The Fourth International Leukocyte Signal Transduction Workshop: Clinical Implica

第四届国际白细胞信号转导研讨会：临床意义

• 批准号: 7278001
• 负责人: AMNON ALTMAN
• 金额: $ 0.5万
• 依托单位: LA JOLLA INSTITUTE FOR IMMUNOLOGY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-15 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7278001
• 关键词: Animal Disease Models; Animal Model; Area; Autoimmune Diseases; Autoimmunity; Biochemical; Cells; Clinical; Collaborations; Commit; Communicable Diseases; Complex; Development; Disease; Disease model; Educational workshop; Faculty; Funding; Genes; Greece; Human; Immune System Diseases; Immune response; Inflammation; Inflammatory; International; Lead; Leukocytes; Motivation; Mus; Mutation; Participant; Pathway interactions; Range; Research; Scientist; Series; Signal Pathway; Signal Transduction; Staging; Students; Technology; Time; Work; career; cell type; clinical application; clinically relevant; experience; genetic manipulation; insight; member; prevent; professor; programs; receptor; symposium

A proper immune response depends on complex interactions between different leukocytes and other cell types and their soluble products, and on an intensive crosstalk among many receptors, which transduce activation signals leading to induction of cell-specific gene programs, differentiation, proliferation, and acquisition of effector functions. A dysregulated immune response can lead to harmful results, the development of autoimmune diseases being a prime example. Aberrant mechanisms that lead to development of inflammation and autoimmunity have been elucidated to a large degree by the genetic manipulation of mice, which led to significant insights into the underlying signaling mechanisms. Thus, genetic alteration of signaling pathways at defined steps can prevent or induce the development of autoimmunity and other immunological diseases. Nevertheless, small scientific meetings that allow intensive interactions and fruitful discussions and, at the same time, bring together scientists working on fundamental aspects of leukocyte signaling pathways and on the clinical implications of these pathways (including relevant disease models) are far and few between. Funds are requested to support an international conference entitled ?The 4th International Leukocyte Signal Transduction Workshop: Clinical Implications of Signaling Pathways? to be held in Rhodes, Greece, between 6/3-8/07. This is the 4th in a series of similar meetings, which were held since 2000. Previous meetings focused exclusively on basic aspects of signal transduction by leukocyte receptors. The upcoming meeting, with ~120 anticipated participants, will represent a significant departure from this focus. The Organizing Committee has drafted this time a program, which brings together scientists working on fundamental aspects of leukocyte signaling and those studying relevant animal disease models and clinical implications of these signaling pathways. In addition, several invited talks will present and discuss relevant cutting edge technologies. The invited faculty consists of 23 internationally known scientists (in addition to the Organizing Committee) who are recognized experts in relevant research areas. Scientists at the early, formative stage of their career will be given priority in participation and presentation. Together, the scientists participating in this Workshop cover different areas of research, which encompass a comprehensive range, from the subcellular, biochemical level of analysis, through whole cell and animal models, and up to clinical applications. The Specific Aims of the Workshop are: 1. Extend and continue three previous, highly productive Leukocyte Signal Transduction Workshops. 2. Bring together internationally known scientists, who are experts in leukocyte signal transduction and the disease implications of leukocyte signaling pathways to, e.g., inflammation, autoimmunity, and infectious disease, in order to present and discuss the most up-to-date relevant research. 3. Give scientists at an early stage of their formative career, i.e., junior faculty members (assistant professors), postdoctoral research fellows and graduate students an opportunity to present and discuss their own ongoing work and to benefit from close, one-on-one interactions with leading scientists, thereby providing an educational experience and a motivation to commit themselves to a clinically relevant scientific research career. The Organizers anticipate that this Workshop will promote sharing of ideas, close interactions and collaborations between scientists working on basic aspects of leukocyte signaling and those studying animal model (or even human) inflammatory and autoimmune diseases.

适当的免疫反应取决于不同白细胞和其他细胞之间复杂的相互作用 类型及其可溶性产物，以及许多受体之间的强烈串扰，这些受体转导 激活信号导致细胞特异性基因程序的诱导、分化、增殖和 效应器功能的获得。免疫反应失调可能会导致有害的结果 自身免疫性疾病的发展就是一个典型的例子。异常机制导致 炎症和自身免疫的发展在很大程度上是通过遗传来解释的 操纵小鼠，这导致对潜在信号机制的深入了解。因此， 在确定的步骤中对信号通路进行遗传改变可以预防或诱导以下疾病的发生： 自身免疫性疾病和其他免疫性疾病。尽管如此，小型科学会议允许 密集的互动和富有成效的讨论，同时将致力于研究的科学家聚集在一起 白细胞信号传导途径的基本方面以及这些途径的临床意义 （包括相关疾病模型）之间相差甚远。 请求资金支持题为“第四届国际白细胞信号”的国际会议 转导研讨会：信号通路的临床意义？将于希腊罗德岛举行， 6/3-8/07 之间。这是自 2000 年以来举行的一系列类似会议中的第四次。 会议专门讨论白细胞受体信号转导的基本方面。这 即将召开的会议预计将有约 120 名与会者参加，这将与这一重点发生重大偏离。 这次组委会起草了一个计划，汇集了致力于研究的科学家 白细胞信号传导的基本方面以及研究相关动物疾病模型和临床的方面 这些信号通路的影响。此外，几场特邀演讲将介绍并讨论相关问题 尖端技术。受邀教师由23位国际知名科学家组成（除了 组委会），他们是相关研究领域公认的专家。早期的科学家们， 他们职业生涯的形成阶段将优先参与和展示。在一起， 参加本次研讨会的科学家涵盖不同的研究领域，其中包括 范围全面，从亚细胞、生化水平的分析，到全细胞和动物 模型，直至临床应用。 研讨会的具体目标是： 1. 扩展并继续之前的三个高效的白细胞信号转导研讨会。 2. 汇聚国际知名科学家，白细胞信号转导和研究专家 白细胞信号通路对炎症、自身免疫等疾病的影响 传染病，以便展示和讨论最新的相关研究。 3. 为处于职业生涯早期阶段的科学家，即初级教员（助理） 教授）、博士后研究员和研究生有机会展示和讨论 他们自己正在进行的工作，并从与领先科学家的密切、一对一的互动中受益，从而 提供教育经验和致力于临床相关的动力 科研事业。 主办方预计本次研讨会将促进思想分享、密切互动和 研究白细胞信号传导基本方面的科学家与研究人员之间的合作 动物模型（甚至人类）炎症和自身免疫性疾病。