Motivated Memory as Therapeutic Target

动机记忆作为治疗目标

基本信息

批准号：
8179688
负责人：
Rachel Alison Adcock
金额：
$ 48.15万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-06-13 至 2016-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8179688
关键词：
Access to Information Affect Behavior Behavioral Biological Brain Chronic Clinical Cognitive Cognitive Therapy Cues Development Dopamine Episodic memory Equilibrium Etiology Event Feedback Foundations Frequencies Functional Magnetic Resonance Imaging Future Goals Hippocampus (Brain)Imagery Intervention Learning Life Long-Term Effects Measures Medial Mediating Memory Methods Midbrain structure Neurotransmitters Participant Patients Protocols documentation Proxy Psychiatry Psychopharmacology Psychotherapy Readiness Regulation Rewards Role Series Signal Transduction Stimulus Symptoms System Techniques Temporal Lobe Testing Therapeutic Time Validation Work abstracting base design dopamine system experience follow-up insight memory encoding mesolimbic system non-drug psychologic relating to nervous system research study response success therapeutic target

项目摘要

DESCRIPTION (provided by applicant): Declarative or episodic memory systems based in the hippocampus and medial temporal lobes are specialized for rapid reorientation to new contexts, supporting appropriately rapid shifts in behavior. Surprisingly, the potential for leveraging these mechanisms in cognitive therapy remains untapped. We have demonstrated that increased fMRI activation of declarative memory systems together with dopaminergic midbrain during reward anticipation correlates with memory encoding for upcoming experience. Our findings suggest a method and mechanism for using "behavioral neurostimulation" of dopaminergic systems to prime the hippocampus for learning. This approach contrasts with conventional paradigms in psychopharmacology where the goal is chronic equilibrium of neuromodulatory systems. Here, the adjustment is explicitly targeted to the period of learning. We propose three series of experiments designed to 1) to test the existence of a causal relationship between mesolimbic activation per se and memory encoding success using real-time fMRI; 2) to demonstrate the suitability of this phenomenon to clinical interventions; and 3) determine long-term effects on behavior from the impact of a single salient episode in a therapeutic session. We expect these studies to provide a foundation for using cognitive and behavioral regulation of dopamine systems to prepare the brain for adaptive learning. PUBLIC HEALTH RELEVANCE: We propose to enhance learning during cognitive therapy by increasing the release of dopamine, a neurotransmitter known to enhance learning and new memory formation, during the specific time period of a cognitive therapy session. We plan to stimulate dopamine systems behaviorally, prior to therapy. We expect these studies to guide the development of non-drug, individually tailored treatments to enhance learning-based therapies in psychiatry.

描述（由申请人提供）：基于海马体和内侧颞叶的陈述性或情景记忆系统专门用于快速重新定位到新环境，支持行为的适当快速转变。令人惊讶的是，在认知治疗中利用这些机制的潜力尚未开发。我们已经证明，在奖励预期期间，陈述性记忆系统和多巴胺能中脑的功能磁共振成像激活增加与即将到来的经历的记忆编码相关。我们的研究结果提出了一种使用多巴胺能系统的“行为神经刺激”来为海马体的学习做好准备的方法和机制。这种方法与精神药理学的传统范例形成鲜明对比，传统范例的目标是神经调节系统的长期平衡。这里，调整是明确针对学习时期的。我们提出了三个系列的实验，旨在：1）使用实时功能磁共振成像测试中脑边缘激活本身与记忆编码成功之间是否存在因果关系； 2）证明这种现象对临床干预的适用性； 3) 根据治疗过程中单个显着事件的影响确定对行为的长期影响。我们希望这些研究能够为利用多巴胺系统的认知和行为调节为大脑的适应性学习做好准备奠定基础。公共健康相关性：我们建议在认知治疗的特定时间段内，通过增加多巴胺的释放来增强认知治疗期间的学习，多巴胺是一种已知可增强学习和新记忆形成的神经递质。我们计划在治疗前从行为上刺激多巴胺系统。我们期望这些研究能够指导非药物、个体化治疗的开发，以增强精神病学中基于学习的疗法。