Nuclear Receptors: Full Throttle

核受体：全力以赴

基本信息

批准号：
8985996
负责人：
DAVID L. WOODLAND
金额：
$ 0.6万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-01-01 至 2016-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8985996
关键词：
Academia Address Adverse effects Area Binding Biology Cancer Etiology Cardiovascular Diseases Cessation of life Cholestasis Chromatin Structure Clinical Collaborations Complex Conflict (Psychology)Data Development Diabetes Mellitus Dietary Fats Discipline Disease Drug Targeting Educational workshop Emerging Technologies Endocrine System Diseases Family Fatty acid glycerol esters Fertilization Future Gene Expression Regulation Genetic Genetic Transcription Genome Health Homeostasis Hormones Human Hypertension Immune system Industry Inflammation Joints Knowledge Learning Ligands Longevity Malignant Neoplasms Malignant neoplasm of lung Malignant neoplasm of prostate Membrane Metabolic Diseases Metabolism Methodology Modeling Molecular Nuclear Nuclear Receptors Obesity Outcome Pharmacologic Substance Physiological Physiology Play Process Proteome Quality of life Regulator Genes Reproduction Research Research Personnel Role Science Scientist Senior Scientist Signal Pathway Signal Transduction Speed Tissues Translations Utah Vitamins Woman Work advanced disease career clinical practice combinatorial drug development immune function improved innovative technologies insight interest malignant breast neoplasm meetings men neoplastic new technology next generation non-genomic novel novel strategies posters prevent programs public health relevance receptor receptor function resistance mechanism response sensor steroid hormone receptor symposium therapy resistant transcription factor

项目摘要

DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Nuclear Receptors: Full Throttle, organized by Carol A. Lange, Jennifer K. Richer and Karen E. Knudsen. The meeting will be held in Snowbird, Utah from January 10-15, 2016. Nuclear receptors (NRs) represent a large superfamily of ligand-dependent transcription factor "sensors" for a diverse set of fat-soluble hormones, vitamins and dietary lipids. NRs orchestrate genetic response programs critical for normal homeostasis, and are required for reproduction, development, metabolism and immune function. For this reason, NRs have been investigated for over 30 years as promising targets for drugs to treat a broad spectrum of diseases including cancer, diabetes and other endocrine or metabolic disorders, obesity, cardiovascular disease, hypertension, inflammation and cholestasis. Research on NRs has led to numerous successful therapies for deadly diseases that have improved both longevity and quality of life. However, significant hurdles remain that involve further detailed understanding of the major gene regulatory networks regulated by NRs, how these differ in normal relative to pre-disease and disease states, and the complex problems associated with targeting tissue-specific effects (to reduce side effects) and circumventing mechanisms of resistance. Thus, further insight into the full range of NR functions and interactions with co-regulatory molecules and signaling pathways is necessary for combinatorial approaches involving NRs in health and disease, and development of next-generation therapies. This meeting will bring together a diverse array of our leading scientists, including senior and junior investigators and their trainees, from academic, clinical and pharmaceutical settings, to showcase the latest science, highlight the use of innovative and emerging technologies, explore new directions, and develop collaborative and synergistic efforts in the exciting field of NR biology.

描述（由申请人提供）：请求支持由 Carol A. Lange、Jennifer K. Richer 和 Karen E. Knudsen 组织的题为“核受体：全力以赴”的 Keystone 研讨会。该会议将于 1 月在犹他州斯诺伯德举行。 2016 年 10-15 日。核受体 (NR) 代表配体依赖性转录因子“传感器”的一个大家族，用于多种脂溶性激素，维生素和膳食脂质协调对正常体内平衡至关重要的遗传反应程序，并且是生殖、发育、代谢和免疫功能所必需的，因此，30多年来，NR作为治疗广谱药物的有希望的靶标进行了研究。对癌症、糖尿病和其他内分泌或代谢紊乱、肥胖、心血管疾病、高血压、炎症和胆汁淤积等疾病的研究已经为致命疾病带来了许多成功的治疗方法，这些方法不仅提高了寿命，而且提高了生活质量。障碍仍然存在，需要进一步详细了解 NR 调节的主要基因调控网络，这些网络在正常情况下与病前和疾病状态有何不同，以及与靶向组织特异性效应（以减少副作用）和规避耐药机制相关的复杂问题。对于涉及健康和疾病的 NR 的组合方法以及下一代疗法的开发，深入了解 NR 的功能以及与共调节分子和信号通路的相互作用是必要的。包括高级和初级来自学术、临床和制药领域的研究人员及其学员将展示最新科学，突出创新和新兴技术的使用，探索新方向，并在令人兴奋的 NR 生物学领域开展协作和协同努力。