The University of Iowa Clinical and Translational Science Award

爱荷华大学临床和转化科学奖

• 批准号: 9127390
• 负责人: Patricia Winokur
• 金额: $ 356.07万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-14 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9127390
• 关键词: Academic Medical Centers; Academic support; Academy; Acceleration; Adoption; Affect; American; Area; Arts; Award; Behavioral; Caring; Child; Child Abuse; Clinic; Clinical; Clinical Data; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Communication; Communities; Community Practice; Community of Practice; Computerized Medical Record; Data; Development; Dimensions; Discipline; Disease; Distance Learning; Elderly; Enabling Factors; Epidemiologic Studies; Estrogens; Faculty; Family Physicians; Fostering; Funding; Genetic; Goals; Grant; Health; Health Alliance; Health system; Healthcare; Heart; Hereditary Disease; Hospitals; Human Subject Research; Individual; Institute of Medicine (U.S.); Institutes; Institution; Iowa; Knowledge; Lead; Learning; Link; Locales; Longevity; Longitudinal Studies; Measurable; Medical; Mental disorders; Methods; Mission; Modeling; Multicenter Neonatal Research Network; Patients; Persons; Pharmacists; Phase; Physicians; Population; Positioning Attribute; Postmenopause; Process; Recruitment Activity; Research; Research Design; Research Methodology; Research Personnel; Resources; Risk Factors; Rural; Rural Community; Rural Health; Rural Population; School Nursing; Science; Shapes; Site; Stable Populations; Statistical Methods; System; Technology; Testing; Textiles; Touch sensation; Training; Translating; Translational Research; Translations; Trust; United States National Academy of Sciences; United States National Institutes of Health; Universities; Vision; Woman; Women' s Health; Work; Workforce Development; base; cardiovascular risk factor; catalyst; clinical practice; community organizations; critical access hospital; evidence base; functional decline; health care delivery; improved; informatics infrastructure; innovation; interest; logarithm; medical specialties; meetings; member; multidisciplinary; next generation; novel; novel strategies; novel therapeutics; population health; programs; public health relevance; social; workforce needs; working group

 DESCRIPTION (provided by applicant): The Institute for Clinical and Translational Science (ICTS) at the University of Iowa (UI) was established by the Board of Regents to realize three objectives - first, to lead the development of translational science at the UI; second, to advance translational science as a distinct academic discipline; and third, to disseminate capacities in translational science across the State of Iowa. This mandate enabled us to tackle large problems affecting translational science that required institutional solutions, such as transforming regulatory processes for human subjects research, developing an informatics infrastructure for integrating electronic medical record and other health care data, establishing bi-directional relationships with community organizations, and revitalizing the pipeline of well-trained clinical and translational researchers. The task for this new application is extend our impact and to build a model learning health system (LHS) to integrate research and practice across the lifespan and across the T0 - T4 translational spectrum with the intent of accelerating the translation of discovery to improved population health. Becoming an exemplary next generation CTSA that can produce logarithmic acceleration requires refocusing many current programs and creating new resources to: (1) promote workforce development; (2) systematically engage stakeholders; (3) integrate translational research along several distinct dimensions; and (4) spur innovation. The milestones for this application have a special focus on rural health, community engagement, research- practice integration, clinical research efficiency, innovative statistical methods, and rare genetic diseases. In addition, some of the milestones reflect our interest in working with other CTSA hubs to empirically test different approaches and for developing an evidence base of proven strategies for accelerating translation that can be more broadly disseminated. In this way we can incentivize the development and adoption of new methods and promote innovation in everyday research processes throughout Iowa and beyond our borders. In particular, we will engage investigators and stakeholders across Iowa using approaches that overcome the geographic barriers in a rural state and that build on our established community practice networks of family physicians, clinics, school nurses and pharmacists, with particular examples related to lifespan research and child abuse. To build this LHS we will engage and train undergraduates, pre and postdoctoral trainees, established investigators research staff and clinicians at the UI and in the newly formed UI Health Alliance (an integrated network of 58 hospitals, 175 clinics, critical access hospitals in rural communities regional medical centers, and the UI) which touches 60% of the population in Iowa to drive clinical and translational discovery and to change healthcare practice in a variety of clinical settings.

 描述（由申请人提供）：爱荷华大学（UI）临床与转化科学研究所（ICTS）由董事会成立，旨在实现三个目标：第一，引领爱荷华大学转化科学的发展；第二，推动转化科学成为一门独特的学科；第三，在整个爱荷华州传播转化科学的能力，使我们能够解决影响转化科学的重大问题，这些问题需要制度解决方案，例如改变人类的监管流程。主题开发信息学基础设施，以整合电子病历和其他医疗保健数据，与社区组织建立双向关系，并振兴训练有素的临床和转化研究人员的渠道。这一新应用程序的任务是扩大我们的影响力并扩大我们的影响力。建立一个模型学习健康系统 (LHS)，将整个生命周期和 T0 - T4 转化谱的研究和实践结合起来，旨在加速发现的转化，以改善人口健康，成为可以产生的下一代 CTSA 的典范。对数加速需要重新调整许多当前计划并创造新的资源，以：（1）促进劳动力发展；（2）系统地整合利益相关者；（3）沿着几个不同的维度进行转化研究；（4）刺激创新。 该应用程序的里程碑特别关注农村健康、社区参与、研究实践一体化、临床研究效率、创新统计方法和罕见遗传疾病。此外，一些里程碑反映了我们与其他 CTSA 中心合作的兴趣。实证测试不同的方法，并开发经过验证的加速翻译策略的证据基础，以便更广泛地传播，通过这种方式，我们可以激励新方法的开发和采用，并促进爱荷华州内外日常研究过程的创新。尤其，我们将让爱荷华州各地的调查人员和利益相关者参与进来，采用克服农村州地理障碍的方法，并建立在我们已建立的家庭医生、诊所、学校护士和药剂师社区实践网络的基础上，特别是与寿命研究和虐待儿童有关的例子。为了建立这个 LHS，我们将在 UI 和新成立的 UI Health Alliance（一个由 58 家医院、175 家诊所、农村社区的关键医院组成的综合网络）中吸引和培训本科生、博士前和博士后学员、已建立的研究人员和人群区域医学中心和 UI），该项目涉及爱荷华州 60% 的人口，以推动临床和转化发现并改变各种临床环境中的医疗保健实践。

项目成果

Ambient air pollution and emergency department visits for asthma in Erie County, New York 2007-2012.

2007-2012 年纽约州伊利县环境空气污染和哮喘急诊就诊情况。

• 发表时间: 2018
• 影响因子: 3
• 作者: Castner, Jessica;Guo, Lingfei;Yin, Yong
• 通讯作者: Yin, Yong

Inorganic nitrate supplementation enhances functional capacity and lower-limb microvascular reactivity in patients with peripheral artery disease.

补充无机硝酸盐可增强外周动脉疾病患者的功能能力和下肢微血管反应性。

• 发表时间: 2018-11-01
• 作者: Bock, Joshua M;Treichler, David P;Norton, Samuel L;Ueda, Kenichi;Hughes, William E;Casey, Darren P
• 通讯作者: Casey, Darren P

A Modified MCT-Based Ketogenic Diet Increases Plasma β-Hydroxybutyrate but Has Less Effect on Fatigue and Quality of Life in People with Multiple Sclerosis Compared to a Modified Paleolithic Diet: A Waitlist-Controlled, Randomized Pilot Study.

与改良的旧石器时代饮食相比，改良的基于 MCT 的生酮饮食可增加血浆 β-羟基丁酸，但对多发性硬化症患者的疲劳和生活质量影响较小：一项等候名单控制的随机试点研究。

• 发表时间: 2021
• 影响因子: 3.5
• 作者: Lee, Jennifer E;Titcomb, Tyler J;Bisht, Babita;Rubenstein, Linda M;Louison, Rebecca;Wahls, Terry L
• 通讯作者: Wahls, Terry L

Priming Vaccination With Influenza Virus H5 Hemagglutinin Antigen Significantly Increases the Duration of T cell Responses Induced by a Heterologous H5 Booster Vaccination.

使用流感病毒 H5 血凝素抗原进行初免疫苗接种可显着延长异源 H5 加强疫苗接种诱导的 T 细胞反应的持续时间。

• 发表时间: 2016-10-01
• 作者: Hoft, Daniel F;Lottenbach, Kathleen;Goll, Johannes B;Hill, Heather;Winokur, Patricia L;Patel, Shital M;Brady, Rebecca C;Chen, Wilbur H;Edwards, Kathryn;Creech, C Buddy;Frey, Sharon E;Blevins, Tamara P;Salomon, Rachelle;Belshe, Robert B
• 通讯作者: Belshe, Robert B

Perceived function and physical performance are associated with pain and fatigue in women with fibromyalgia.

纤维肌痛女性的感知功能和身体表现与疼痛和疲劳有关。

• 发表时间: 2016-03-16
• 影响因子: 4.9
• 作者: Dailey, Dana L;Frey Law, Laura A;Vance, Carol G T;Rakel, Barbara A;Merriwether, Ericka N;Darghosian, Leon;Golchha, Meenakshi;Geasland, Katharine M;Spitz, Rebecca;Crofford, Leslie J;Sluka, Kathleen A
• 通讯作者: Sluka, Kathleen A