Multi-Disciplinary Training Program in Translational Cardiovascular Research

转化心血管研究的多学科培训计划

• 批准号: 10117092
• 负责人: William Gregory Hundley
• 金额: $ 36.91万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10117092
• 关键词: Cardiovascular system; Research; Training Programs; multidisciplinary

This program is designed to train post-doctoral physicians and scientists capable of developing new advances in multi-disciplinary translational cardiovascular research directed toward the diagnosis, treatment and prevention of cardiovascular disease (CVD). Worldwide, CVD is the primary cause of morbidity and mortality for those >30 years in age; unfortunately in the US after years of decline, rates of CVD are now increasing in prevalence. This program will help to address the inadequate number of MD and PhD investigators (a shortage recognized by the NHLBI task force review of research training and career development programs) trained in multi-disciplinary CVD research activities that are needed to pursue solutions to reduce the burden of CVD. Our 5-year proposal includes the training of 4 MD applicants for 2 years beginning at the PGY 5 level, and 3 PhD applicants for 3 years beginning at the PGY 0 level. The program builds on research strengths at Virginia Commonwealth University (VCU) involving basic and clinical translational CV science using cellular, small animal, and single and multi-center population cohort and clinical trials. Key features of this proposed T32 training program include: 1) pairing each trainee with an externally funded research mentor whose research focuses on CVD; 2) outstanding multidisciplinary faculty who are experienced in training young investigators and can quickly establish this T32 program for fostering successful progress in academic medicine; 3) access to multiple phenotypic and biologic materials from major NIH-funded basic science, prospective cohort, or clinical trials at VCU through the supporting program faculty; 4) courses provided by the existing graduate school and medical faculty that supplement areas of CV research not previously experienced by trainees; and 5) two institutional seminar programs that enhances interaction among individuals from multiple disciplines. The proposed training program includes 15 faculty from 7 departments; these faculty currently mentor 11 individuals who meet the program eligibility criteria. Each has NIH or VA extramural funding; strong institutional support in the form of financial resources, facilities, and equipment; robust integration with the VCU Center of Health Disparities for recruiting and training minority scientists; and support for key professional development activities such as presentations and grant and manuscript writing. The ultimate goal of this T32 training program is to attract and train a cohort of outstanding academic scientists fluent in the latest developments of CV multidisciplinary translational research, who will then apply this knowledge to design and lead future studies regarding important questions in cardiovascular health. The proposed training program, with an emphasis on training both MD and PhD investigators, would augment the supply of physicians and scientists capable of developing new advances in multi- disciplinary translational cardiovascular research directed toward the treatment and prevention of cardiovascular disease, a major public health issue.

该计划旨在培养能够开发新进展的博士后医生和科学家 从事多学科转化心血管研究，旨在诊断、治疗和 预防心血管疾病（CVD）。在世界范围内，CVD 是发病率和死亡率的主要原因 对于年龄 >30 岁的人；不幸的是，在美国，CVD 发病率经过多年下降后，现在正在上升 流行率。该计划将有助于解决医学博士和博士研究人员数量不足的问题（ NHLBI 特别工作组对研究培训和职业发展计划的审查认可了短缺） 接受过多学科 CVD 研究活动的培训，这些活动是寻求减轻患者负担的解决方案所必需的 化学气相沉积。我们的 5 年提案包括对 4 名 MD 申请者进行为期 2 年的培训，从 PGY 5 级别开始， 3 名博士申请者，从 PGY 0 级别开始，为期 3 年。该计划建立在以下机构的研究优势之上： 弗吉尼亚联邦大学 (VCU) 涉及使用细胞的基础和临床转化 CV 科学， 小动物、单中心和多中心人群队列和临床试验。本提议的主要特点 T32 培训计划包括： 1) 为每位学员配备一位外部资助的研究导师，该导师的研究导师 研究重点是CVD； 2）优秀的多学科师资队伍，在青年培养方面经验丰富 研究人员可以快速建立此 T32 计划，以促进学术的成功进步 药品; 3) 从 NIH 资助的主要基础科学中获得多种表型和生物材料， 前瞻性队列，或通过支持项目教师在弗吉尼亚联邦大学进行的临床试验； 4) 提供的课程 现有的研究生院和医学院，补充了以前没有经历过的CV研究领域 由实习生； 5) 两个机构研讨会项目，旨在加强来自不同国家的个人之间的互动 多个学科。拟议的培训计划包括来自7个系的15名教师；这些教授 目前正在指导 11 名符合该计划资格标准的个人。每个都有 NIH 或 VA 校外 资金;财政资源、设施和设备等强有力的制度支持；强壮的 与弗吉尼亚联邦大学健康差异中心整合，招募和培训少数族裔科学家；和支持 用于关键的专业发展活动，例如演讲、资助和手稿写作。这 T32培养计划的最终目标是吸引和培养一批优秀的学术科学家 熟悉简历多学科转化研究的最新发展，然后将其应用 设计和领导有关心血管健康重要问题的未来研究的知识。这 拟议的培训计划，重点是培训医学博士和博士研究人员， 增加能够在多方面开发新进展的医生和科学家的供应 旨在治疗和预防的学科转化心血管研究 心血管疾病，一个重大的公共卫生问题。