Biopolymers & Proteomics

生物聚合物

• 批准号: 9149768
• 负责人: MICHAEL B YAFFE
• 金额: $ 28.64万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-09 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9149768
• 关键词: Biocompatible Materials; Biopolymers; Budgets; Cancer Center; Cancer Center Support Grant; Core Grant; Custom; DNA; Funding; Genomics; High Pressure Liquid Chromatography; Institutes; Mass Spectrum Analysis; Mission; Molecular Profiling; Peptide Synthesis; Peptides; Post Translational Modification Analysis; Proteins; Proteomics; Recruitment Activity; Research Personnel; Research Support; Resource Sharing; Services; Technical Expertise; Technology; Training; design; instrumentation; member; programs; protein expression; small molecule; success

The Biopolymers & Proteomics Core is a Shared Resource that provides Koch Institute Members with a diverse range of essential services that enable the synthesis and analysis of biological materials and require sophisticated technical expertise and state-of-the-art instrumentation. In the current period, the mission of this Core was modified as part of a larger reorganization plan. First, all DNA-related activities were outsourced or moved to the Koch Institute Genomics Core, thereby allowing the Biopolymers & Proteomics Core to specialize in protein, proteomic and mass spectrometry services. Second, these capabilities were expanded and enhanced by: moving into a larger, custom-designed space; the acquisition of extensive new instrumentation; and the recruitment of an expert Mass Spectrometry Consultant who provides customized technical support and/or training for high-end proteomics projects. Importantly, the Core is used by more than 80% of the Center Members, including investigators from all four programs. Thus, this Shared Resource is essential to the success of the Koch Institute mission. In the upcoming period, this Core will continue to offer a wide range of state-of-the-art technologies to support the research programs of Center Members. Notably, the requested CCSG budget for Year 44 is only two thirds of the requested and recommended budget in Year 39.

生物聚合物和蛋白质组学核心是一个共享资源，为科赫研究所成员提供 各种基本服务，使生物材料的合成和分析成为可能，并需要 先进的技术专长和最先进的仪器。当前时期，本会的使命 作为更大的重组计划的一部分，对核心进行了修改。首先，所有与 DNA 相关的活动都是外包或 转移到科赫研究所基因组学核心，从而使生物聚合物和蛋白质组学核心专业化 蛋白质、蛋白质组学和质谱服务。其次，这些能力得到了扩展 增强方式：搬进更大的、定制设计的空间；购置大量新仪器； 并聘请专业质谱顾问提供定制技术支持 和/或高端蛋白质组学项目的培训。重要的是，核心被超过 80% 的中心使用 成员，包括来自所有四个项目的研究人员。因此，这种共享资源对于 科赫研究所使命的成功。在接下来的一段时间内，该核心将继续提供广泛的 最先进的技术来支持中心成员的研究计划。值得注意的是，所要求的 CCSG 44 年的预算仅为 39 年请求和建议预算的三分之二。