Behavioral Intervention to Enhance HIV Test/Treat

加强艾滋病毒检测/治疗的行为干预

基本信息

批准号：
9013464
负责人：
SETH C KALICHMAN
金额：
$ 61.98万
依托单位：
UNIVERSITY OF CONNECTICUT STORRS
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-02-01 至 2018-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9013464
关键词：
18 year old AIDS prevention AIDS/HIV problem Acquired Immunodeficiency Syndrome Address Adherence Alcohol or Other Drugs use Anus Appointment Area Attention Behavior Therapy Behavioral Caring Case Management Cellular Phone Clinic Clinical Services Clinical Trials Cognitive Communicable Diseases Communication Communities Community Services Conflict (Psychology)Consent Contracts Counseling Decision Making Drug usage Epidemic Financial compensation HIV HIV Infections HIV Seropositivity Health Human immunodeficiency virus test Informed Consent Intervention Interview Investigation Life Loneliness Measures Mediating Medical Mental Health Modeling Outcome Participant Patients Persons Pharmaceutical Preparations Prevention Prevention strategy Procedures Quality of life Randomized Randomized Clinical Trials Recruitment Activity Research Resources Risk Risk Behaviors Risk Reduction Rural Safe Sex Services Severities Sexually Transmitted Diseases Social isolation Social support Technology Testing Time Transportation of Patients Vagina Viral Load result Woman alcohol and other drug antiretroviral therapy base behavioral outcome co-infection computerized cost design effective intervention follow-up improved intervention effect mathematical model medication compliance meetings men negative mood pill prevent programs relapse prediction response routine care seropositive service utilization sex risk success theories therapy adherence transmission process treatment adherence

项目摘要

DESCRIPTION (provided by applicant): Prevention strategies that aim to test and treat people for HIV infection are undermined by HIV treatment non-adherence and sexually transmitted co-infections (STI). Scalable interventions are urgently needed to sustain low infectiousness by improving HIV treatment adherence and reducing risks for transmitting HIV. This application proposes to test a theory-based behavioral intervention to simultaneously improve HIV treatment adherence and reduce HIV transmission risk behaviors in people living with HIV/AIDS who use alcohol and other drugs. Grounded in Conflict Theory of Decision Making, the intervention will be delivered in a mixed format, with one office-based counseling session followed by four cell phone delivered counseling sessions. The intervention will be conducted in Atlanta and surrounding impoverished areas. Men (n = 250) and women (n = 250) receiving HIV treatment will be recruited from AIDS services and infectious disease clinics. Following informed consent and baseline assessments, participants will be randomly assigned to either an (a) integrated HIV treatment adherence - risk reduction intervention or (b) a time-matched non-contaminating attention control condition. Participants will be followed for 12-months using office-based computerized interviews, unannounced pill counts, and medical chart abstraction. The study will test the hypothesis that a unified, integrated theory-based HIV treatment and risk reduction intervention will reduce HIV transmission risk behaviors, improve HIV treatment adherence, reduce viral load and prevent new STI. The study will also examine the influence of theoretical constructs and structural barriers on intervention outcomes. Factors that predict relapse to non-adherence and risk behaviors in relation to changes in viral load and STI over the 12-month follow-up period will also be a focal point of the study. The intervention under investigation will be among the first to simultaneously address treatment adherence and risk behavior in an integrated model for substance using HIV positive men and women. If shown effective, the intervention model will be ready for immediate dissemination to community and clinical services for people living with HIV/AIDS.

描述（由申请人提供）：旨在检测和治疗艾滋病毒感染者的预防策略因艾滋病毒治疗不依从和性传播合并感染（STI）而受到破坏。迫切需要可扩展的干预措施，通过提高艾滋病毒治疗依从性和降低传播艾滋病毒的风险来维持低传染性。本申请旨在测试一种基于理论的行为干预措施，以同时提高使用酒精和其他药物的艾滋病毒/艾滋病患者的艾滋病毒治疗依从性并减少艾滋病毒传播风险行为。干预措施以决策冲突理论为基础，将以混合形式进行，先进行一次办公室咨询会议，然后进行四次手机咨询会议。干预行动将在亚特兰大及周边贫困地区进行。接受艾滋病毒治疗的男性（n = 250）和女性（n = 250）将从艾滋病服务机构和传染病诊所招募。在知情同意和基线评估之后，参与者将被随机分配到（a）综合艾滋病毒治疗依从性-风险降低干预或（b）时间匹配的非污染性注意力控制条件。将使用基于办公室的计算机化访谈、未公布的药物计数和医疗图表摘要对参与者进行为期 12 个月的跟踪。该研究将检验以下假设：基于理论的统一、综合的艾滋病毒治疗和风险降低干预措施将减少艾滋病毒传播风险行为、提高艾滋病毒治疗依从性、减少病毒载量并预防新的性传播感染。该研究还将探讨理论构建和结构性障碍对干预结果的影响。在 12 个月的随访期内，预测不依从性复发以及与病毒载量和性传播感染变化相关的危险行为的因素也将是该研究的重点。正在调查的干预措施将是首批在艾滋病毒阳性男性和女性物质使用综合模型中同时解决治疗依从性和危险行为问题的干预措施之一。如果显示有效，干预模式将准备好立即传播到社区和为艾滋病毒/艾滋病患者提供的临床服务。