The 6th International Leukocyte Signal Transduction Workshop

第六届国际白细胞信号转导研讨会

• 批准号: 8205423
• 负责人: AMNON ALTMAN
• 金额: $ 0.3万
• 依托单位: LA JOLLA INSTITUTE FOR IMMUNOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8205423
• 关键词: Animal Disease Models; Animal Model; Animals; Area; Autoimmune Diseases; Autoimmunity; Biochemical; Cell model; Cells; Clinical; Collaborations; Commit; Communicable Diseases; Complex; Country; Crete; Developing Countries; Development; Disease; Disease model; Educational workshop; Faculty; Financial Support; Funding; Genes; Grant; Greece; Human; Immune; Immune System Diseases; Immune response; Immune system; Individual; Inflammation; Inflammatory; International; Invaded; Lead; Leukocytes; Microbe; Minority Groups; Molecular; Motivation; Mus; Mutation; National Institute of Allergy and Infectious Disease; Participant; Pathway interactions; Research; Scientist; Series; Signal Pathway; Signal Transduction; Staging; Technology; Time; Work; career; cell type; clinical application; cost; defense response; experience; genetic manipulation; graduate student; insight; meetings; member; new technology; prevent; programs; receptor; symposium

DESCRIPTION (provided by applicant): A proper immune response depends on complex interactions between different leukocytes and other cell types and their soluble products, and on an extensive crosstalk among many receptors, which transduce activation signals leading to induction of cell-specific gene programs, differentiation, proliferation, and acquisition of effector functions. A deregulated immune response can lead to harmful results, the development of autoimmune diseases being a prime example. Aberrant mechanisms that lead to development of inflammation and autoimmunity have been elucidated to a large degree by the genetic manipulation of mice, which led to significant insights into the underlying signaling mechanisms. Thus, genetic alteration of signaling pathways at defined steps can prevent or induce the development of autoimmunity and other immunological diseases. Nevertheless, small scientific meetings that allow intensive interactions and fruitful discussions and, at the same time, bring together scientists working on fundamental aspects of leukocyte signaling pathways and on the clinical implications of these pathways (including relevant disease models) are far and few between. Funds are requested to support an international conference entitled "The 6th International Leukocyte Signal Transduction Workshop" to be held in Crete, Greece, on 6/5-10/11. This is the 6th in a series of similar meetings, which were held since 2000. The program for the upcoming meeting, with ~80-90 anticipated participants, will bring together scientists working on: i) fundamental aspects of leukocyte signaling pathways; ii) animal disease models and clinical implications of these pathways; and iii) relevant cutting edge technologies. The invited faculty consists of ~26 internationally known scientists who are recognized experts in relevant research areas. Scientists at the early, formative stage of their career will be given priority in participation and presentation. The Specific Aims of the Workshop are: 1. Extend and continue five previous, highly productive Leukocyte Signal Transduction Workshops, by focusing on major new discoveries and findings generated since the previous (5th) Workshop. 2. Bring together internationally known scientists, who are experts in leukocyte signal transduction and the disease implications of leukocyte signaling pathways to, e.g., inflammation, autoimmunity, and infectious disease, in order to present and discuss the most up-to-date relevant research. 3. Give scientists at an early stage of their career, i.e., postdoctoral research fellows and graduate students, particularly those representing minority groups or coming from developing countries, an opportunity to present their own work and to benefit from close, one-on-one interactions with leading scientists, thereby providing an educational experience and a motivation to commit themselves to a scientific research career. The Organizers anticipate that this Workshop will provide most up-to-date information on the covered topics, and will stimulate sharing of ideas and collaborations between scientists working on basic aspects of leukocyte signaling and those studying animal or human inflammatory and autoimmune diseases. PUBLIC HEALTH RELEVANCE: Financial support is requested for a conference entitled "The 6th International Leukocyte Signal Transduction Workshop". This Workshop, the 6th in a series of highly productive meetings initiated in 2000, will be held on June 5-10, 2011 in Crete, Greece, and will be attended by ~80-90 participants from different countries, including a distinguished faculty of ~26 internationally known speakers, who are all recognized leaders in their respective areas of research. The central focus of the meeting will be the biochemical and molecular mechanisms through which different cell types in the immune system acquire the ability to mount effective immune defense responses against invading microbes, and how aberrations in these pathways can lead to immune system diseases such as autoimmunity and inflammation. The requested support will mostly be used to defray the costs of meeting registration and subsistence costs, with high priority being given to young scientists and individuals from underrepresented groups.

描述（由申请人提供）：适当的免疫反应取决于不同白细胞和其他细胞类型及其可溶性产物之间的复杂相互作用，以及许多受体之间的广泛串扰，这些受体转导激活信号，从而诱导细胞特异性基因程序，分化、增殖和效应功能的获得。免疫反应失调可能会导致有害结果，自身免疫性疾病的发展就是一个典型的例子。通过对小鼠的基因操作，已经在很大程度上阐明了导致炎症和自身免疫发展的异常机制，这使得人们对潜在的信号传导机制有了重要的了解。因此，信号通路在特定步骤的遗传改变可以预防或诱导自身免疫和其他免疫疾病的发展。然而，能够进行深入互动和富有成效的讨论，同时将研究白细胞信号传导途径的基本方面和这些途径（包括相关疾病模型）的临床意义的科学家聚集在一起的小型科学会议却很少。 请求资金支持将于 2011 年 6 月 5 日至 10 月 10 日在希腊克里特岛举行的题为“第六届国际白细胞信号转导研讨会”的国际会议。这是自 2000 年以来举行的一系列类似会议中的第六次。即将举行的会议计划预计将有 80-90 名与会者，将汇集致力于以下领域的科学家：i) 白细胞信号传导途径的基本方面； ii) 动物疾病模型和这些途径的临床意义； iii) 相关尖端技术。受邀教师由约 26 名国际知名科学家组成，他们是相关研究领域公认的专家。处于职业生涯早期形成阶段的科学家将优先参与和演讲。 研讨会的具体目标是： 1. 重点关注自上一届（第五届）研讨会以来产生的重大新发现和发现，扩展并延续之前五届高效的白细胞信号转导研讨会。 2. 汇聚国际知名科学家，他们是白细胞信号转导和白细胞信号转导通路对炎症、自身免疫和传染病等疾病影响方面的专家，展示和讨论最新的相关研究。 3. 为处于职业生涯早期阶段的科学家（即博士后研究员和研究生，特别是那些代表少数群体或来自发展中国家的科学家）提供展示自己的工作并从密切的一对一交流中受益的机会与顶尖科学家的互动，从而提供教育经验和致力于科学研究事业的动力。 组织者预计本次研讨会将提供有关所涵盖主题的最新信息，并将促进研究白细胞信号传导基本方面的科学家与研究动物或人类炎症和自身免疫性疾病的科学家之间的想法分享和合作。 公共健康相关性：请求为题为“第六届国际白细胞信号转导研讨会”的会议提供财政支持。该研讨会是 2000 年发起的一系列卓有成效的会议中的第六次，将于 2011 年 6 月 5 日至 10 日在希腊克里特岛举行，将有来自不同国家的约 80 至 90 名与会者参加，其中包括来自不同国家的杰出教师。约 26 位国际知名演讲者，他们都是各自研究领域公认的领导者。会议的中心焦点将是免疫系统中不同细胞类型获得针对入侵微生物发起有效免疫防御反应的能力的生化和分子机制，以及这些途径的异常如何导致自身免疫等免疫系统疾病和炎症。所请求的支持将主要用于支付会议注册费用和生活费用，并高度优先考虑年轻科学家和来自代表性不足群体的个人。