COMPARISON OF DOBUTAMINE AND REGADENOSON STRESS CMR

多巴酚丁胺和瑞加诺松应激 CMR 的比较

• 批准号: 8167051
• 负责人: William Gregory Hundley
• 金额: $ 0.92万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167051
• 关键词: Asthma; Cardiovascular system; Chronic Obstructive Airway Disease; Computer Retrieval of Information on Scientific Projects Database; Disease; Dobutamine; Enrollment; Funding; Grant; Guidelines; Individual; Institution; Magnetic Resonance Imaging; Motion; Patients; Perfusion; Relative (related person); Research; Research Ethics Committees; Research Personnel; Resources; Schedule; Source; Stress; Stress Tests; United States National Institutes of Health; design

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal is designed to determine the feasibility, staff effort, patient comfort, and false positive rate of implementing a MRI cardiovascular stress perfusion exam with regadenoson (Lexiscan¿?¿) relative to the results obtained during a MRI dobutamine stress wall motion exam. This project will enroll individuals that are scheduled for a dobutamine stress MRI with reactive airways disease (chronic obstructive airway disease or asthma). At our institution this represents 20 ¿?? 25% of patients that are referred for stress testing, or 1 to 2 cases per day. All potential candidates will be contacted in accordance with guidelines approved by the IRB and HIPPA regulatory accords.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以出现在其他 CRISP 条目中 列出的机构是。 对于中心来说，它不一定是研究者的机构。 该提案旨在确定与 MRI 多巴酚丁胺应力室壁运动检查项目中获得的结果相比，使用 regadenoson (Lexiscan??) 实施 MRI 心血管应力灌注检查的可行性、工作人员工作量、患者舒适度和假阳性率。将招募计划接受多巴酚丁胺应激 MRI 治疗的反应性气道疾病（慢性阻塞性气道疾病或哮喘）患者，在我们的机构中​​，这代表 20 ¿ ?? 25% 被转介进行压力测试的患者，或每天 1 至 2 例，将根据 IRB 和 HIPPA 监管协议的批准联系所有潜在候选人。