Role of TFII-I in Craniofacial Development

TFII-I 在颅面发育中的作用

基本信息

批准号：
7931949
负责人：
DASHZEVEG BAYARSAIHAN
金额：
$ 9.81万
依托单位：
UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-07-01 至 2012-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7931949
关键词：
Accounting Address Affect Alleles Animals Apoptosis Award Binding Sites Branchial arch structure Cell Lineage Cell Proliferation Cells Cephalic Congenital Abnormality Data Defect Development Discipline Disease Embryo Exons Experimental Designs Face Funding Gene Expression Gene Targeting Genes Genetic Genetic Recombination Genetic Transcription Goals Histones Human Independent Scientist Award Knockout Mice Knowledge Learning Mandible Molecular Molecular Biology Molecular Genetics Morphogenesis Mus National Institute of Dental and Craniofacial Research Neural Crest Neural Crest Cell Nucleic Acid Regulatory Sequences Outcome Pathogenesis Pathway interactions Play Primordium Principal Investigator Protein Biochemistry Proteins Proteomics Regulation Regulatory Pathway Research Role Screening procedure Signal Pathway Signal Transduction Signaling Pathway Gene Site Structure System Systems Biology Tissues Training United States National Institutes of Health base career chromatin immunoprecipitation craniofacial insight member migration mutant orofacial programs relating to nervous system transcription factor

项目摘要

DESCRIPTION (provided by applicant): This Independent Scientist Award (K02) application is based on the applicant's recently funded NIH R01 award from NIDCR (DE 017205) for the years of 2006-2010. The parental R01 award entitled "Role of TFII-I in Craniofacial Development" addresses the function of the TFII-I transcription factor in orofacial development. The proposed research presented in the "Research Plan" section of this K02 application does not have significant changes compared with the studies proposed in the original R01 application, except that some progress made since then is incorporated in the preliminary data section of this application. The research approaches and experimental design proposed in the original R01 application are largely based on the applicant's scientific training and expertise in mouse genetics and molecular biology. The applicant fully realizes the importance of multi-discipline in conducting competitive and high quality research, which is essential for a successful scientific career. Therefore, the applicant plans to acquire additional expertise and learn new systems to promote the original proposal to a higher level and extent the principal investigator's scientific expertise in functional screening, protein biochemistry and proteomics, and systems biology. The details and rationale are described in the following section of the candidate's "career developmental plan".

说明（由申请人提供）：本独立科学家奖 (K02) 申请基于申请人最近从 NIDCR (DE 017205) 资助的 2006-2010 年 NIH R01 奖。题为“TFII-I 在颅面发育中的作用”的家长 R01 奖探讨了 TFII-I 转录因子在口面部发育中的功能。本K02申请的“研究计划”部分中提出的拟议研究与原始R01申请中提出的研究相比没有重大变化，只是此后取得的一些进展纳入了本申请的初步数据部分。原始 R01 申请中提出的研究方法和实验设计很大程度上基于申请人在小鼠遗传学和分子生物学方面的科学训练和专业知识。申请人充分认识到多学科在开展有竞争力的高质量研究中的重要性，这对于成功的科学事业至关重要。因此，申请人计划获得更多的专业知识并学习新的系统，以将最初的提案提升到更高的水平，并扩展主要研究者在功能筛选、蛋白质生物化学和蛋白质组学以及系统生物学方面的科学专业知识。详细内容和理由将在候选人“职业发展计划”的以下部分中描述。