Quantitative Measurements of Cortical Excitability in Neurodevelopmental Disorder

神经发育障碍中皮质兴奋性的定量测量

• 批准号: 9110300
• 负责人: ANTONIO HARDAN
• 金额: $ 19.75万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-15 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9110300
• 关键词: Achievement; Age; Attention deficit hyperactivity disorder; Auditory; Auditory Evoked Potentials; Auditory Threshold; Behavior; Behavioral; Caregivers; Child; Childhood; Classification; Clinical; Data; Development; Diagnosis; Dimensions; Disease; Electroencephalography; Electrophysiology (science); Epilepsy; Equilibrium; Evaluation; Evoked Potentials; Fragile X Syndrome; Frequencies; Goals; Health; High Prevalence; In complete remission; Individual; Investigation; Judgment; Lead; Link; Machine Learning; Measurement; Measures; Modeling; Monitor; National Institute of Mental Health; Neurobiology; Neurodevelopmental Disorder; Participant; Patients; Pattern; Performance; Phenotype; Population; Prevalence; Psychopathology; Questionnaires; Research; Rest; Sensory; Sensory Process; Specificity; Stimulus; Strategic Planning; Subgroup; System; Techniques; Variant; Visual; Williams Syndrome; auditory stimulus; autism spectrum disorder; base; endophenotype; indexing; infancy; neuromechanism; programs; response; sensory stimulus; sensory system; somatosensory; therapy design; tool; visual stimulus; visual threshold

 DESCRIPTION (provided by applicant): Neurodevelopmental disorders, such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), are characterized by abnormalities in baseline cortical excitability that are believed to be caused by an abnormal, system-wide balance between excitation and inhibition. Mounting evidence has linked baseline cortical excitability to abnormalities in the sensory systems. as manifested by both over- and hypo- reactivity to sensory stimuli and by the high prevalence of epileptiform EEG activity in the majority of neurodevelopmental disorders including ASD and ADHD. Sensory systems rely on a set of well-characterized network of mechanisms whose functioning directly depends on a precise balancing of excitation and inhibition. The aim of this investigation is to use sensory evoked responses as a means to quantitatively assess baseline cortical excitability in two common neurodevelopmental disorders, ASD and ADHD. These measurements will be made via Steady-State Visual and Auditory Evoked Potentials. Patterns sensory responses measured electrophysiologically will be compared to patterns of behavioral hyper/hyposensitivity measured via a well- characterized parental questionnaire and examiner-administered performance evaluations. These measurements will be obtained from 40 children with ASD, 40 children with ADHD and 40 matched controls. The immediate goal of the project is to determine whether specific patterns of sensory evoked potentials are associated with behavioral indices of disturbed sensory processing. The long-term goal of this proposal is to develop sensitive and objective measures of cortical excitability for use in classifying neurodevelopmental disorders. An ability to detect and quantify underlying alterations in cortical excitability in infancy and ealy childhood would be of significant value in the diagnosis, classification and treatment management of common neurodevelopmental disorders. The present proposal is a fundamental step toward the achievement of this purpose and this approach is consistent with the NIMH Strategic Plan for the development of new ways of classifying psychopathology based on dimensions of observable behavior and neurobiological measures.

 描述（由申请人提供）：神经发育障碍，例如自闭症谱系障碍（ASD）和注意力缺陷多动障碍（ADHD），其特征是基线皮质兴奋性异常，据信这是由系统范围内的异常平衡引起的。越来越多的证据表明，基线皮质兴奋性与感觉系统的异常有关，表现为对感觉刺激的过度反应和低反应以及癫痫样脑电图活动的高发生率。大多数神经发育障碍（包括 ASD 和 ADHD）依赖于一组特征明确的机制网络，其功能直接取决于兴奋和抑制的精确平衡。评估两种常见神经发育障碍（自闭症谱系障碍（ASD）和多动症（ADHD））的基线皮质兴奋性。这些测量将通过稳态视觉和听觉诱发电位的感觉反应与电生理学测量的模式进行比较。通过详细描述的家长调查问卷和检查员管理的表现评估来测量行为过度/过敏。这些测量将从 40 名患有 ASD 的儿童、40 名患有 ADHD 的儿童和 40 名匹配的对照中获得。该项目的直接目标是确定是否存在特定的行为。感觉诱发电位的模式与感觉处理紊乱的行为指数相关。该提案的长期目标是开发敏感且客观的皮质兴奋性测量方法，用于对神经发育障碍进行分类。并量化婴儿期和幼儿期皮质兴奋性的潜在变化对于常见神经发育障碍的诊断、分类和治疗管理具有重要价值。本提议是实现这一目的的基本一步，并且该方法与NIMH 战略计划，制定基于可观察行为和神经生物学测量维度的精神病理学分类新方法。

项目成果

A case-control study of visual, auditory and audio-visual sensory interactions in children with autism spectrum disorder.

自闭症谱系障碍儿童视觉、听觉和视听感觉相互作用的病例对照研究。

• 发表时间: 2021-04-01
• 影响因子: 1.8
• 作者: Norcia, Anthony M;Lee, Azalea;Meredith, Wesley J;Kohler, Peter J;Pei, Francesca;Ghassan, Stephanie A;Libove, Robin A;Phillips, Jennifer M;Hardan, Antonio Y
• 通讯作者: Hardan, Antonio Y