Role of Meprin A in Acute Kidney Injury

Meprin A 在急性肾损伤中的作用

• 批准号: 7903314
• 负责人: Gur Prasad Kaushal
• 金额: --
• 依托单位: CENTRAL ARKANSAS VETERANS HLTHCARE SYS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-10-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7903314
• 关键词: Acute; Acute Kidney Failure; Acute Renal Failure with Renal Papillary Necrosis; Address; Admission activity; Affect; Animals; Apical; Binding; Biological Assay; Biological Markers; Blood Circulation; Blood Urea Nitrogen; C3H/He Mouse; CCL2 gene; CD14 gene; Cell membrane; Cells; Cisplatin; Cleaved cell; Collagen Type IV; Creatinine; Cytoplasm; Dialysis procedure; Disease; Disintegrins; Doctor of Philosophy; Early Diagnosis; Enzyme-Linked Immunosorbent Assay; Enzymes; Epithelial Cells; Excretory function; Experimental Models; Extracellular Matrix; Extracellular Matrix Degradation; Extracellular Matrix Proteins; Family; Fibronectins; Generations; Goals; Gur; Hemodialysis; Immunofluorescence Immunologic; In Vitro; Infiltration; Inflammation; Inflammatory; Injury; Interleukin-1; Interleukin-1 beta; Ischemia; Kidney; Kidney Diseases; Kidney Failure; Knockout Mice; Laminin; Leukocyte Trafficking; Leukocytes; Marrow; Matrix Metalloproteinases; Mediating; Membrane; Membrane Proteins; Meprin; Metalloproteases; Molecular; Mouse Strains; Mus; Na(+)-K(+)-Exchanging ATPase; Nephrotoxic; Nidogen; Patients; Peptide Hydrolases; Peripheral; Postoperative Period; Process; Production; Proximal Kidney Tubules; Publishing; Rattus; Recombinants; Reperfusion Therapy; Resistance; Risk; Risk Factors; Role; Serum; Site; Staining method; Stains; T-Lymphocyte; Testing; Therapeutic Intervention; Time; Tissues; Tubular formation; Urine; Veterans; Western Blotting; base; basolateral membrane; brush border membrane; chemokine; clinically relevant; cytokine; in vivo; in vivo Model; inhibitor/antagonist; insight; kidney cortex; member; meprin A; monocyte; mortality; mouse model; nephrotoxicity; new therapeutic target; overexpression; patient population; prevent; protective effect; public health relevance; response; secretase; urinary