Novel Analyses of Abdominal Computed Tomography Data in CARDIA

CARDIA 腹部计算机断层扫描数据的新分析

• 批准号: 8753002
• 负责人: Andrew Owen Odegaard
• 金额: $ 10.92万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8753002
• 关键词: Abdomen; Address; Adipose tissue; Adult; African American; Age-Years; Animals; Area; Behavior; Body Composition; Body fat; Cardiovascular Diseases; Caucasians; Chronic Disease; Clinical; Clinical Research; Cohort Studies; Communities; Coronary Artery Risk Development in Young Adults Study; Coronary artery; Data; Data Set; Demographic Factors; Development; Diet; Dietary Assessment; Dietary Practices; Dyslipidemias; Energy Intake; Enrollment; Epidemiologic Studies; Epidemiology; Evolution; Fatty Liver; Fatty acid glycerol esters; Foundations; Functional disorder; Funding; Future; Goals; Habits; Health; Hepatic; Human; Hypertension; Image; Insulin Resistance; Intervention; Intervention Studies; Intra-abdominal; Intramuscular; Knowledge; Life Style; Liver; Longitudinal Studies; Manuscripts; Measures; Metabolic; Modeling; National Heart, Lung, and Blood Institute; Nature; Non-Insulin-Dependent Diabetes Mellitus; Organ; Participant; Physical activity; Play; Primary Prevention; Prospective Studies; Psychosocial Factor; Public Health; Publishing; Research; Risk; Risk Marker; Role; Sample Size; Sampling; Scanning; Science; Secondary Prevention; Series; Solid; Television; Time; Translational Research; United States National Institutes of Health; Visceral; Woman; X-Ray Computed Tomography; abdominal fat; attenuation; base; cardiovascular disorder risk; clinical practice; diabetes risk; disorder prevention; improved; insight; lifestyle factors; men; metropolitan; novel; population based; research study; sedentary; sedentary lifestyle; subcutaneous; young adult

 DESCRIPTION (provided by applicant): Accumulating clinical research in animals and humans suggests that high amounts of abdominal fat, particularly within and around the organs inside the abdomen (visceral fat and liver fat), plays a crucial role in risk for diabetes and cardiovascular diseases. However, there have been no large epidemiologic studies examining the role of lifestyle on these abdominal fat stores. Until now, few, if any, epidemiologic cohort studies have included detailed measures of intra-abdominal fat depots from a large sample of community- based participants. The study proposed in this application uses an existing NHLBI dataset to fill these evidence gaps in a series of rigorous analyses. The NHLBI Coronary Artery Risk Development in Young Adults (CARDIA) Study includes detailed assessments of dietary and sedentary behaviors, as well as four abdominal fat depots (subcutaneous, visceral, intramuscular, and hepatic) assessed by computed tomography imaging in 3,170 African American and Caucasian adults that have been followed for 25 years in four U.S. metropolitan regions. The data set also provides a rich array of demographic and psychosocial factors that can be assessed as potential confounding factors. We propose to address the following three specific aims through analyses of CARDIA data in adult African American and Caucasian men and women: 1) Describe the associations between sedentary lifestyle habits and intra-abdominal fat depots. 2) Describe the associations between dietary patterns and hepatic fat. 3) Develop a prediction model for visceral fat volume based upon a combination of common clinical measures for use in research and translation to clinical practice. These analyses will lay the foundation for several areas of future research that we will propose to NIH in future applications, including prospective studies and community-based intervention studies. Such translational research geared towards changing lifestyle with the goal of improving body composition will be crucial towards scientific and public health progress in primary and secondary prevention of chronic diseases.

 描述（由申请人提供）：对动物和人类的临床研究表明，大量的腹部脂肪，特别是腹部器官内部和周围的脂肪（内脏脂肪和肝脏脂肪），在糖尿病和心血管疾病的风险中起着至关重要的作用然而，到目前为止，还没有大型流行病学研究来检验生活方式对这些腹部脂肪储存的作用，很少有流行病学队列研究包括对大样本的腹部脂肪库进行详细测量。本申请中提出的研究使用现有的 NHLBI 数据集来填补一系列严格分析中的证据空白，该研究包括对饮食和久坐行为的详细评估。以及四个腹部脂肪库（皮下、内脏、肌内和肝脏），通过计算机断层扫描成像对 3,170 名非裔美国人和白种人成年人进行了评估，并对这些脂肪库进行了 25 年的跟踪研究。该数据集还提供了丰富的人口和心理社会因素，可以将其评估为潜在的混杂因素，我们建议通过分析成年非裔美国人和白人男性和女性的 CARDIA 数据来解决以下三个具体目标。 ： 1) 描述久坐的生活方式与腹内脂肪库之间的关系 2) 描述饮食模式与肝脏脂肪之间的关系 3) 建立内脏脂肪量的预测模型。这些分析将基于用于研究和转化为临床实践的常见临床措施的组合。 我们将在未来的应用中向 NIH 提出的未来研究的基础，包括前瞻性研究和基于社区的干预研究，这种旨在改变生活方式、以科学改善身体成分为目标的转化研究对于公共健康至关重要。慢性病一级和二级预防取得进展。