Understanding Cardiovascular Disease Mechanisms

了解心血管疾病机制

• 批准号: 8969700
• 负责人: Evangelia G Kranias
• 金额: $ 30.52万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-12-01 至 2019-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8969700
• 关键词: Cardiovascular Diseases

 DESCRIPTION (provided by applicant): This is a new application for a pre- and postdoctoral training program, the title and theme of which is "Understanding Cardiovascular Disease Mechanisms". While this is a new T32 application, the cardiovascular training program at the University of Cincinnati and Children's Hospital has a renowned legacy due to 35 years of previous NIH T32 support under Dr. Arnold Schwartz (recently not renewed). The new leadership proposed here, together with a more focused and highly funded faculty wish to carry on this proud tradition of excellence in cardiovascular research and mentorship for another 35 years in Cincinnati. Our collective 19 faculty has placed 297 of their past trainees into academics over their careers, 154 of whom have run, or currently run independent research programs. The overall scientific emphasis of our training program will continue to build from a basic platform of cardiovascular physiology, cell biology, biochemistry and pharmacology, but will also incorporate the latest approaches in the post genomic era, as well as incorporating clinical and translational approaches. The cardiovascular environment at Cincinnati Children's and the University of Cincinnati is considered one of the very best in the country, with 19 NIH funded faculty (some 49 NIH grants amongst them as PI status), 166 collaborative papers published in 10 years, and the very latest technologies and approaches with outstanding core support. The leadership consists of the co-PIs Drs. Evangelia Kranias and Jeffery D. Molkentin, both of whom have a long standing track record of working closely together (15 years), as well as having excellent mentorship credentials. The Executive Committee (2 members), Internal Advisory Committee (4 members) and External Advisory Committee (3 members) are highly engaged cardiovascular researchers who will help ensure the quality of the training program. The current proposal requests funding for 3 pre- and 3 postdoctoral trainees. Predocs are selected by the Internal Advisory Committee from a wide pool arising from departmental graduate programs, while postdoctoral candidates are selected based on being accepted into a mentor's laboratory and then passing the screening process by the Internal Advisory Committee and co-PIs. The mentoring program and evaluation process for the program are highly structured and oversight occurs on many levels. Trainees and mentors are evaluated every 6 months. The proposed educational training curriculum is highly structured and state-of-the-art. Recruitment of minorities has also been successful in the past with our faculty, and it will remain a top priority.

 描述（由申请人提供）：这是一份新的博士前和博士后培训项目申请，其标题和主题是“了解心血管疾病机制”。这是一份新的T32申请，是大学的心血管培训项目。辛辛那提儿童医院拥有著名的遗产，这要归功于 Arnold Schwartz 博士（最近没有续任）领导下的 NIH T32 35 年的支持，以及更专注和高度集中的领导。我们的教师们希望在辛辛那提将这一心血管研究和指导方面的卓越传统继续延续 35 年。我们的 19 名教师已将 297 名过去的学员安置在他们的职业生涯中，其中 154 名已经或目前正在独立资助。我们的培训计划的总体科学重点将继续建立在心血管生理学、细胞生物学、生物化学和药理学的基础平台上，但也将纳入后基因组时代的最新方法，以及结合临床和研究。辛辛那提儿童医院和辛辛那提大学的心血管环境被认为是全国最好的之一，拥有 19 名 NIH 资助的教师（其中约 49 名 NIH 资助，其中 PI 身份），10 年来发表了 166 篇合作论文，其领导层由联合 PI 博士 Evangelia Kranias 和 Jeffery D. Molkentin 组成，他们有着长期密切合作的记录。 （15 年），以及拥有优秀的指导资格的执行委员会（2 名成员）、内部咨询委员会（4 名成员）和外部咨询委员会（3 名成员）都是高度敬业的心血管研究人员，他们将有助于确保培训质量。目前的提案要求为 3 名博士前培训生和 3 名博士后培训生提供资助，这些培训生由内部咨询委员会从院系研究生项目的广泛人才库中选出，而博士后候选人的选择则取决于是否被导师实验室录取并通过。筛选过程由内部咨询委员会和联合 PI 的指导计划和评估流程高度结构化，并且每 6 个月对学员和导师进行一次评估。 -艺术过去我们的教职员工招聘少数族裔也很成功，而且这种情况将会持续下去。 是重中之重。