Maternal Psychosis and Stress as Risks for Offspring Behavioral Impairment

母亲精神病和压力是后代行为障碍的风险

• 批准号: 9180036
• 负责人: CINDY H LIU
• 金额: $ 16.97万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-04 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9180036
• 关键词: 4 year old; 7 year old; Accounting; Address; Adolescence; Adopted; Affect; Age-Months; Apgar Score; Area; Autonomic nervous system; Behavioral; Behavioral Model; Biological; Biological Models; Birth; Case-Control Studies; Child; Child Rearing; Childhood; Clinical; Clinical Research; Cognitive; Communities; Complex; Data; Data Analyses; Data Collection; Data Set; Development; Discipline of obstetrics; Disease; Emotional; Environment; Environmental Risk Factor; Equilibrium; Event; Exposure to; Face; Family; Family Study; Genetic; Goals; Hair; Healthcare; Heart Rate; Hydrocortisone; Hypoxia; Impairment; Infant; Infant Behavior; Infant Development; Infection; Intervention; Intervention Studies; K-Series Research Career Programs; Knowledge; Lead; Life; Life Stress; Maternal and Child Health; Measures; Mental disorders; Modeling; Mood Disorders; Moods; Mothers; National Institute of Mental Health; Neurologic; New England; Newborn Infant; Outcome; Parents; Patient Self-Report; Perinatal; Perinatal Exposure; Phase; Physiological; Physiology; Plant Roots; Play; Population; Postpartum Period; Poverty; Pre-Eclampsia; Pregnancy; Pregnant Women; Prevention; Preventive Intervention; Principal Investigator; Psychosocial Stress; Psychotic Disorders; Readiness; Research; Research Personnel; Risk; Risk Factors; Role; Running; Salivary; Sampling; Schizophrenia; Schools; Science; Skills Development; Stress; System; Time; Training; Translational Research; Woman; abstracting; adverse outcome; affective psychoses; base; behavior measurement; behavioral impairment; behavioral outcome; career; case control; cohort; comparison group; design; developmental neurobiology; disability; emerging adult; experience; fetal; heart rate variability; high risk; hypothalamic-pituitary-adrenal axis; improved; infancy; intergenerational; longitudinal analysis; maternal anxiety; maternal depression; maternal stress; neurobehavior; neurobehavioral; nutrition; offspring; population based; prenatal; prenatal experience; prenatal exposure; prenatal stress; prevent; prospective; psychobiologic; psychosocial; response; skill acquisition; skills; social; stressor; therapy development; transmission process

Project Summary/Abstract This project is designed to improve the lives of women with psychosis and their children, an ”ignored” population, despite the stress and adversity experienced by these women during the perinatal period, and the documented biological and psychosocial risks on their children for a wide range of behavioral and cognitive problems. What is promising are the ways to potentially identify the early signs for these impairments by studying mothers and offspring as early as pregnancy. This K-award application aims to prepare Dr. Cindy Liu to become an independent clinical researcher and to develop expertise in many of the issues that face women with psychosis and their families; specifically, expertise in the consequences of maternal stress experiences and the ability to ultimately develop interventions that ameliorate stress and its derailing consequences for children. To accomplish this, the proposed research strategy bridges two highly relevant areas within the field: familiar high-risk (HR) research in psychosis and biologically based early stress models from developmental science through complementary two studies. Through Study 1, a secondary data analysis of a large longitudinal birth cohort dataset, early biological and environmental risks and early behavioral impairments from birth to age 7 years will be identified in offspring of parents with psychosis (n=208) and in matched controls (n=132). In Study 2, Dr. Liu will identify behavioral and physiological markers of adverse outcomes in a new sample of children and their mothers with psychosis (n=25), and matched comparison groups, mothers with non-psychotic mood disorders (n=25), and control mothers without psychiatric disorders (n=25) through primary data collection, by assessing behavioral and physiological responses in mothers and children from pregnancy until 4 months postpartum. These two studies provide the opportunity to investigate prenatal stress across different time frames and to utilize developmentally appropriate biological and behavioral measures of stress with this population. Doing so may answer questions about the mechanisms leading to developmental impairments in these high-risk children and will prepare Dr. Liu to develop a R01 proposal that informs how perinatal stress experiences affect socio-emotional development in high-risk children at 4 years of age. In summary, the training plan to be implemented will support Dr. Liu's transition to independence. The two studies will provide a range of unique macro to micro skill development that targets the role of stress on behavioral and physiological reactivity in high-risk children at specific developmental time points. Moreover, the project focus of assessing longitudinal trajectories for risk through a biological and behavioral model of early stress advances the NIMH priority for developmental translational research. It is poised to make a meaningful contribution toward understanding the development of psychiatric conditions and to inform targeted prevention and treatment interventions for families affected by psychosis.

项目概要/摘要 该项目旨在改善患有精神病的妇女及其孩子的生活，这些孩子是“被忽视的”群体 尽管这些妇女在围产期经历了压力和逆境，但 记录了孩子在各种行为和认知方面的生物和心理社会风险 有希望的是通过以下方法来潜在地识别这些损伤的早期迹象。 这项 K 奖申请旨在为 Cindy Liu 博士做好准备。 成为一名独立的临床研究员，并在妇女面临的许多问题上发展专业知识 与精神病及其家人有关；特别是关于母亲压力经历后果的专业知识； 以及最终制定缓解压力及其破坏性后果的干预措施的能力 为了实现这一目标，拟议的研究战略将该领域的两个高度相关的领域联系起来： 熟悉的精神病高风险（HR）研究和发育过程中基于生物学的早期压力模型 通过互补的两项研究进行科学研究。通过研究 1，对大量数据进行二次分析。 纵向出生队列数据集、早期生物和环境风险以及早期行为障碍 从出生到 7 岁的父母患有精神病 (n=208) 的后代以及匹配的 在研究 2 中，刘博士将确定对照组的不良结果的行为和生理标志。 患有精神病的儿童及其母亲的新样本（n = 25）以及匹配的对照组，母亲 患有非精神性情绪障碍（n = 25），并通过控制没有精神障碍的母亲（n = 25） 通过评估母亲和儿童的行为和生理反应来收集主要数据 怀孕至产后 4 个月 这两项研究提供了调查产前压力的机会。 跨越不同的时间框架，并利用适合发育的生物和行为措施 这样做可能会回答有关导致发育的机制的问题。 这些高风险儿童的损伤，并将帮助刘博士制定一项 R01 提案，告知如何 围产期压力经历会影响 4 岁时高危儿童的社会情感发展。 综上所述，即将实施的培训计划将支持刘博士向独立过渡。 研究将提供一系列独特的宏观到微观技能发展，针对压力的作用 高危儿童在特定发育时间点的行为和生理反应。 项目重点是通过早期的生物和行为模型评估风险的纵向轨迹 压力推动了 NIMH 发展转化研究的优先事项，它有望产生有意义的成果。 有助于了解精神疾病的发展并为有针对性的预防提供信息 以及对受精神病影响的家庭的治疗干预。