Understanding Cardiovascular Disease Mechanisms

了解心血管疾病机制

• 批准号: 10176556
• 负责人: Evangelia G Kranias
• 金额: $ 20.33万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-12-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10176556
• 关键词: Cardiovascular Diseases

ABSTRACT This is a first renewal application for a pre- and postdoctoral training program, the title and theme of which is “Understanding Cardiovascular Disease Mechanisms”. The University of Cincinnati and Children’s Hospital has a renowned legacy spanning more than 4 decades of previous NIH T32 support for cardiovascular study, and this current T32 represents the only CV program in Cincinnati. Our collective 18 faculty in this renewal have placed 238 of their past trainees into academics over their careers, 153 of whom have run, or currently run independent research programs. In the past 4 years of this program, our 17 trainees published 43 papers and 5 received independent grant funding during their support period, while 5 graduates have matriculated to jobs in scientific careers. The overall scientific emphasis of our training program will continue to build from a basic platform of cardiovascular physiology, cell biology, biochemistry and pharmacology, but will also incorporate the latest approaches in biomedical research, as well as incorporating clinical and translational approaches. The cardiovascular environment at Cincinnati Children’s and the University of Cincinnati is considered one of the very best in the country. Our 18 TG faculty are all NIH funded (some 47 NIH funding components amongst them as PI status), 165 collaborative papers published together, and they are employing the very latest technologies and approaches with outstanding core support. The leadership consists of the co- PIs Drs. Evangelia Kranias and Jeffery Molkentin, both of whom have a long track record of working together (20 years), as well as having excellent mentorship credentials. The Executive Committee (2 members), Internal Advisory Committee (4 members) and External Advisory Committee (3 members) are highly engaged cardiovascular researchers who will continue to help ensure the quality of the training program. The renewal requests continuation of the funding of 3 pre- and 3 postdoctoral trainee positions. Predocs are selected by the Internal Advisory Committee from a vast and outstanding pool of candidates amongst 7 departmental graduate programs, while postdoctoral candidates are selected based on being accepted into a mentor’s laboratory and then passing the screening process by the Internal Advisory Committee and co-PIs. The mentoring program and evaluation process for the program are highly structured and oversight occurs on many levels. Trainees and mentors are evaluated every 6 months with IDPs processing. The proposed educational training curriculum is highly structured and state-of-the-art. Recruitment of minorities has been successful in the past with our faculty, and it will remain a top priority.

抽象的 这是第一个博士前和博士后培养项目的续签申请，其名称和主题是 “了解心血管疾病机制”。辛辛那提大学和儿童医院。 拥有 4 多年 NIH T32 对心血管研究支持的著名遗产， 目前的 T32 代表了辛辛那提本次更新中唯一的 18 名教员。 在其职业生涯中，已将 238 名过去的学员安排到学术界，其中 153 名已经竞选或目前 在该项目的过去 4 年里，我们的 17 名学员发表了 43 篇论文。 5 名毕业生在资助期间获得独立资助，5 名毕业生已被录取 我们的培训计划的整体科学重点将继续建立在科学职业的岗位上。 心血管生理学、细胞生物学、生物化学和药理学的基础平台，同时也将 结合生物医学研究的最新方法，以及临床和转化 辛辛那提儿童医院和辛辛那提大学的心血管环境是 我们的 18 名 TG 教师均获得 NIH 资助（约 47 名 NIH 资助）。 其中的组成部分为 PI 身份），共发表了 165 篇合作论文，并且他们正在雇用 最新的技术和方法以及出色的核心支持。 PI 博士 Evangelia Kranias 和 Jeffery Molkentin，两人有着长期的合作记录 （20 年），以及具有出色的指导资格的执行委员会（2 名成员）， 内部顾问委员会（4名成员）和外部顾问委员会（3名成员）高度参与 心血管研究人员将继续帮助确保培训计划的质量。 请求继续资助 3 个博士前和 3 个博士后实习生职位，这些职位由博士后遴选。 内部顾问委员会由7名院系毕业生组成的庞大且优秀的候选人组成 计划，而博士后候选人的选择则基于是否被导师实验室录取，以及 然后通过内部咨询委员会和联合 PI 的筛选过程。 该计划的评估过程高度结构化，监督发生在多个层面。 每 6 个月对导师进行一次 IDP 处理评估。 过去，少数族裔的招聘是高度结构化和最先进的。 与我们的教师一起，这仍然是首要任务。