Integrin-dependent mechanism of T cell-mediated pulmonary fibrosis

T细胞介导的肺纤维化的整合素依赖性机制

• 批准号: 7783794
• 负责人: Irina G. Luzina
• 金额: --
• 依托单位: BALTIMORE VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2012-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7783794
• 关键词: Address; Adverse effects; Allergic inflammation; Animal Model; Animals; Antibodies; Area; Arteriosclerosis; Asthma; Autoimmune Diseases; Autoimmunity; Binding; Bleomycin; Bronchiolitis Obliterans; CCL18 gene; Cause of Death; Cell Communication; Cell Culture Techniques; Cell surface; Cells; Cessation of life; Characteristics; Chronic; Chronic Disease; Cicatrix; Coculture Techniques; Collagen; Connective Tissue; Cross-Sectional Studies; Data; Deposition; Development; Diffuse; Disease; Elderly; Environmental Exposure; Equilibrium; Extracellular Matrix; Extrinsic allergic alveolitis; Fibroblasts; Fibrosis; Future; Goals; Hamman-Rich syndrome; Health; Home environment; Homing; Human; Immune; In Vitro; Infiltration; Inflammation; Inflammatory; Injury; Integrin alphaVbeta3; Integrins; Interferon Type II; Interferons; Interstitial Lung Diseases; Kidney; Knowledge; Liver; Lung; Lung diseases; Lymphocyte; Mediating; Membrane; Military Personnel; Mining; Mission; Modeling; Nature; Organ; Pathologic; Pathologic Processes; Patient Care; Patients; Phenotype; Play; Pneumonia; Population; Process; Production; Pulmonary Fibrosis; Pulmonology; Radiation; Regulation; Research; Rheumatoid Arthritis; Role; Sarcoidosis; Scleroderma; Small Interfering RNA; Syndrome; Systemic disease; T-Lymphocyte; TNF gene; Tissues; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Veterans; Wound Healing; airway remodeling; attenuation; base; chemotherapy; cytokine; healthy volunteer; human EBAF protein; human TNF protein; human subject; in vivo Model; integrin alphaVbeta5; male; neutralizing antibody; novel; overexpression; public health relevance; pulmonary function; research study; wound