency, quality control, and translational abilities for CARC investigators. The Specific Aims (SA) of the Core are: 1) To provide leadership, management and coordination for preclinical and clinical translational studies; 2) To coordinate and execute NHPR studies; 3) To recruit, consent, and enroll study participants and conduct clinical cross-sectional and longitudinal studies; 4) To coordinate biospecimen and data collection, from pre-clinical and clinical studies, and their transfer to the Analytical Core; 5) To participate in the training of faculty, pre- and post-doctoral fellows, and staff performing research in the NHP model of CBA/SIV or in PLWHA. The CARC Experimental Core will further support CARC investigators through: a) ensuring regulatory compliance for all pre-clinical and clinical studies conducted by individual RC and Pilot Projects; b) facilitate bidirectional translational opportunities between basic and clinical researchers; c) training of personnel and trainees working on CARC alcohol research projects in the use of NHP and on the basics of clinical research; d) ensuring collection of data for clinical sub-aims proposed by RC1 and RC2; e) providing CARC investigators opportunities to expand the scope of research on the impact of AUD on SIV/HIV disease; and f) facilitating CARC investigator interaction with LSUHSC Division of Animal Care (DAC), the HIV Outpatient (HOP) Clinic, and the University Hospital Clinical Translational Research Center (CTRC). The Experimental Core will synergize with existing LSUHSC resources including the DAC, CTRC and the Louisiana Clinical and Translational Science Award (LA CaTS), and the Louisiana Cancer Research Center. The Experimental Core will leverage the existing excellent basic science environment and expertise of our investigators and transform and expand our research approach to involve clinical research, allowing translation of knowledge gained from our NHP basic science studies.

摘要 LSUHSC CARC 实验核心 LSUHSC 综合酒精研究中心 (CARC) 的实验核心由 临床前非人类灵长类动物研究 (NHPR) 单位和临床转化研究 (CTR) 单元。实验核心将支持该委员会提出的所有转化临床前和临床研究 此应用程序中的研究组件 (RC) 和试点项目。实验核心将协调和 使用我们既定的慢性酗酒 (CBA) 执行临床前研究的所有实验程序 猿猴免疫缺陷病毒（SIV）非人灵长类（NHP）模型和拟议的临床研究 艾滋病毒/艾滋病感染者 (PLWHA)。实验核心的总体目标是提供高质量 CBA/SIV 研究中 NHP 的护理、治疗、监测和使用，并协调和进行转化 研究旨在检查酒精使用障碍 (AUD) 的影响，包括饮酒模式 PLWHA 的共病状况。实验核心将与分析核心密切合作 管理和优化收集用于存储的生物、临床和行为数据传输的核心， 准备、分析。实验核心将促进合作、效率、质量控制和 CARC 研究人员的转化能力。核心的具体目标 (SA) 是： 1) 提供领导力， 临床前和临床转化研究的管理和协调； 2）协调和执行 NHPR 研究； 3) 招募、同意和登记研究参与者并进行临床横断面和 纵向研究； 4) 协调临床前和临床研究的生物样本和数据收集， 以及将它们转移到分析核心； 5）参加教师、博士前、博士后培训 在 CBA/SIV 或 PLWHA 的 NHP 模型中进行研究的研究员和工作人员。 CARC实验 Core 将通过以下方式进一步支持 CARC 研究人员：a) 确保所有临床前和 由各个 RC 和试点项目进行的临床研究； b) 促进双向翻译 基础研究人员和临床研究人员之间的机会； c) 对 CARC 工作人员和受训人员进行培训 NHP 使用和临床研究基础知识的酒精研究项目； d) 确保收集 RC1 和 RC2 提出的临床子目标的数据； e) 为 CARC 调查人员提供扩展的机会 AUD 对 SIV/HIV 疾病影响的研究范围； f) 为 CARC 调查员提供便利 与 LSUHSC 动物护理部 (DAC)、艾滋病毒门诊 (HOP) 诊所和大学的互动 医院临床转化研究中心（CTRC）。实验核心将与现有的协同作用 LSUHSC 资源包括 DAC、CTRC 和路易斯安那临床与转化科学奖 (LA CaTS）和路易斯安那州癌症研究中心。实验核心将利用现有的优秀 我们的研究人员的基础科学环境和专业知识，并转变和扩展我们的研究方法 涉及临床研究，从而能够转化从 NHP 基础科学研究中获得的知识。