Alpha Emitter Labeled Anti-T Cell Antibody: Targeting Latent HIV Infected Cells

Alpha 发射体标记的抗 T 细胞抗体：针对潜伏的 HIV 感染细胞

• 批准号: 9301083
• 负责人: BRENDA MARIE SANDMAIER
• 金额: $ 53.95万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9301083
• 关键词: Address; Affect; Affinity Chromatography; Age; Animals; Antibodies; Antigen Targeting; Astatine; Binding; Biodistribution; Blood; Blood specimen; CD3 Antigens; CD4 Antigens; CD4 Positive T Lymphocytes; CD8B1 gene; Calibration; Canis familiaris; Cell Line; Cell model; Cells; Chronic; Clinical; Clinical Trials; Comparative Study; Critiques; Data; Detection; Development; Doctor of Philosophy; Dose; Drug or chemical Tissue Distribution; Effectiveness; Ensure; Exclusion; Freezing; Gel; Generations; Goals; Grant; HIV; Half-Life; High Pressure Liquid Chromatography; Homeostasis; Hour; Human; Hybridomas; Image; In Vitro; Inbred BALB C Mice; Infection; Injection of therapeutic agent; Israel; Kidney; Label; Laboratories; Left; Liver; Lung; Lymphoid Tissue; Macaca; Macaca mulatta; Maintenance; Measures; Mediation; Medical center; Memory; Methods; Modeling; Modification; Molecular Weight; Monoclonal Antibody HuM291; Mus; Natural Killer Cells; Normal tissue morphology; Nude Mice; OKT4A; Phase; Plasma; Preparation; Primates; Process; Product Labeling; Production; Progress Reports; Radioactivity; Radioconjugate; Radioimmunoconjugate; Radiolabeled; Reagent; Regimen; Reporting; Research; Role; SIV; Safety; Scanning; Species Specificity; Specificity; T-Cell Lymphoma; T-Lymphocyte; T-Lymphocyte Subsets; Testing; Time; TimeLine; Tissue Harvesting; Tissues; Toxic effect; Validation; Venous blood sampling; Vial device; Work; Xenograft Model; Xenograft procedure; antigen binding; base; cancer imaging; cell bank; clinical practice; experience; in vivo; killings; latent infection; medical schools; mouse model; nonhuman primate; radiotracer; research study; response; simian human immunodeficiency virus; stability testing; tumor; tumor xenograft; uptake