Administration Core

行政核心

• 批准号: 8236978
• 负责人: Samuel I Miller
• 金额: $ 133.79万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8236978
• 关键词: Bacterial Infections; Biomedical Research; British Columbia; Centers of Research Excellence; Collaborations; Communicable Diseases; Emerging Communicable Diseases; Funding; Geographic Locations; Gram-Negative Bacterial Infections; Idaho; Immune response; Individual; International; Laboratories; Maryland; Mexico; National Institute of Allergy and Infectious Disease; Nature; Oregon; Pathogenesis; Plague; Population; Research; Research Personnel; Site; Staging; Sweden; Thailand; Translations; Tularemia; Universities; Washington; Work; biodefense; combat; member; pathogen; prevent; programs; therapeutic development

The Region X Northwest Regional Center of Excellence (NWRCE) for Biodefense and Emerging Infectious Diseases is an essential component in a nationwide network of biomedical research programs to combat infectious disease threats to the population. The NWRCE is currently a highly interactive and thematic program focused on Gram-negative bacterial pathogens. The same general consistent focus has existed since its inception. There are three themes: (1) mechanisms of Gram-negative bacterial pathogenesis, (2) innate immune responses to Gram-negative bacterial pathogens, and (3) translation of (1) and (2) into early stage therapeutic development to prevent or treat Gram-negative bacterial diseases. The NWRCE is centered at the University of Washington (UW) in Seattle; in this renewal application, multiple sites are proposed in Seattle, two in Oregon, one in Idaho, and one in Maryland. The NWRCE has included the NIAID Rocky Mountain Laboratory since its inception and this relationship will continue and grow as part of this renewal as collaborations are expanded to include tularemia as well as plague research. British Columbia is also in our geographic region and collaboration is proposed with the University of Victoria, British Columbia. The NWRCE renewal proposes three international sites: Thailand, Sweden, and Mexico. The projects, cores, domestic and international sites, as well as collaborators, are highly interactive. The individuals that make up this proposal have worked together for many years during the last funding period and before the RCE was funded. The majority of investigators newly added to this to this application for renewed funding of the NWRCE have had long collaborative relationships with members of the center. The interactive nature and focus of the NWRCE is a major strength of the program and allows the NWRCE to rapidly and nimbly respond to national priorities to achieve important objectives with respect to Gram-negative bacterial infections.

X 区西北生物防御和新兴区域卓越中心 (NWRCE) 传染病是全国生物医学研究网络的重要组成部分 对抗传染病对人口威胁的计划。 NWRCE 目前是一个高度 互动和主题节目重点关注革兰氏阴性细菌病原体。一样的将军 自成立以来一直存在一致的关注点。共有三个主题：（1）革兰氏阴性菌的机制 细菌发病机制，(2) 对革兰氏阴性细菌病原体的先天免疫反应，以及 (3) 将（1）和（2）转化为预防或治疗革兰氏阴性菌的早期治疗开发 细菌性疾病。 NWRCE 以西雅图华盛顿大学 (UW) 为中心；在这次更新中 根据申请，提议在西雅图设立多个站点，在俄勒冈州设立两个站点，在爱达荷州设立一个站点，在马里兰州设立一个站点。这 NWRCE 自 NIAID 落基山实验室成立以来就已将其纳入其中，这种关系将 作为这一更新的一部分，随着合作范围扩大到包括兔热病以及 瘟疫研究。不列颠哥伦比亚省也在我们的地理区域内，建议与 不列颠哥伦比亚省维多利亚大学。 NWRCE 更新提议三个国际站点：泰国、 瑞典、墨西哥。项目、核心、国内外站点以及合作者都高度评价 交互的。构成此提案的个人在过去的几年中共同努力 资助期和 RCE 资助之前。大多数调查人员新添加到此 NWRCE 的续资申请与 NWRCE 的成员有着长期的合作关系 中心。 NWRCE 的互动性质和重点是该计划的主要优势，并允许 NWRCE 快速灵活地响应国家优先事项，以实现以下方面的重要目标： 革兰氏阴性细菌感染。