STRAW+10: Addressing the Unfinished Agenda of Staging Reproductive Aging - RESUBM

STRAW 10：解决生殖衰老阶段未完成的议程 - RESUBM

• 批准号: 8202368
• 负责人: Sioban D Harlow
• 金额: $ 5.35万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8202368
• 关键词: AIDS/HIV problem; Address; Adopted; Aging; Algorithms; American; Antral; Biological Markers; Body mass index; Bone Resorption; Categories; Child; Child health care; Chronic Disease; Classification; Climacteric; Clinical; Clinical Trials; Consensus; Contraceptive Agents; Data; Decision Making; District of Columbia; Educational workshop; Endocrine; Endocrine System Diseases; Ensure; Fertility; Follicle Stimulating Hormone; Funding; Gender; Gold; Gynecologic Surgical Procedures; Health; Healthcare; Hormones; Human Development; Hypothalamic structure; Institutes; International; Journals; Knowledge; Life; Lipids; Medicine; Menopausal Status; Menopause; Menstruation; Mental Depression; Modeling; Modification; National Institute on Aging; Nomenclature; Outcome; Ovarian; Peer Review; Physiological; Postmenopause; PubMed; Puberty; Publishing; Quality of life; Recommendation; Recording of previous events; Reproductive Medicine; Research; Research Personnel; Research Priority; Risk; Sleep disturbances; Smoke; Societies; Specific qualifier value; Staging; Staging System; Sterility; Symptoms; Syndrome; Time; Translating; United States; Update; Uterine hemorrhage; Woman; Women' s Group; Women' s Health; base; bone; chemotherapy; critical period; experience; healthy aging; hormone therapy; indexing; inhibin B; meetings; middle age; mullerian-inhibiting hormone; multidisciplinary; population based; reproductive; research study; senescence; success; symposium; tool; web site; working group

DESCRIPTION (provided by applicant): We propose a multi-disciplinary symposium "STRAW+10: Addressing the Unfinished Agenda of Staging Reproductive Aging" to update the 2001 Stages of Reproductive Aging Workshop (STRAW) recommendations. The menopausal transition is a period of critical change, including loss of fertility, increased bone resorption, change in lipid profiles and temporal increases in symptoms, sleep disturbances and depression. STRAW proposed nomenclature, a staging system, and menstrual and endocrine criteria to define stages of ovarian aging. It has become the gold standard for characterizing reproductive aging, as the Tanner Stages characterize puberty. In the past decade, understanding of the critical junctures in hypothalamic and ovarian function before and after the final menstrual period and their implications for women's health has advanced considerably. We will convene 30 investigators from key research groups in the United States and worldwide. The specific aims are to refine criteria for the early menopausal transition given new population-based data relating to follicle-stimulating hormone, antral follicle count, anti-mullerian hormone and inhibin-B; to assess how to include women with higher body-mass-index and who smoke in staging algorithms; to provide recommendations regarding staging of women following gynecological surgery, chemotherapy, and hormone therapy and in women with polycystic ovarian syndrome and chronic diseases such as HIV/AIDS; and to assess potential criteria for staging the post-menopause. The Day 1 public scientific sessions will present recent advances and discuss implications of new data for staging. On Day 2, small working groups will propose modifications to the STRAW criteria. Following discussion, final recommendations will be adopted and research priorities defined. The expected outcome will be a set of recommendations for modifying the STRAW criteria that characterize the end stages of reproductive life including their extension to be more broadly applicable to the range of women's experience. Short- and long-term research priorities will be specified including studies needed to replicate and validate proposed criteria as well as to address gaps in knowledge. The meeting, co-sponsored by The North American Menopause Society (NAMS), The American Society for Reproductive Medicine, The International Menopause Society and The Endocrine Society, will be held September 20-21, 2011 prior to the NAMS Annual Meeting in Washington D.C. STRAW+10 recommendations will be presented at the NAMS meeting. A peer-reviewed executive summary will be published simultaneously in the co-sponsors' journals, Climacteric, Menopause, Fertility and Sterility; with a non-technical version published on their websites. The STRAW+10 staging system will facilitate consistent classification of menopausal status, ensuring comparability of research studies and clinical trials. Once specified, a staging system can be developed into a clinical tool to guide assessment of fertility and contraceptive choices, and healthcare decision-making. Funds will be allocated to support participation of 4 trainees/new investigators. PUBLIC HEALTH RELEVANCE: The purpose of this multi-disciplinary 2-day symposium is to organize and synthesize knowledge accumulated during the past decade in order to update the 2001 Stages of Reproductive Aging Workshop (STRAW) model for staging the end of reproductive life in women. We also propose to extend the STRAW recommendations to be more broadly applicable to the range of women's diverse experience of reproductive aging.

描述（由申请人提供）：我们提议举办一次多学科研讨会“STRAW+10：解决生殖衰老阶段未完成的议程”，以更新 2001 年生殖衰老阶段研讨会 (STRAW) 建议。 更年期过渡是一个关键变化时期，包括生育能力丧失、骨吸收增加、血脂变化以及症状暂时增加、睡眠障碍和抑郁。 STRAW 提出了命名法、分期系统以及月经和内分泌标准来定义卵巢衰老的阶段。它已成为表征生殖衰老的黄金标准，就像坦纳阶段表征青春期一样。在过去的十年中，人们对末次月经前后下丘脑和卵巢功能的关键时刻及其对女性健康的影响的了解有了很大的进展。我们将召集来自美国和世界各地主要研究小组的 30 名研究人员。 具体目标是根据与卵泡刺激激素、窦卵泡计数、抗苗勒氏管激素和抑制素 B 相关的新的基于人群的数据，完善早期绝经过渡的标准；评估如何将体重指数较高和吸烟的女性纳入分期算法；就妇科手术、化疗和激素治疗后的妇女以及患有多囊卵巢综合征和艾滋病毒/艾滋病等慢性病的妇女的分期提供建议；并评估绝经后分期的潜在标准。第一天的公共科学会议将介绍最新进展并讨论新数据对分期的影响。第 2 天，小型工作组将提出对 STRAW 标准的修改建议。经过讨论，最终建议将被采纳并确定研究重点。预期成果将是提出一套修改 STRAW 标准的建议，这些标准描述了生殖生命最后阶段的特征，包括将其扩展至更广泛地适用于妇女经历的范围。将明确短期和长期研究重点，包括复制和验证拟议标准以及解决知识差距所需的研究。 该会议由北美更年期协会 (NAMS)、美国生殖医学协会、国际更年期协会和内分泌协会共同主办，将于 2011 年 9 月 20 日至 21 日在华盛顿特区举行的 NAMS 年会之前举行。 STRAW+10 建议将在 NAMS 会议上提出。经同行评审的执行摘要将同时在共同发起者的期刊《Climacteric》、《Menopause》、《Fertility》和《Sterility》上发表；在其网站上发布了非技术版本。 STRAW+10 分期系统将促进更年期状态的一致分类，确保研究和临床试验的可比性。一旦确定，分期系统就可以发展成为临床工具，以指导生育力和避孕选择的评估以及医疗保健决策。将分配资金支持 4 名实习生/新研究者的参与。 公共健康相关性：这次为期 2 天的多学科研讨会的目的是组织和综合过去十年中积累的知识，以更新 2001 年生殖衰老阶段研讨会 (STRAW) 模型，以对女性生殖生命的终结进行分期。我们还建议扩展 STRAW 建议，使其更广泛地适用于女性不同的生殖衰老经历。