Functional microcircuitry underlying sound processing in the primary auditory cor

初级听觉神经中声音处理的功能微电路

基本信息

批准号：
7931019
负责人：
ANTHONY M ZADOR
金额：
$ 18.33万
依托单位：
COLD SPRING HARBOR LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-24 至 2011-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7931019
关键词：
Accounting Acoustic Nerve Acoustic Stimulation Acute Area Auditory Auditory area Auditory system Autistic Disorder Behavior Brain Characteristics Complex Diagnosis Disease Epilepsy Equilibrium Etiology Goals Grant In Vitro Individual Interneurons Investigation Lead Link Mediating Methods Molecular Molecular Profiling Monitor Nervous system structure Neurons Parvalbumins Pattern Physiological Physiology Play Population Positioning Attribute Preparation Process Property Psychiatric therapeutic procedure Rattus Relative (related person)Reporting Rodent Role Schizophrenia Sensory Shapes Slice Synapses Techniques Testing Tinnitus Visual Cortex Work area V1 awake base extrastriate visual cortex improved in vivo inhibitory neuron millisecond nervous system disorder neural circuit neuromechanism neuronal circuitry neuropathology receptive field relating to nervous system response sensory cortex sensory neuroscience sensory stimulus sound therapy development tool

项目摘要

DESCRIPTION (provided by applicant): The long-term goal of our investigations is to understand the functional role of certain neuronal subtypes in the processing of sound in the cortex. Understanding this circuitry is likely to have an impact on the diagnosis and treatment of clinically important cortical neuropathologies, including autism, schizophrenia, tinnitus and epilepsy. Our central hypothesis is that a certain subtype of inhibitory neuron plays an important role in determining how other cortical neurons respond to sound. To achieve our goals, we propose to monitor and perturb the activity of these neurons. In aim 1, we will study this circuit in vitro, substituting electrical for auditory stimulation. In aims 2 and 3 we will study this circuit in vivo, presenting simple sounds and monitoring the responses they elicit in single neurons, and looking at their role in an auditory behavior. If successful, our studies will provide the link between molecular, circuit and functional aspects of sound processing in the auditory system, and will facilitate the development of treatments for psychiatric and neurological diseases. This proposal will test the function of a particular class of cortical neurons implicated in the etiology of clinically important neuropathologies, including autism, schizophrenia, tinnitus and epilepsy. If successful, our studies will lead to improved strategies for diagnosing and treating these and related disorders.

描述（由申请人提供）：我们研究的长期目标是了解某些神经元亚型在皮层声音处理中的功能作用。了解这一回路可能会对临床重要的皮质神经病理学的诊断和治疗产生影响，包括自闭症、精神分裂症、耳鸣和癫痫。我们的中心假设是，抑制性神经元的某种亚型在决定其他皮层神经元如何响应声音方面发挥着重要作用。为了实现我们的目标，我们建议监测和扰乱这些神经元的活动。在目标 1 中，我们将在体外研究该电路，用电刺激代替听觉刺激。在目标 2 和 3 中，我们将在体内研究这个电路，呈现简单的声音并监测它们在单个神经元中引起的反应，并观察它们在听觉行为中的作用。如果成功，我们的研究将提供听觉系统中声音处理的分子、电路和功能方面之间的联系，并将促进精神和神经疾病治疗方法的开发。该提案将测试与临床重要神经病理学病因有关的特定类别皮质神经元的功能，包括自闭症、精神分裂症、耳鸣和癫痫。如果成功，我们的研究将改进诊断和治疗这些疾病及相关疾病的策略。