U.S./Costa Rica Neuropsychiatric Genetics Research Training Program

美国/哥斯达黎加神经精神遗传学研究培训计划

• 批准号: 8521410
• 负责人: Michael A Escamilla
• 金额: $ 21.14万
• 依托单位: TEXAS TECH UNIVERSITY HEALTH SCIS CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-08 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8521410
• 关键词: Aging; Area; Biological; Bipolar Disorder; Central America; Chronic; Clinical; Clinical assessments; Cognitive; Complement; Costa Rica; Costa Rican; Country; Dementia; Development; Disease; Doctor of Philosophy; Fellowship; Funding; Genetic; Genetic Research; Goals; Grant; Health; Healthcare; Impaired cognition; Instruction; Knowledge; Life; Longevity; Measures; Medical; Nerve Degeneration; Neurodevelopmental Disorder; Phenotype; Postdoctoral Fellow; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Schizophrenia; Scientist; Students; Testing; Training; Training Programs; Universities; base; experience; high standard; improved; interest; neuroimaging; neuropathology; neuropsychiatry; prevent; programs; psychologic

Costa Rica has progressed rapidly in the last fifty years and has the highest standard of living in Central America. Despite these gains significant health problems continue to severely impact the country. Of these illnesses, neuropsychiatric/neurodevelopmental disorders such as schizophrenia, bipolar disorder and progressive dementias pose a particular burden. With increasing longevity these illness require progressively greater resources to adequately treat them. Additionally, while health care and its infrastructure has greatly improved, there has not been the same progress in the development of independent sustainable Costa Rica- based research and scientists. This application's goal is to provide funding to continue this very successful program. Although we have been successful in training medical scientists for the University of Costa Rica since the inception of our Fogarty-funded training program in 2002, we have identified needed improvements in several areas and will implement them in the current project: One goal is to provide training for Ph.D students, who will now be fully integrated in the Biomedical Graduate Program and will focus on the genetics of these chronic neurodevelopmental disorders. While their base training will be in genetics, we recognize that genetics is not monolithic but requires knowledge ofthe biological context. Thus we will also encourage our Ph.D trainees to take advantage of the full range of potential academic programs at our training center and affiliated programs at our university, to complement their genetic training. We will also limit the post doctoral program to training in identifying a variety of phenotypes using the three most needed technological approaches for the research program at the University of Costa Rica and additional training in clinical assessments related to disorders of aging and neurodegeneration. The phenotyping variables of interest are neuroimaging, neuropathology and cognitive testing and clinical experiences will be in measuring and assessing dementias and cognitive declines associated with aging. As new developments in phenotyping related to schizophrenia and bipolar disorder develop, we will also accommodate targeted mini- fellowships for psychiatric and psychologic researchers as well. RELEVANCE (See instructions): We have identified neurodevelopmental disorders as serious, understudied health problems in Costa Rica. One ofthe biggest impediments to sustainable advances to prevent and treat these illnesses are the lack of Costa Rican Scientist studying these illnesses, especially in the area of genetics. To overcome this problem this grant extends our current Costa Rican Training Program to include the study ofthe genetics of neurodevelopmental disorders.

哥斯达黎加在过去五十年里发展迅速，拥有中部地区最高的生活水平 美国。尽管取得了这些成就，重大的健康问题继续严重影响该国。其中 疾病、神经精神/神经发育障碍，如精神分裂症、双相情感障碍和 进行性痴呆造成了特殊的负担。随着寿命的延长，这些疾病需要逐渐 更多的资源来充分治疗他们。此外，虽然医疗保健及其基础设施已经极大地 尽管有所改善，但哥斯达黎加独立可持续发展方面并未取得同样的进展—— 基于研究和科学家。该应用程序的目标是提供资金以继续这一非常成功的事业 程序。尽管我们在为哥斯达黎加大学培训医学科学家方面取得了成功 自 2002 年福格蒂资助的培训计划启动以来，我们已经确定了需要改进的地方 并将在当前项目中实施：其中一个目标是为博士提供培训 学生，现在将完全融入生物医学研究生计划，并将专注于 这些慢性神经发育障碍的遗传学。虽然他们的基础训练将是遗传学，但我们 认识到遗传学并不是铁板一块，而是需要了解生物学背景。如此我们也将 鼓励我们的博士生利用我们的全方位潜在学术课程 我们大学的培训中心和附属项目，以补充他们的基因培训。我们也会 将博士后计划限制为使用三种最需要的方法来识别各种表型的培训 哥斯达黎加大学研究计划的技术方法和额外培训 与衰老和神经退行性疾病相关的临床评估。表型变量 兴趣是神经影像学、神经病理学和认知测试，临床经验将用于测量 并评估与衰老相关的痴呆症和认知能力下降。随着新的发展 随着与精神分裂症和双相情感障碍相关的表型的发展，我们还将适应有针对性的迷你 还为精神病学和心理学研究人员提供奖学金。 相关性（参见说明）： 我们已将神经发育障碍确定为哥斯达黎加严重且未被充分研究的健康问题。 预防和治疗这些疾病的可持续进展的最大障碍之一是缺乏 哥斯达黎加科学家研究这些疾病，特别是在遗传学领域。为了克服这个问题 这笔赠款扩展了我们目前的哥斯达黎加培训计划，将遗传学研究纳入其中 神经发育障碍。

项目成果

FTY720-derivatives do not induce FTY720-like lymphopenia.

FTY720 衍生物不会诱导 FTY720 样淋巴细胞减少症。

• 发表时间: 2017-03
• 作者: Segura;Belcher, Troy K;Vidal;Vargas;Perez, Ruth G
• 通讯作者: Perez, Ruth G

The U.S./Costa Rica Neuropsychiatric Genetics Research Training Program Providing advanced training opportunities to Costa Rican neuropsychiatric researchers.

美国/哥斯达黎加神经精神病学遗传学研究培训计划为哥斯达黎加神经精神病学研究人员提供高级培训机会。

• 发表时间: 2012-07
• 作者: Escamilla, Michael;Large, Daniel
• 通讯作者: Large, Daniel

Trans-arterial Onyx Embolization of a Functional Thoracic Paraganglioma.

功能性胸部副神经节瘤的经动脉 Onyx 栓塞术。

• 发表时间: 2015-02
• 作者: Chacón;Rodriguez, Gustavo J;Maud, Alberto;Ramos;Torabi, Alireza;Fitzgerald, Tamara;Akle, Nassim;Cruz Flores, Salvador;Trier, Todd
• 通讯作者: Trier, Todd

Reversible cerebral vasoconstriction syndrome and nonaneurysmal subarachnoid hemorrhage.

可逆性脑血管收缩综合征和非动脉瘤性蛛网膜下腔出血。

• 发表时间: 2014-06
• 作者: Barboza, Miguel A;Maud, Alberto;Rodriguez, Gustavo J
• 通讯作者: Rodriguez, Gustavo J

FTY720 (Fingolimod) reverses α-synuclein-induced downregulation of brain-derived neurotrophic factor mRNA in OLN-93 oligodendroglial cells.

FTY720（芬戈莫德）可逆转 OLN-93 少突胶质细胞中 α-突触核蛋白诱导的脑源性神经营养因子 mRNA 的下调。

• 发表时间: 2017
• 影响因子: 4.7
• 作者: Segura;Yang, Barbara;Vargas;Perez, Ruth G
• 通讯作者: Perez, Ruth G