Intraoperative OCT Guidance of Intraocular Surgery

眼内手术术中OCT指导

• 批准号: 8788030
• 负责人: JOSEPH A IZATT
• 金额: $ 96.96万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8788030
• 关键词: Achievement; Adjuvant; Algorithmic Software; Anatomy; Anterior; Biomedical Engineering; Biomedical Research; Clinic; Clinical Trials; Collaborations; Cornea; Data; Engineering; Evaluation; Eye; Faculty; Feedback; Foundations; Generations; Goals; Health; Image; Imagery; Institutes; Interdisciplinary Study; Laboratories; Leadership; Life; Location; Manufacturer Name; Microscope; Microscopic; Microsurgery; Nursing Faculty; Operating Rooms; Operative Surgical Procedures; Optical Coherence Tomography; Outcome; Patients; Phase; Relative (related person); Research; Retina; Sampling; Speed; Structure; Surgeon; Surgical Instruments; System; Technology; Testing; Time; Tissues; United States National Institutes of Health; Universities; Update; base; clinical research site; data integration; data visualization; design; eye center; functional outcomes; image guided; image processing; improved; instrument; intraoperative imaging; next generation; novel; prototype; research clinical testing; tool; visual feedback

DESCRIPTION (provided by applicant): This Bioengineering Research Partnership proposal brings together a team of experts in ophthalmic imaging and surgery to advance the state of the art in image-guided surgical interventions. We seek to overcome limitations to the surgeon's current stereo microscopic view of ocular structures by bringing optical coherence tomography (OCT) technology, which is already well accepted in ophthalmic practice, into the operating room. In modern microsurgeries of both the anterior segment and retina, the inability to distinguish delicate, microscopic tissue structures of subtle contrast, or to judge the location of surgical instruments relative to adjacent microstructures, limits achievement of surgical endpoints and patient outcomes. The overall five-year goals of the project are to develop, optimize, apply and document a clinically useful, microscope integrated OCT (MIOCT) technology for ophthalmic surgery that overcomes these limitations. We will also facilitate dissemination of this technology through commercial partnerships. We believe this technology will not only improve outcomes in current surgeries, but will also enable novel ophthalmic and other microsurgeries not possible due to current limitations in visualization. Under previous NIH support (R21EY019411), our leadership team has developed a first-generation OCT- enabled microscope that is specialized for vitreoretinal surgery, and is now undergoing clinical trials at Duke University. This first-generation system delivers unprecedented cross-sectional and three-dimensional views of the retina during surgery. It is now ready for clinical evaluation in a wider range of surgeries, including anterior segment surgery. However, the current prototype lacks real-time feedback for the surgeon, and significant advances are needed in the image acquisition, data visualization and integration, and surgical instrument design, to provide a robust and seamless platform for widespread use by ophthalmic surgeons. Our proposed project is based on multidisciplinary collaborations between biomedical engineers, surgeons and image processing experts devoted to translational advances in imaging for improved outcomes in ophthalmic surgery. The proposed Biomedical Research Partnership comprises academic and clinical faculty from Duke University Biomedical Engineering Department (BME) and Duke Eye Center (DEC), faculty at the Cole Eye Institute (CEI) of the Cleveland Clinic Foundation, and substantial support and collaboration from manufacturers of commercial OCT systems, surgical instruments, and surgical microscopes. Page 1 of 1

描述（由申请人提供）：该生物工程研究合作伙伴提案汇集了眼科成像和手术领域的专家团队，以推进图像引导手术干预的最先进水平。我们试图通过将光学相干断层扫描 (OCT) 技术引入手术室，克服目前外科医生眼部结构立体显微镜观察的局限性，该技术已在眼科实践中得到广泛接受。在眼前节和视网膜的现代显微外科手术中，无法区分微妙对比的精致、显微组织结构，或判断视网膜的位置。 手术器械相对于邻近的微观结构限制了手术终点和患者结果的实现。该项目的总体五年目标是开发、优化、应用和记录临床上有用的、用于眼科手术的显微镜集成 OCT (MIOCT) 技术，以克服这些限制。我们还将通过商业伙伴关系促进这项技术的传播。我们相信这项技术不仅会改善当前手术的结果，而且还将实现由于目前可视化的限制而无法实现的新型眼科手术和其他显微手术。 在之前的 NIH 支持下 (R21EY019411)，我们的领导团队开发了第一代 OCT 显微镜，专门用于玻璃体视网膜手术，目前正在杜克大学进行临床试验。该第一代系统在手术过程中提供了前所未有的视网膜横截面和三维视图。现在它已准备好在更广泛的手术中进行临床评估，包括眼前节手术。然而，当前的原型缺乏外科医生的实时反馈，并且在图像采集、数据可视化和集成以及手术器械设计方面需要取得重大进展，以便为眼外科医生广泛使用提供强大且无缝的平台。 我们提出的项目基于生物医学工程师、外科医生和图像处理专家之间的多学科合作，致力于成像领域的转化进展，以改善眼科手术的结果。拟议的生物医学研究合作伙伴关系包括杜克大学生物医学工程系 (BME) 和杜克眼科中心 (DEC) 的学术和临床教职人员、克利夫兰诊所基金会科尔眼科研究所 (CEI) 的教职人员，以及来自制造商的大力支持和合作。商业 OCT 系统、手术器械和手术显微镜。第 1 页，共 1 页