Measuring Cognitive Fatigability in Older Adults

测量老年人的认知疲劳度

基本信息

批准号：
8926342
负责人：
MINGZHOU DING
金额：
$ 17.66万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-15 至 2017-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8926342
关键词：
Address Age Aging Attention Brain Cardiovascular system Cerebrum Clinical Trials Cognition Cognitive Cognitive aging Communities Complex Data Elderly Electroencephalography Employee Strikes Event-Related Potentials Exertion Fatigue Foundations Funding Future Goals Health Hour Image Intervention Knowledge Linear Regressions Link Longitudinal Studies Measures Metabolic Modeling Monitor Muscle NIH Program Announcements Neuraxis Neurocognitive Neurons Outcome Participant Pattern Perception Performance Physiological Play Population Procedures Process Prospective Studies Quality of life Research Resources Role Scalp structure Task Performances Techniques Testing Therapeutic Intervention actigraphy age related base clinically significant cognitive ability cognitive function cognitive performance cognitive reserve cognitive task disability effective intervention exhaustion improved innovation insight mortality neurophysiology novel programs therapeutic target tool

项目摘要

DESCRIPTION (provided by applicant): Fatigue is associated with increased mortality in older adults and is the leading cause of activity restrictions in this population. Unfortunately, our understanding of the causes of fatigue in older adults is quite limited and we have no proven treatments. While it is known that aging has profound effects on the central nervous system (CNS) and cognitive function there have been no studies to date attempting to understand how CNS and cognitive factors contribute to fatigue complaints and activity restrictions in older adults. This is a striking gap as CNS and cognitive factors may play a central role in many processes suspected to drive fatigue in older adults and would thus be a potent target for therapeutic interventions. Fatigue is a complex construct which includes subjective perceptions (perceived fatigue) and objective changes in performance (fatigability). The research objectives of this proposal are to: 1) Determine the association between an objective measure of cognitive performance fatigability and activity levels in older adults; and 2) Identify potential neuronal mechanisms of this fatigability. The long-term goal is to determine whether interventions directed at cognition and/or CNS targets restore activity levels in older adults afflicted by fatige. The central hypothesis is that cognitive performance fatigability in older adults contributes to activity restrictions and is due to aging related neurocognitive changes. This hypothesis has been formulated on the basis of our preliminary data showing: 1) Significant correlations between cognitive fatigability and both age and fatigue complaints in older adults; and 2) Associations between physiologic markers of cognitive reserve and cognitive fatigability. The rationale for the proposed research is that better objective measures of cognitive and CNS factors are needed to advance our understanding of fatigability in older adults and to identify targets for therapeutic interventions. The hypothesis will be tested through two Specific Aims: 1) Determine the correlation between cognitive performance fatigability and activity levels in older adults; and 2) Determine the relationship between cognitive fatigability and neurophysiological markers of cognitive reserve using electroencephalography (EEG). The approach is innovative because it represents the first study to examine objective cognitive fatigability as a cause of restricted activity in older adults and is the first study to determine whether physiologic measures of cerebral reserve impact cognitive fatigability. The proposed research is significant because it is expected to advance out understanding of the mechanisms of fatigability in older adults and to contribute new tools, mechanistic insights and therapeutic targets essential for advancing this field. The knowledge and techniques developed in this R21 proposal will serve as a foundation for future R01 proposals to investigate the potential for cognitive interventions t improve activity restrictions in older adults and mechanistic studies to better understand the relationship and interaction of potential causes of restricted activity in older adults including cognitive, CNS, muscular, cardiovascular and metabolic factors.

描述（由申请人提供）：疲劳与老年人死亡率增加有关，是限制该人群活动的主要原因。不幸的是，我们对老年人疲劳原因的了解相当有限，并且没有行之有效的治疗方法。虽然众所周知，衰老对中枢神经系统 (CNS) 和认知功能有深远影响，但迄今为止还没有研究试图了解中枢神经系统和认知因素如何导致老年人的疲劳症状和活动限制。这是一个显着的差距，因为中枢神经系统和认知因素可能在许多疑似导致老年人疲劳的过程中发挥核心作用，因此将成为治疗干预的有效目标。疲劳是一个复杂的概念，包括主观感知（感知疲劳）和客观表现变化（易疲劳性）。该提案的研究目标是： 1）确定老年人认知表现疲劳性的客观测量与活动水平之间的关联； 2）确定这种疲劳的潜在神经机制。长期目标是确定针对认知和/或中枢神经系统目标的干预措施是否可以恢复患有疲劳的老年人的活动水平。中心假设是，老年人的认知表现疲劳性导致活动限制，并且是由于与衰老相关的神经认知变化所致。这一假设是根据我们的初步数据制定的，这些数据显示：1）老年人的认知疲劳性与年龄和疲劳主诉之间存在显着相关性； 2）认知储备的生理标志物与认知疲劳性之间的关联。拟议研究的基本原理是，需要对认知和中枢神经系统因素进行更好的客观测量，以增进我们对老年人疲劳性的理解并确定治疗干预的目标。该假设将通过两个具体目标进行检验：1）确定老年人认知表现疲劳性与活动水平之间的相关性； 2) 使用脑电图 (EEG) 确定认知疲劳性与认知储备的神经生理学标志物之间的关系。该方法具有创新性，因为它代表了第一项将客观认知疲劳性作为老年人活动受限原因的研究，也是第一项确定大脑储备的生理测量是否影响认知疲劳性的研究。拟议的研究意义重大，因为它有望促进对老年人疲劳机制的理解，并为推进这一领域提供必要的新工具、机制见解和治疗目标。 R21 提案中开发的知识和技术将作为未来 R01 提案的基础，以调查认知干预改善老年人活动限制的潜力，并进行机制研究，以更好地了解老年人活动受限的潜在原因之间的关系和相互作用。成人包括认知、中枢神经系统、肌肉、心血管和代谢因素。