Impact of retroviral infection on non-classical, mycobacteria-specific T cells.

逆转录病毒感染对非经典分枝杆菌特异性 T 细胞的影响。

• 批准号: 9204576
• 负责人: Scott G Hansen
• 金额: $ 22.48万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9204576
• 关键词: Acquired Immunodeficiency Syndrome; Affect; Animal Model; Anti-Bacterial Agents; Antitubercular Agents; Autopsy; Bacteria; Bacterial Infections; Binding; CD8B1 gene; Cause of Death; Cell surface; Cells; Data; Epitopes; Foundations; Frequencies; Genus Mycobacterium; Goals; HIV; HIV drug resistance; Histocompatibility Antigens Class I; Human; Immune response; Immunity; Immunologic Deficiency Syndromes; Immunologic Monitoring; Individual; Infection; Intervention; Ligands; Liver; Location; Lung; Lymphoid; Macaca; Macaca mulatta; Maps; Methodology; Modeling; Monitor; Morbidity - disease rate; Mucosal Immunity; Mucous Membrane; Multi-Drug Resistance; Mycobacterium tuberculosis; Natural Killer Cells; Open Reading Frames; Organ; Peptides; Phenotype; Physiological; Population; Positioning Attribute; Property; Reagent; Recording of previous events; SIV; Science; T cell response; T-Cell Immunodeficiency; T-Lymphocyte; Testing; Therapeutic; Time; Tissues; Tuberculosis; Tuberculosis Vaccines; Vaccinated; Vaccines; Virus Diseases; base; co-infection; design; human disease; immunogenic; mortality; mycobacterial; nonhuman primate; novel; novel vaccines; peripheral blood; prevent; protein aminoacid sequence; response; tool; tuberculosis immunity; vaccination against tuberculosis

Project Summary Over 30 million people are currently infected with HIV, and over 2 million people die from AIDS each year. These numbers are dwarfed only by the number of individuals infected with tuberculosis (TB). Approximately two-thirds of the world's population is currently infected with the bacterium that causes TB, and approximately 10% of those individuals develop active TB. Individuals who are infected with both HIV and TB are up to 31 times more likely to develop tuberculosis than those with TB alone. Thus, there is an inherent need to understand how HIV affects the immune response to TB and whether an intervention can be designed to prevent tuberculosis in co-infected individuals. We have recently identified two unique populations of non- classical CD8+ T cells in rhesus macaques that we believe are critical players in anti-mycobacterial immunity: mucosal associated invariant T cells (MAITs), and MHC-E restricted CD8+ T cells. Thus, the goal of this proposal is to characterize these unique T cells following BCG vaccination and understand how SIV infection impacts their anatomical distribution and function.

项目概要 目前有超过3000万人感染艾滋病毒，每年有超过200万人死于艾滋病。 仅与感染结核病的人数相比，这些数字就显得相形见绌了。大约 目前世界上三分之二的人口感染了引起结核病的细菌，并且大约 其中 10% 患有活动性结核病。同时感染艾滋病毒和结核病的人数高达 31 人 患结核病的可能性比单纯患有结核病的人高出一倍。因此，有一种内在的需要 了解艾滋病毒如何影响结核病的免疫反应，以及是否可以设计干预措施 预防合并感染者的结核病。我们最近发现了两个独特的非非群体 我们认为恒河猴中的经典 CD8+ T 细胞在抗分枝杆菌免疫中发挥着关键作用： 粘膜相关不变 T 细胞 (MAIT) 和 MHC-E 限制性 CD8+ T 细胞。因此，本次活动的目标 建议是在 BCG 疫苗接种后表征这些独特的 T 细胞，并了解 SIV 感染是如何发生的 影响它们的解剖分布和功能。