Influence of attention and eye movement signals on population coding in area V4

注意和眼动信号对V4区群体编码的影响

• 批准号: 8423034
• 负责人: MATTHEW A SMITH
• 金额: $ 23.66万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-01-15 至 2014-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8423034
• 关键词: Amblyopia; Animals; Area; Attention; Brain; Brain Diseases; Brain region; Code; Complex; Craniocerebral Trauma; Data; Electrodes; Eye Movements; Feedback; Goals; Impairment; Implant; Individual; Instruction; Knowledge; Lead; Lesion; Macaca; Measures; Medical; Motor; Neurons; Output; Pathway interactions; Patients; Pattern; Photic Stimulation; Physiological; Play; Population; Process; Property; Research; Role; Saccades; Shapes; Signal Transduction; Site; Stimulus; Stroke; Structure; Synapses; Technology; Testing; V4 neuron; Vision; Visual; Visual Cortex; Visual attention; Visual system structure; area V1; area V4; area striata; attentional modulation; base; extracellular; extrastriate visual cortex; frontal eye fields; inferotemporal cortex; insight; receptive field; relating to nervous system; research study; response; transmission process; visual motor

The goal of this project is to understand how populations of neurons in visual cortex integrate diverse types of information provided by synaptic inputs, including eye movement signals and attentional modulation. Much of our understanding of the visual system has been shaped by extracellular recordings from individual neurons In a single visual area. However, in the case of many diseases of the brain (such as amblyopia) and damage to the brain (such as that caused by concussive head trauma) impairment of functioning can not be understood in terms of a deficit in a single, focal region. Furthermore, an understanding of a complex process like visual attention or visual motor function cannot be obtained from recordings of single neurons in a single cortical area. In this project, we will utilize multi-electrode recording technology in one cortical area combined with stimulating and recording In another cortical area to determine how populations of neurons interact within and between brain regions. Specifically, the proposed experiments will employ chronically implanted 100-electrode arrays In macaque visual area V4 In conjunction with stimulation and recording from single electrodes in the frontal eye fields (FEF). Area V4 Is an idea! choice to explore questions of integration because of Its place in the visual hierarchy. It receives input from early visual cortex as well as higher level regions, including FEF. We will begin by measuring the correlation structure within a population of V4 neurons during visual stimulation in order to determine how it differs from the known structure of correlation in primary visual cortex. Once this is complete, we will record simultaneously in FEF and V4 to determine the types of neurons that are connected between these areas, and test the hypothesis that the FEF to V4 pathway plays a role in attentional modulation. Finally, we will stimulate in FEF and record populations of neurons in V4. We expect that FEF input will serve to synchronize groups of V4 neurons, enabling them to provide a more effective input to downstream cortical areas. These experiments will provide crucial insight into how the visual cortex integrates over small regions of space using information about eye movements and attentional modulation to produce behaviorally relevant output.

该项目的目的是了解视觉皮层中神经元的种群如何整合多种类型 突触输入提供的信息，包括眼动信号和注意调制。很多 我们对视觉系统的理解是由个体的细胞外记录来塑造的 单个视觉区域中的神经元。但是，如果大脑的许多疾病（例如弱视）和 对大脑的损害（例如脑震荡头部创伤引起的损害）功能障碍不可能是 从单个焦点区域的赤字中理解。此外，对复杂的理解 诸如视觉注意或视觉运动功能之类的过程无法从单个神经元的录音中获得 一个皮质区域。在这个项目中，我们将在一个皮质区域使用多电极记录技术 结合另一个皮质区域的刺激和记录，以确定神经元的种群 大脑区域内和之间的相互作用。具体而言，提出的实验将长期采用 在猕猴视觉区域V4中植入100个电极阵列与刺激和记录 额眼场（FEF）中的单电极。区域V4是一个主意！选择探索整合问题 由于它在视觉层次结构中的位置。它从早期视觉皮层和更高级别接收输入 包括FEF在内的地区。我们将首先测量V4人群中的相关结构 视觉刺激过程中的神经元，以确定其与已知相关结构的差异 在主要视觉皮层中。完成此操作后，我们将同时记录FEF和V4以确定 这些区域之间连接的神经元的类型，并检验了FEF至V4的假设 途径在注意调制中起作用。最后，我们将刺激FEF并记录 V4中的神经元。我们预计FEF输入将有助于同步V4神经元组，使它们能够 为下游皮质区域提供更有效的输入。这些实验将提供至关重要的见解 使用有关眼动的信息，视觉皮层如何在空间的小区域集成 和注意调制以产生行为相关的输出。