Motor cortex dysfunction in migraine

偏头痛的运动皮质功能障碍

• 批准号: 8131128
• 负责人: Jing Xiang
• 金额: $ 17.63万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8131128
• 关键词: Acute; Address; Adolescent; Adult; Affect; Antiepileptic Agents; Area; Brain; Child; Childhood; Chronic; Clinical; Data; Detection; Disease; Effectiveness; Epilepsy; Fingers; Frequencies; Functional disorder; Future; Goals; Headache; Human; Incidence; Lead; Life; Location; Magnetism; Magnetoencephalography; Maintenance; Measures; Methodology; Methods; Migraine; Motor; Motor Cortex; Movement; Outcome; Pain; Pathologic; Pharmaceutical Preparations; Play; Prevention; Prophylactic treatment; Reporting; Research; Resolution; Role; Signal Transduction; Solutions; Source; Specific qualifier value; Technology; Testing; Transcranial magnetic stimulation; base; clinical application; disability; effective therapy; experience; improved; innovation; insight; magnetic field; novel; prevent; public health relevance; relating to nervous system

DESCRIPTION (provided by applicant): Pediatric migraine is one of the five most prevalent childhood disorders in the USA, affecting more than 6 million children and adolescents, up to 10% and 28% of each group, respectively. Recent advances in migraine research have demonstrated the cortical dysfunction plays a primary role in the cascade of migraine. To measure these functional, cortical abnormalities in the brain, magnetoencephalography (MEG) may be used to detect and localize functional brain activation with high spatial and temporal resolutions. Importantly, high-frequency brain signals (HFBS, ~2,632 Hz) have recently been found in the human brain. MEG detection of HFBS provides capability far beyond the conventional methods for revealing subtle cortical dysfunction. We hypothesize that MEG can quantitatively and noninvasively assess cortical dysfunction for children with migraine during and between migraine attacks. This hypothesis is based on the following observations: (1) Cortical dysfunction can be quantified and localized with newly developed MEG methods. (2) Increased neuromagnetic activation in 65-150 Hz has been volumetrically localized in the supplementary motor cortex in children with migraine, and (3) Abnormalities of cortical excitability in migraine have been found by using low frequency brain signals (<40 Hz) and MEG. Recent reports have shown that migraine attacks can be treated and/or prevented by normalizing cortical excitability with transcranial magnetic stimulation (TMS), medications and other methods. Building on our experience in pediatric migraine and clinical applications of MEG for more than a decade, we propose to address the following specific aims: (1) Quantify the spatial and spectral alteration of motor cortex excitability in pediatric migraine during migraine attacks with MEG; (2) Determine the spatial, spectral, frequency and temporal abnormalities of movement-evoked magnetic fields (MEFs) between migraine attacks. MEG data will be digitized at 6,000 Hz. Abnormalities of cortical excitability in migraine will be determined by analyzing neuromagnetic spectral power in 0-3,000 Hz at source levels using wavelet-based beamformer. Since MEG has mainly been used in the study of brain activities in low-frequency ranges (< 40 Hz) in migraine in adults, the study of the motor cortex excitability in pediatric migraine with neuromagnetic signals in 0-3,000 Hz is novel. Quantification of the cortical excitability with neuromagnetic spectral and frequency signatures is technically innovative. Although this proposal focuses on motor cortex, the same methodologies can be applied to evaluate other brain areas as well. If successful, abnormalities of cortical excitability can be noninvasively assessed and localized with MEG. Effective methods for treating and preventing migraine attacks may be possible by normalizing cortical excitability with TMS, medication and other methods. Given that HFBS are a new discovery and our MEG methodologies are novel, improved treatment and prevention solutions based on better understanding of the mechanisms of migraine may protect children with migraine from progressing into a chronic condition with significant disability. PUBLIC HEALTH RELEVANCE: Building on recent discoveries that cortical excitability plays a primary role in the cascade of migraine progression and that the brain generates high-frequency brain signals (~2,632 Hz), we propose to use new MEG technology to quantitatively assess cortical dysfunction during acute migraine. This will add significant depth to the scientific understanding of brain activity during migraines and, if successful, may lead to the effective treatment and prevention of migraine headaches through noninvasive normalization or maintenance of cortical excitability.

描述（由申请人提供）：小儿偏头痛是美国五种最常见的儿童疾病之一，影响超过 600 万儿童和青少年，分别占各群体的 10% 和 28%。偏头痛研究的最新进展表明，皮质功能障碍在偏头痛的级联反应中起主要作用。为了测量大脑中的这些功能性皮质异常，脑磁图 (MEG) 可用于以高空间和时间分辨率检测和定位功能性大脑激活。重要的是，最近在人脑中发现了高频脑信号（HFBS，~2,632 Hz）。 HFBS 的 MEG 检测提供的能力远远超出了揭示细微皮质功能障碍的传统方法。我们假设 MEG 可以定量、无创地评估偏头痛儿童在偏头痛发作期间和发作期间的皮质功能障碍。该假设基于以下观察：（1）可以使用新开发的 MEG 方法对皮质功能障碍进行量化和定位。 (2) 65-150 Hz 的神经磁激活增加在体积上定位于偏头痛儿童的辅助运动皮层，以及 (3) 通过使用低频脑信号（<40 Hz）和梅格。最近的报告表明，可以通过经颅磁刺激 (TMS)、药物和其他方法使皮质兴奋性正常化来治疗和/或预防偏头痛发作。基于我们十多年来在小儿偏头痛和 MEG 临床应用方面的经验，我们建议解决以下具体目标：（1）量化 MEG 偏头痛发作期间小儿偏头痛运动皮层兴奋性的空间和频谱变化； (2) 确定偏头痛发作期间运动诱发磁场 (MEF) 的空间、频谱、频率和时间异常。 MEG 数据将以 6,000 Hz 的频率进行数字化。偏头痛中皮质兴奋性的异常将通过使用基于小波的波束形成器分析源水平 0-3,000 Hz 的神经磁频谱功率来确定。由于 MEG 主要用于研究成人偏头痛低频范围（< 40 Hz）的大脑活动，因此利用 0-3,000 Hz 神经磁信号研究儿童偏头痛的运动皮层兴奋性是新颖的。利用神经磁谱和频率特征对皮质兴奋性进行量化在技术上是创新的。尽管该提案侧重于运动皮层，但相同的方法也可用于评估其他大脑区域。如果成功，可以通过 MEG 无创评估和定位皮质兴奋性异常。通过经颅磁刺激、药物和其他方法使皮质兴奋性正常化，可能是治疗和预防偏头痛发作的有效方法。鉴于 HFBS 是一项新发现，并且我们的 MEG 方法是新颖的，基于更好地了解偏头痛机制的改进的治疗和预防解决方案可以保护偏头痛儿童免于发展为导致严重残疾的慢性疾病。 公共健康相关性：基于最近的发现，即皮质兴奋性在偏头痛进展的级联中起主要作用，并且大脑产生高频脑信号（~2,632 Hz），我们建议使用新的 MEG 技术来定量评估偏头痛期间的皮质功能障碍。急性偏头痛。这将大大加深对偏头痛期间大脑活动的科学理解，如果成功，可能会通过无创正常化或维持皮质兴奋性来有效治疗和预防偏头痛。

项目成果

Spatial Heterogeneity of Cortical Excitability in Migraine Revealed by Multifrequency Neuromagnetic Signals.

多频神经磁信号揭示偏头痛皮质兴奋性的空间异质性。

• 发表时间: 2016-06
• 作者: Xiang, Jing;Leiken, Kimberly;Degrauw, Xinyao;Kay, Benjamin;Fujiwara, Hisako;Rose, Douglas F;Allen, Janelle R;Kacperski, Joanne E;O'Brien, Hope L;Kabbouche, Marielle A;Powers, Scott W;Hershey, Andrew D
• 通讯作者: Hershey, Andrew D

Aberrant neuromagnetic activation in the motor cortex in children with acute migraine: a magnetoencephalography study.

急性偏头痛儿童运动皮层异常神经磁激活：脑磁图研究。

• 发表时间: 2012
• 影响因子: 3.7
• 作者: Guo, Xinyao;Xiang, Jing;Wang, Yingying;O'Brien, Hope;Kabbouche, Marielle;Horn, Paul;Powers, Scott W;Hershey, Andrew D
• 通讯作者: Hershey, Andrew D

A Magnetoencephalography Study of Pediatric Interictal Neuromagnetic Activity Changes and Brain Network Alterations Caused by Epilepsy in the High Frequency (80-1000 Hz).

高频（80-1000 Hz）癫痫引起的儿科发作间期神经磁活动变化和脑网络改变的脑磁图研究。

• 发表时间: 2019-03
• 作者: Meng; Lu
• 通讯作者: Lu

Quantification of Interictal Neuromagnetic Activity in Absence Epilepsy with Accumulated Source Imaging.

通过累积源成像对失神癫痫发作间期神经磁活动进行量化。

• 发表时间: 2015-11
• 影响因子: 2.7
• 作者: Xiang, Jing;Tenney, Jeffrey R;Korman, Abraham M;Leiken, Kimberly;Rose, Douglas F;Harris, Elana;Yuan, Weihong;Horn, Paul S;Holland, Katherine;Loring, David W;Glauser, Tracy A
• 通讯作者: Glauser, Tracy A

Accumulated source imaging of brain activity with both low and high-frequency neuromagnetic signals.

使用低频和高频神经磁信号对大脑活动进行累积源成像。

• 发表时间: 2014
• 作者: Xiang, Jing;Luo, Qian;Kotecha, Rupesh;Korman, Abraham;Zhang, Fawen;Luo, Huan;Fujiwara, Hisako;Hemasilpin, Nat;Rose, Douglas F
• 通讯作者: Rose, Douglas F