Using a Biomarker Panel for Detecting Adolescent Depression

使用生物标志物组检测青少年抑郁症

基本信息

  • 批准号:
    7925920
  • 负责人:
  • 金额:
    $ 20万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-08-01 至 2013-01-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Approximately 6% of all U.S. teenagers suffer from clinical depression which is known to result in continued risk for recurrences with persistence of depressive episodes and psychosocial morbidity into adulthood. MDD can have a serious impact on the lives of teens, by way of example: untreated depression is the number one cause of suicide, which is the third leading cause of death among teenagers. Given the magnitude of the problem, the U.S. Preventive Services Task Force, an influential government-appointed medical panel, urged doctors to routinely screen all American teens for depression. Traditional reliance on clinical assessments patient interviews and/or questionnaires for diagnosing MDD in a large population would require a large amount of resource and would be further limited in the frequency of application. Clearly better less subjective tools are needed to increase the caregivers' ability to identify MDD and other mood disorders within populations. Ridge Diagnostics is developing a test panel of blood based biomarkers (cytokines, stress related hormones, neuroendocrine and metabolic proteins) on physiological pathways related to MDD. Our preliminary clinical results suggest that our multiple marker test can effectively classify depressed patients and/or discriminate them from a normal population with a sensitivity of 87% and a specificity of 95%. The need to extend this aid to diagnosis to larger population screen requires quantitative, sensitive multiplex array technology which we are concurrently developing. This SBIR proposal will use Ridge Diagnostics biomarker panel for MDD and real-time detection to develop a minimally invasive, rapid real-time screening bioassay. PUBLIC HEALTH RELEVANCE: Depression (major depressive disorder, MDD) is the most common mental health disorder in the United States among teens and adults. MDD can have a serious impact on the lives of the many teens who suffer from depression. By way of example, untreated depression is the number one cause of suicide, and the third leading cause of death among teenagers. While about 6% of adolescents suffer from depression, between 10 to 15 percent of teenagers have some symptoms of depression at any one time. In addition it is estimated that 15 percent of teens with depression eventually develop bipolar disorder and 30 percent of teens with depression also develop a substance abuse problem. Depressed teens consistently under-report emotional issues to their teachers, family and friends, who often do not recognize the symptoms of depression, risk of suicide or substance abuse. The potential loss in life and productivity is so great, the U.S. Preventive Services Task Force, an influential government-appointed medical panel, urged doctors to routinely screen all American teens for depression. However, the potential economic burden of such a physician driven program is extremely large. Rather than using subjective evaluation tools, we propose to measure multiple analytes in blood as an aid to diagnosing MDD. The SBIR project will develop a cost effective, minimally invasive, rapid screening bioassay using a small volume of blood. An algorithm will be used to quantify the probability that a teen is suffering from MDD.
描述(由申请人提供):大约 6% 的美国青少年患有临床抑郁症,已知这种情况会导致持续复发的风险,并且抑郁发作和社会心理发病率持续到成年。 MDD 会对青少年的生活产生严重影响,例如:未经治疗的抑郁症是自杀的第一大原因,也是青少年死亡的第三大原因。考虑到问题的严重性,美国预防服务工作组(一个有影响力的政府任命的医疗小组)敦促医生定期对所有美国青少年进行抑郁症筛查。传统上依靠临床评估、患者访谈和/或问卷来诊断大量人群的 MDD 需要大量资源,并且应用频率将进一步受到限制。显然,需要更好的、更少主观的工具来提高护理人员识别人群中重度抑郁症和其他情绪障碍的能力。 Ridge Diagnostics 正在开发一种基于血液的生物标志物(细胞因子、应激相关激素、神经内分泌和代谢蛋白)测试组合,与 MDD 相关的生理途径相关。我们的初步临床结果表明,我们的多标志物测试可以有效地将抑郁症患者分类和/或将他们与正常人群区分开来,敏感性为 87%,特异性为 95%。将这种诊断辅助扩展到更大范围的人群筛查的需要需要我们正在开发的定量、灵敏的多重阵列技术。该 SBIR 提案将使用 Ridge Diagnostics 生物标志物组合进行 MDD 和实时检测,以开发微创、快速实时筛查生物测定法。 公共卫生相关性:抑郁症(重度抑郁症,MDD)是美国青少年和成人中最常见的心理健康障碍。 MDD 会对许多患有抑郁症的青少年的生活产生严重影响。举例来说,未经治疗的抑郁症是自杀的第一大原因,也是青少年死亡的第三大原因。虽然大约 6% 的青少年患有抑郁症,但有 10% 至 15% 的青少年在任何时候都会出现一些抑郁症状。此外,据估计,15% 的抑郁症青少年最终会发展为双相情感障碍,30% 的抑郁症青少年还会出现药物滥用问题。抑郁的青少年始终不向老师、家人和朋友报告情绪问题,而他们往往没有意识到抑郁的症状、自杀或药物滥用的风险。生命和生产力的潜在损失是如此之大,美国预防服务工作组(一个有影响力的政府任命的医疗小组)敦促医生定期对所有美国青少年进行抑郁症筛查。然而,这种由医生驱动的计划的潜在经济负担非常大。我们建议不使用主观评估工具,而是测量血液中的多种分析物来辅助诊断 MDD。 SBIR 项目将开发一种使用少量血液的具有成本效益、微创、快速筛选的生物测定法。将使用一种算法来量化青少年患有重度抑郁症的概率。

项目成果

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