Molecular Targets COBRE

分子靶标 COBRE

• 批准号: 7895336
• 负责人: Donald M. Miller
• 金额: $ 75.93万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-24 至 2011-09-23
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7895336
• 关键词: Molecular; Targets; COBRE

DESCRIPTION (provided by applicant): The University of Louisville Molecular Targets Center of Biomedical Research Excellence (MT-COBRE) is focused on identification of novel molecular targets for cancer therapy, emphasizing structural biologic approaches for development of novel therapeutics. The overall objective of the MT-COBRE is to recruit and ensure the success of junior investigators who are members of the Molecular Targets Program at the UofL's Brown Cancer Center. We have made considerable progress towards accomplishment of the goals of the original application during the first five year funding period. Four of the original five COBRE scientists have received NIH R01 funding, the fifth was encouraged to pursue other directions. Five outstanding new scientists have taken their places, three of whom have NIH R01 applications under review or being revised for resubmission. We have been quite fortunate, during the initial funding period, to have retained all of the MT-COBRE faculty. We have leveraged the MT-COBRE support to create a set of effective Core Facilities which have significantly enhanced the productivity of the MT-COBRE investigators and other Brown Cancer Center scientists. The renewal application has added a new Core, the Biophysics Core Facility, and deleted a Core which was underutilized, the Proteomics Core Facility. The specific aims of the proposal are to: 1. develop successful independent research careers for each of the principal investigators that will lead to independent R01 grants. 2. develop core facilities that will enhance the research capability of the principal investigators and the other members of the MT program. 3. continue to develop the Molecular Targets Program as a cohesive research program which will enhance collaborative research projects and funding opportunities. 4. develop a nationally and internationally recognized program which will attract the very best graduate students, postdoctoral fellows and additional faculty. 5. make discoveries leading to new and more effective treatments for patients with cancer. During the next funding period, the MT-COBRE will utilize focused recruitment to enhance the scope of the program. Funding of this renewal application is critically important to allow the program to achieve its potential. Based on its current faculty and projected growth during the next funding period, this program is poised to become one of the nation's premiere cancer drug development programs.

描述（由申请人提供）：路易斯维尔大学生物医学卓越研究分子靶点中心 (MT-COBRE) 专注于识别癌症治疗的新型分子靶点，强调用于开发新型疗法的结构生物学方法。 MT-COBRE 的总体目标是招募初级研究人员并确保他们的成功，这些初级研究人员是伦敦大学布朗癌症中心分子目标项目的成员。在第一个五年资助期内，我们在实现最初申请的目标方面取得了相当大的进展。最初的 5 名 COBRE 科学家中，有 4 名获得了 NIH R01 资助，第五名则被鼓励追求其他方向。五位杰出的新科学家接替了他们的位置，其中三人的 NIH R01 申请正在接受审查或正在修改以重新提交。我们非常幸运，在最初的资助期间，保留了 MT-COBRE 的所有教员。我们利用 MT-COBRE 支持创建了一套有效的核心设施，显着提高了 MT-COBRE 研究人员和其他布朗癌症中心科学家的生产力。更新申请添加了一个新的核心，即生物物理学核心设施，并删除了一个未充分利用的核心，即蛋白质组学核心设施。该提案的具体目标是： 1. 为每位主要研究人员发展成功的独立研究生涯，从而获得独立的 R01 资助。 2. 开发核心设施，以提高主要研究者和 MT 项目其他成员的研究能力。 3. 继续将分子目标计划发展为一个有凝聚力的研究计划，这将增强合作研究项目和资助机会。 4. 制定一项国内和国际认可的计划，吸引最优秀的研究生、博士后研究员和其他教师。 5. 做出发现，为癌症患者提供新的、更有效的治疗方法。在下一个资助期内，MT-COBRE 将利用集中招募来扩大该计划的范围。为该续签申请提供资金对于让该计划发挥其潜力至关重要。根据其目前的师资力量和下一个资助期间的预计增长，该项目有望成为美国首屈一指的癌症药物开发项目之一。