1/3 Treatment of Anxiety in Autism Spectrum Disorder

1/3 自闭症谱系障碍焦虑的治疗

• 批准号: 8985687
• 负责人: Jeffrey James Wood
• 金额: $ 22.14万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-12-16 至 2018-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8985687
• 关键词: Acquired Immunodeficiency Syndrome; Address; Adolescent; Adverse effects; Affect; Aftercare; Age; Anxiety; Anxiety Disorders; Autacoids; Autistic Disorder; Behavior Therapy; Behavioral; Binding Sites; Characteristics; Child; Childhood; Cities; Clinical Services; Clinical Trials; Cognitive; Cognitive Therapy; Communities; Comorbidity; Data; Data Analyses; Data Analytics; Diagnosis; Disadvantaged; Distress; Drug Interactions; Effect Modifiers (Epidemiology); Elements; Evidence based treatment; Felis catus; Florida; Frequencies; Friendships; Funding; Goals; Health; Impairment; Institution; Intervention; Leadership; Link; Literature; Loneliness; Maintenance; Measures; Mediating; Mediator of activation protein; Mental Health; Mental disorders; Monitor; Outcome; Parents; Patients; Pharmaceutical Preparations; Poly(ADP-ribose) Polymerases; Population; Procedures; Protocols documentation; Public Health; Publications; Randomized; Randomized Clinical Trials; Randomized Controlled Trials; Recruitment Activity; Recurrence; Relapse; Research; Research Personnel; Resources; Schools; Services; Severities; Site; Social Functioning; Specific qualifier value; Structure; Symptoms; Syndrome; Testing; Training; Treatment Efficacy; Treatment Protocols; Treatment outcome; United States National Institutes of Health; Universities; Wood material; Work; Youth; alcohol use disorder; anxiety treatment; autism spectrum disorder; base; behavior observation; clinically significant; coping; data management; design; experience; flexibility; follow-up; functional outcomes; improved; individual patient; meetings; personalized intervention; programs; psychosocial; quality assurance; response; social; social anxiety; symposium; treatment adherence; treatment effect; treatment of anxiety disorders; treatment responders; treatment response; treatment site; trial comparing

DESCRIPTION (provided by applicant): Autism spectrum disorders (ASD) are common neurodevelopmental syndromes affecting 1% of U.S. children. Comorbid anxiety disorders affect 40 to 50% of children with ASD, causing substantial distress and impairment over and above that caused by ASD alone. High anxiety is associated with increased severity of ASD symptoms and social maladjustment in affected youth. Further, parents of children with ASD consider anxiety-related problems to be among the top two challenges facing their children. [Although standard practice cognitive-behavioral therapy (CBT) has been established as an efficacious and safe treatment for anxiety disorders among typically developing youth, its utility in comorbid cases with ASD remains unknown. To date, no studies have experimentally compared standard practice CBT to a cognitive-behavioral intervention that has been personalized for children with a comorbid presentation of anxiety and ASD.] This gap in the literature is of particular concern because there are no empirically-supported treatment options for youth with ASD and comorbid anxiety, and existing pharmacological interventions may have some disadvantages (e.g., limited efficacy in this population, side effects, and potential for drug x drug interactions). [Accordingly, we are proposing a randomized controlled trial to be conducted at three treatment sites to evaluate the efficacy of personalized CBT for anxiety in ASD (Behavioral Intervention for Anxiety in Children with Autism: BIACA) relative to standard practice CBT for anxiety (Coping Cat program). Over the last five years, the proposed BIACA intervention has been adapted and tailored to the characteristics and needs of high-functioning children with ASD; the Coping Cat program reflects the community standard that has been empirically supported in multiple NIH-funded trials.] In response to the NIH Roadmap Initiative, BIACA employs a modular treatment approach, allowing the intervention to be personalized to each youngster's unique needs. [Thus, the proposed research will: (1) examine the efficacy of BIACA relative to Coping Cat, which represents standard practice treatment, (2) evaluate the maintenance of treatment gains, (3) examine the impact of personalized intervention on functional outcomes such as social responsiveness, loneliness, and friendship quality, (4) test autism severity as a moderator of treatment outcome, and (5) explore other moderators and mediators of treatment outcome.] A total of 180 youth (ages 8-13 years) with ASD and co-occurring anxiety will be randomly assigned to one of the two treatment conditions. The three recruitment sites for this study are UCLA, the University of South Florida (USF), and Temple University. USF will provide data management services. Considering the rising number of children diagnosed with ASD together with the frequency and severity of comorbid anxiety, the proposed work is tailored to the unique needs of youth with ASD and will provide a timely contribution to public health efforts.

描述（由申请人提供）：自闭症谱系障碍 (ASD) 是常见的神经发育综合征，影响 1% 的美国儿童。共病焦虑症影响 40% 至 50% 的自闭症谱系障碍儿童，其造成的痛苦和损害远远超过自闭症谱系障碍单独造成的痛苦和损害。高度焦虑与受影响青少年自闭症谱系障碍症状的严重程度和社会适应不良有关。此外，自闭症儿童的父母认为与焦虑相关的问题是孩子面临的两大挑战之一。 [尽管标准认知行为疗法 (CBT) 已被确立为治疗典型青少年焦虑症的有效且安全的方法，但其在自闭症谱系障碍 (ASD) 共病病例中的效用仍然未知。迄今为止，还没有研究通过实验将标准实践 CBT 与针对患有焦虑和自闭症谱系障碍 (ASD) 共病的儿童进行个性化的认知行为干预进行比较。] 文献中的这一差距特别值得关注，因为没有经验支持的治疗方法患有自闭症谱系障碍 (ASD) 和共病焦虑的青少年的选择，现有的药物干预措施可能有一些缺点（例如，对该人群的疗效有限、副作用以及药物治疗的潜力） x 药物相互作用）。 [因此，我们提议在三个治疗地点进行一项随机对照试验，以评估个性化 CBT 对自闭症儿童焦虑症（自闭症儿童焦虑行为干预：BIACA）相对于标准 CBT 治疗焦虑症（应对猫）的疗效。程序）。在过去五年中，拟议的 BIACA 干预措施已根据患有 ASD 的高功能儿童的特征和需求进行了调整和定制；应对猫计划反映了在多项 NIH 资助的试验中得到实证支持的社区标准。] 为了响应 NIH 路线图倡议，BIACA 采用模块化治疗方法，允许根据每个年轻人的独特需求进行个性化干预。 [因此，拟议的研究将：(1) 检查 BIACA 相对于 Coping Cat 的疗效，后者代表标准实践治疗，(2) 评估治疗效果的维持，(3) 检查个性化干预对功能结果的影响，例如作为社会反应性、孤独感和友谊质量，(4) 测试自闭症严重程度作为治疗结果的调节因素，以及 (5) 探索治疗结果的其他调节因素和调节因素。] 总共 180 名青少年（8-13 岁）年）患有自闭症谱系障碍（ASD）并同时发生焦虑症的患者将被随机分配到两种治疗条件之一。这项研究的三个招聘地点是加州大学洛杉矶分校、南佛罗里达大学 (USF) 和天普大学。 USF 将提供数据管理服务。考虑到被诊断患有自闭症谱系障碍的儿童数量不断增加，以及共病焦虑的频率和严重程度，拟议的工作是根据自闭症谱系障碍青少年的独特需求量身定制的，将为公共卫生工作做出及时的贡献。

项目成果

Reward Sensitivity Predicts the Response to Cognitive Behavioral Therapy for Children with Autism and Anxiety.

奖励敏感性预测自闭症和焦虑儿童对认知行为治疗的反应。

• 发表时间: 2023
• 作者: Hollocks, Matthew J;Wood, Jeffrey J;Storch, Eric A;Cho, An;Kerns, Connor M;Kendall, Philip C
• 通讯作者: Kendall, Philip C

Cognitive Behavioral Treatments for Anxiety in Children With Autism Spectrum Disorder: A Randomized Clinical Trial.

针对自闭症谱系障碍儿童焦虑的认知行为治疗：一项随机临床试验。

• 发表时间: 2020
• 影响因子: 25.8
• 作者: Wood, Jeffrey J;Kendall, Philip C;Wood, Karen S;Kerns, Connor M;Seltzer, Michael;Small, Brent J;Lewin, Adam B;Storch, Eric A
• 通讯作者: Storch, Eric A