Long-Term Outcomes in Children with Positional Plagiocephaly/Brachycephaly

位置性斜头畸形/短头畸形儿童的长期结果

基本信息

批准号：
8837050
负责人：
Brent Russell Collett
金额：
$ 45.6万
依托单位：
SEATTLE CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-10 至 2019-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8837050
关键词：
3-Dimensional 8 year old Academic achievement Adverse effects Affect Age Age-Months Appearance Area Attenuated Back to Sleep Benign Characteristics Child Child Development Clinical Cognition Cohort Studies Controlled Study Cosmetics Data Deformity Demographic Factors Development Developmental Delay Disorders Diagnosis Early Intervention Equation Funding Future Goals Head Health Image Infant Intervention Language Longitudinal Studies Measures Mediating Modeling Monitor Motor Motor Skills Movement Muscle Tonus Outcome Parents Positioning Attribute Prevalence Prevention Recording of previous events Relative (related person)Research Risk School-Age Population Schools Severities Shapes Sudden infant death syndrome Surface Testing Time Toddler Translating Treatment outcome United States Variant Weight awake base case control cohort cranium digital early childhood follow-up high risk infant improved infancy neuropsychological orthotics plagiocephaly prevent sleep position supine sleep theories

项目摘要

DESCRIPTION (provided by applicant): The prevalence of positional plagiocephaly/brachycephaly (PPB) increased dramatically following the Back to Sleep campaign, from 5% to approximately 20%-30%. It has been assumed that PPB is a benign "side effect" of supine sleep positioning and that skull deformation would resolve as children mature. However, several studies now challenge these assumptions. In a recently completed longitudinal study, we found that children with PPB were at elevated risk for developmental delays relative to unaffected controls from infancy through age 36 months. Although it is unclear whether PPB causes developmental delays, we hypothesize that PPB is a "marker" that could be used to identify infants in need of developmental assessment and intervention. Specifically, we anticipate that early and potentially subtle neuromotor deficits make infants vulnerable to developing PPB and predict deficits in other areas of development. This study will be the first long-term follow-up of children with and without PPB. We will re-assess children who participated in our earlier cohort study with PPB (n=215) and unaffected controls (n=163) at age 8 years. The study will explore two primary hypotheses: (1) Children with PPB will score lower than unaffected controls on neuropsychological and academic achievement measures, and (2) These differences are mediated by infant motor skills. We will also examine the demographic and clinical variables that predict development in children with PPB. Finally, we will examine whether differences in head shape remain measureable and observable for children with PPB versus unaffected controls.

描述（由申请人提供）：“重新入睡”运动后，位置性斜头畸形/短头畸形 (PPB) 的患病率急剧增加，从 5% 增加到大约 20%-30%。人们认为，PPB 是仰卧睡眠姿势的良性“副作用”，头骨变形会随着儿童的成熟而消失。然而，现在有几项研究对这些假设提出了挑战。在最近完成的一项纵向研究中，我们发现，从婴儿期到 36 个月，患有 PPB 的儿童相对于未受影响的对照儿童，发育迟缓的风险更高。尽管尚不清楚 PPB 是否会导致发育迟缓，但我们假设 PPB 是一个“标记”，可用于识别需要发育评估和干预的婴儿。具体来说，我们预计早期和潜在的微妙神经运动缺陷使婴儿容易出现 PPB，并预测其他发育领域的缺陷。这项研究将是对患有和不患有 PPB 的儿童的首次长期随访。我们将在 8 岁时重新评估参加我们早期 PPB 队列研究的儿童 (n=215) 和未受影响的对照组 (n=163)。该研究将探讨两个主要假设：（1）患有 PPB 的儿童在神经心理学和学业成绩测量方面的得分低于未受影响的对照组，以及（2）这些差异是由婴儿运动技能介导的。我们还将检查预测 PPB 儿童发育的人口统计和临床变量。最后，我们将检查 PPB 儿童与未受影响的对照组儿童的头部形状差异是否仍然可测量和观察。