Platnesimycin and platencin biosynthesis and engineering in antibacterial drugs

Platnesimycin 和 Platencin 的生物合成及其在抗菌药物中的工程

• 批准号: 8132759
• 负责人: Ben Shen
• 金额: $ 1.49万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-01-06
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8132759
• 关键词: Acids; Anabolism; Anti-Bacterial Agents; Antibiotic Resistance; Antibiotics; Bacteria; Biochemical; Biological Factors; Cause of Death; Cessation of life; Chemistry; Clinic; Clinical; Cloning; Communicable Diseases; Development; Diterpenes; Drug Kinetics; Drug resistance; Elements; Employee Strikes; Engineering; Ensure; Enzymatic Biochemistry; Enzymes; Evaluation; Face; Future; Gene Cluster; Generations; Goals; Grant; Head; Hospitals; Human; In Vitro; Infection; Investigation; Ketolides; Life; Link; Medical; Methods; Microbe; Modeling; Molecular; Mus; Outcome; Pathway interactions; Pharmaceutical Preparations; Production; Property; Public Health; Publishing; Research; Resistance; Running; Shotguns; Specificity; Streptomyces; Structure-Activity Relationship; Terpenes; Terpenoid Biosynthesis Pathway; Therapeutic; Work; analog; antimicrobial; combat; combinatorial; drug resistant bacteria; fatty acid biosynthesis; flexibility; improved; in vivo; member; novel; pathogen; propionamide; public health relevance; resistance mechanism; scaffold