U.S./Costa Rica Neuropsychiatric Genetics Research Training Program

美国/哥斯达黎加神经精神遗传学研究培训计划

• 批准号: 7910548
• 负责人: Michael A Escamilla
• 金额: $ 22.26万
• 依托单位: TEXAS TECH UNIVERSITY HEALTH SCIS CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-08 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7910548
• 关键词: Aging; Area; Biological; Bipolar Disorder; Central America; Chronic; Clinical; Clinical assessments; Cognitive; Complement; Costa Rica; Costa Rican; Country; Dementia; Development; Disease; Doctor of Philosophy; Fellowship; Funding; Genetic; Genetic Research; Goals; Grant; Health; Healthcare; Impaired cognition; Knowledge; Life; Longevity; Measures; Medical; Nerve Degeneration; Neurodevelopmental Disorder; Phenotype; Postdoctoral Fellow; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Schizophrenia; Scientist; Students; Testing; Training; Training Programs; Universities; base; experience; high standard; improved; interest; neuroimaging; neuropathology; neuropsychiatry; prevent; programs; psychologic; public health relevance

DESCRIPTION (provided by applicant): Costa Rica has progressed rapidly in the last fifty years and has the highest standard of living in Central America. Despite these gains significant health problems continue to severely impact the country. Of these illnesses, neuropsychiatric/neurodevelopmental disorders such as schizophrenia, bipolar disorder and progressive dementias pose a particular burden. With increasing longevity these illness require progressively greater resources to adequately treat them. Additionally, while health care and its infrastructure has greatly improved, there has not been the same progress in the development of independent sustainable Costa Rica- based research and scientists. This application's goal is to provide funding to continue this very successful program. Although we have been successful in training medical scientists for the University of Costa Rica since the inception of our Fogarty-funded training program in 2002, we have identified needed improvements in several areas and will implement them in the current project: One goal is to provide training for Ph.D students, who will now be fully integrated in the Biomedical Graduate Program and will focus on the genetics of these chronic neurodevelopmental disorders. While their base training will be in genetics, we recognize that genetics is not monolithic but requires knowledge of the biological context. Thus we will also encourage our Ph.D trainees to take advantage of the full range of potential academic programs at our training center and affiliated programs at our university, to complement their genetic training. We will also limit the post doctoral program to training in identifying a variety of phenotypes using the three most needed technological approaches for the research program at the University of Costa Rica and additional training in clinical assessments related to disorders of aging and neurodegeneration. The phenotyping variables of interest are neuroimaging, neuropathology and cognitive testing and clinical experiences will be in measuring and assessing dementias and cognitive declines associated with aging. As new developments in phenotyping related to schizophrenia and bipolar disorder develop, we will also accommodate targeted mini- fellowships for psychiatric and psychologic researchers as well. PUBLIC HEALTH RELEVANCE: We have identified neurodevelopmental disorders as serious, understudied health problems in Costa Rica. One of the biggest impediments to sustainable advances to prevent and treat these illnesses are the lack of Costa Rican Scientist studying these illnesses, especially in the area of genetics. To overcome this problem this grant extends our current Costa Rican Training Program to include the study of the genetics of neurodevelopmental disorders.

描述（由申请人提供）：哥斯达黎加在过去五十年里发展迅速，拥有中美洲最高的生活水平。尽管取得了这些成就，重大的健康问题继续严重影响该国。在这些疾病中，精神分裂症、躁郁症和进行性痴呆等神经精神/神经发育障碍造成了特别的负担。随着寿命的延长，这些疾病需要越来越多的资源来充分治疗。此外，虽然医疗保健及其基础设施得到了极大改善，但哥斯达黎加独立可持续研究和科学家的发展却没有取得同样的进展。该应用程序的目标是提供资金以继续这一非常成功的计划。尽管自 2002 年福格蒂资助的培训计划启动以来，我们在为哥斯达黎加大学培训医学科学家方面取得了成功，但我们已经确定了几个领域需要改进的地方，并将在当前项目中实施这些改进：一个目标是提供为博士生提供培训，他们现在将完全融入生物医学研究生项目，并将重点研究这些慢性神经发育障碍的遗传学。虽然他们的基础训练将是遗传学，但我们认识到遗传学并不是单一的，而是需要生物学背景的知识。因此，我们还将鼓励我们的博士生利用我们培训中心和我们大学附属项目的全方位潜在学术项目，以补充他们的基因培训。我们还将博士后项目限制为使用哥斯达黎加大学研究项目所需的三种最需要的技术方法来识别各种表型的培训，以及与衰老和神经退行性疾病相关的临床评估的额外培训。感兴趣的表型变量是神经影像学、神经病理学和认知测试，临床经验将用于测量和评估与衰老相关的痴呆和认知能力下降。随着与精神分裂症和双相情感障碍相关的表型分析的新进展，我们还将为精神病学和心理学研究人员提供有针对性的小型奖学金。公共卫生相关性：我们已将神经发育障碍确定为哥斯达黎加严重的、尚未得到充分研究的健康问题。预防和治疗这些疾病的可持续进展的最大障碍之一是缺乏研究这些疾病的哥斯达黎加科学家，特别是在遗传学领域。为了克服这个问题，这笔赠款将我们目前的哥斯达黎加培训计划扩展到包括神经发育障碍的遗传学研究。