Motion Compensated Brain PET Imaging for Neuroscience Research

用于神经科学研究的运动补偿脑 PET 成像

基本信息

批准号：
9049061
负责人：
David M Beylin
金额：
$ 91.2万
依托单位：
BRAIN BIO
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-15 至 2017-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9049061
关键词：
Acceleration Accounting Adoption Adverse effects Agitation Alcohol dependence Algorithms Alzheimer&apos s Disease Biochemistry Brain Brain imaging Calibration Certification Clinic Clinical Clinical Data Clinical Research Computer Vision Systems Delirium Devices Disease Distress Drug Addiction Drug abuse Electromagnetics Equipment Etiology Evaluable Disease Face Failure Financial compensation Freedom Functional disorder Funding Glioblastoma Guidelines Head Head Movements Hospitals Image Imaging technology Immune Impaired cognition Institutional Review Boards Knowledge Laboratory Research Lighting Magnetic Resonance Imaging Malignant neoplasm of brain Maryland Mental disorders Modeling Morphologic artifacts Motion Motor Neuron Disease Movement Disorders Neurologic Neurosciences Research Parkinson Disease Participant Patients Pharmaceutical Preparations Phase Physical Restraint Positioning Attribute Positron-Emission Tomography Postoperative Period Procedures Qualifying Quality Control Radiology Specialty Radiopharmaceuticals Reader Research Resolution Safety Sales Scanning Schizophrenia Sedation procedure Small Business Innovation Research Grant Software Design Supervision Syndrome System Testing Universities Vendor base brain metabolism brain research commercialization cost design experience improved medical schools nervous system disorder novel programs prototype public health relevance reconstruction restraint sedative uptake

项目摘要

DESCRIPTION (provided by applicant): Advanced imaging technologies such as Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MR) have led to remarkable improvement in our knowledge of brain metabolism, function, and biochemistry. And yet, our understanding of most neurological disorders is at best rudimentary. Etiology of such common diseases as drug and alcohol addiction, schizophrenia, Alzheimer's dementia and Parkinson's remains elusive. Malignant brain tumors such as glioblastoma continue being fatal. Changes happening in the brain in such common syndromes as hospital-acquired delirium, and post-operative cognitive decline, are not understood. Most studies involving advanced brain imaging remain small due to logistical challenges, cost constraints, and difficulty of scanning neurological patients in standard radiology equipment. Acceleration of brain research is required to elucidate the pathophysiology of neurological and psychiatric conditions. Brain Biosciences was established to make neurological imaging comfortable, inexpensive, and widely available both in the clinic and in the research laboratory. One of the common problems encountered in imaging research is unintentional patient motion. Head movement during Positron Emission Tomography (PET) degrades PET image quality, leads to image artifacts, and introduces quantitative errors. Motion is particularly common in confused patients with neurological diseases, drug addiction, and movement disorders. This problem becomes especially relevant as research involving lengthy dynamic scans, and high-resolution brain imaging becomes common. While sedation is often used to minimize the patient motion, sedative drugs change brain biochemistry, interfere with radiopharmaceutical uptake, and may cause side effects. Physical restraints are often distressing, and may increase patient agitation. In this direct Phase II SBIR proposal we seek to develop, clinically validate, and receive FDA clearance for FREEMotion(tm), a video-based head tracking system, enabling motion- compensated brain Positron Emission Tomography (PET) imaging of neurological patients without sedation or physical head restraint.

描述（由申请人提供）：正电子发射断层扫描（PET）和磁共振成像（MR）等先进成像技术极大地提高了我们对大脑代谢、功能和生物化学的了解，而且我们对大多数神经学的理解也有了显着提高。药物和酒精成瘾、精神分裂症、阿尔茨海默氏痴呆和帕金森氏症等常见疾病的病因学仍然难以捉摸。胶质母细胞瘤仍然是致命的，但由于后勤方面的挑战、成本限制和困难，大多数涉及高级脑成像的研究仍然很小。需要使用标准放射学设备对患者进行神经学扫描，以阐明神经和精神疾病的病理生理学。脑生物科学的建立是为了使神经成像变得舒适、廉价并在临床和研究中广泛使用。成像研究中遇到的常见问题之一是正电子发射断层扫描 (PET) 过程中患者的无意移动会降低 PET 图像质量，导致图像伪影，并引入定量误差，这在患有神经系统疾病的患者中尤其常见。随着涉及长时间动态扫描和高分辨率脑成像的研究变得普遍，这个问题变得尤其重要。虽然镇静剂通常用于最大限度地减少患者的运动，但镇静药物会改变大脑。生物化学，干扰放射性药物的吸收，并可能导致副作用。在这个直接阶段，身体束缚常常令人痛苦，并可能增加患者的躁动。 II SBIR 提案，我们寻求开发、临床验证 FREEMotion(tm) 并获得 FDA 批准，这是一种基于视频的头部跟踪系统，无需镇静或物理头枕即可对神经系统患者进行运动补偿大脑正电子发射断层扫描 (PET) 成像。