Target Mycobacterium Protein Tyrosine Phosphatase B for Anti-Tuberculosis Agents

用于抗结核药物的靶分枝杆菌蛋白酪氨酸磷酸酶 B

• 批准号: 8089759
• 负责人: Zhong-Yin Zhang
• 金额: $ 40.65万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-26 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8089759
• 关键词: Action Potentials; Active Sites; Adverse effects; Affect; Affinity; Animal Model; Animals; Antibiotics; Antimycobacterial Agents; Antitubercular Agents; Apoptosis; Binding; Cell Adhesion; Cell Wall; Cell membrane; Cell physiology; Cessation of life; Combinatorial Synthesis; Communicable Diseases; Complex; Cytoplasm; Cytosol; Development; Diabetes Mellitus; Drug Delivery Systems; Drug Resistant Tuberculosis; Effectiveness; Energy Metabolism; Enzymes; Etiology; Evaluation; Event; Extreme drug resistant tuberculosis; Family; Genus Mycobacterium; Goals; Human; Immune System Diseases; Immune response; Infection; Interdisciplinary Study; Laboratories; Lead; Libraries; Link; Malignant Neoplasms; Mediating; Metabolism; Microbe; Molecular; Multi-Drug Resistance; Multidrug-Resistant Tuberculosis; Mycobacterium tuberculosis; Nature; Pathogenesis; Phagocytosis; Pharmaceutical Preparations; Phosphoric Monoester Hydrolases; Phosphotyrosine; Phylogenetic Analysis; Play; Population; Post-Translational Protein Processing; Protein Tyrosine Kinase; Protein Tyrosine Phosphatase; Proteins; Proteomics; Public Health; RNA; Regulation; Research; Resistance; Roentgen Rays; Role; Salicylic Acids; Salmonella; Signal Pathway; Signal Transduction; Structure; Therapeutic; Treatment Protocols; Tuberculosis; Tyrosine Phosphorylation; Virulence Factors; Virus; Yersinia; Yersinia yopH protein; abstracting; bactericide; base; cell growth; combat; compliance behavior; design; high throughput screening; human disease; improved; in vivo; inhibitor/antagonist; innovation; inorganic phosphate; interest; macrophage; migration; multidisciplinary; mycobacterial; new therapeutic target; novel; novel therapeutics; pre-clinical; programs; small molecule; tool; tuberculosis treatment; weapons