Appetite Hormones in Binge Eating Disorder

暴食症中的食欲激素

基本信息

批准号：
7831224
负责人：
ALLAN GELIEBTER
金额：
$ 73万
依托单位：
ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-01 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7831224
关键词：
Abdomen Amygdaloid structure Anterior Applications Grants Area Binge Eating Binge eating disorder Biological Body fat Brain Brain imaging Candy Cell Nucleus Consultations Corpus striatum structure Cues Desire for food Diagnosis Distress Eating Eating Behavior Eating Disorders Emotional Employment Opportunities Enrollment Epidemic Food Functional Magnetic Resonance Imaging Functional disorder Funding Hand Height Hippocampus (Brain)Hormones Hunger Ice Individual Ingestion Insula of Reil Intake Laboratories Lateral Lead Magnetic Resonance Imaging Measures Medial Obesity Outcome Overweight Participant Posterior Hypothalamus Prefrontal Cortex Psychometrics Recovery Regulation Relative (related person)Research Resistance Rewards Running Sampling Satiation Scanning Screening procedure Source Specific qualifier value Stimulus Stress Stress Tests Testing Time United States National Institutes of Health Videotape Visual Water Weight base emotional eating improved outcome forecast parent grant psychologic public health relevance relating to nervous system response stressor visual stimulus waist circumference

项目摘要

DESCRIPTION (provided by applicant): This grant proposal is in response to NIH notice NOT-OD-09-058, 'NIH Announces the Availability of Recovery Acts Funds for Competing Revision.' The objective is to study the biological mechanisms regulating food intake under normal conditions and following a stressor in Binge Eating Disorder (BED). We plan to enroll 24 obese subjects (S's) with BED (12m, 12f), 24 obese S's without BED (12m, 12f) and 24 lean S's without BED (12m, 12f). At an initial consultation, S's will undergo recruitment screening and have height, weight, waist circumference, and body fat assessed. On a second day, they will have an abdominal MRI and a physical exam. As part of the parent grant, over two counterbalanced testing days (one in the morning and one in the afternoon), they will have appetite-related hormones measured before and after a test meal followed by a stress test, and multi-item ad libitum meal. The competitive revision component will expand on the appetite response to the stress component: On two additional separate days of testing, fMRI will be used to examine areas of brain activation in response to visual stimuli of high-palatability foods (HPF), compared with low-palatability foods (LPF), and non-foods (NF). On one of these days, the fMRI scan will be preceded by a Socially-Evaluated Cold Pressor Test (SECPT), a stress test in which the participant places one hand in a basin of ice water while being videotaped. On the other day, the scan will follow a control condition, in which the participant places a hand in a basin of warm water. The SECPT and control condition will both be conducted while the participant sits on the scanner table, just prior to scanning. Compared with obese nonBED S's, we expect the obese BED S's to show increased activation in areas associated with planned ingestion (e.g., ventral premotor cortex) and food reward (e.g., medial orbitofrontal cortex [OFC]), and, in the stress condition, increased activation in areas associated with food reward and poor emotional regulation (e.g., ventral amygdala, anterior cingulate). Compared with lean nonBED S's, we expect obese nonBED S's to show increased activation in areas associated with appetitive reward (e.g., medial and lateral OFC, insula, hippocampus, striatum), and decreased brain activation in areas associated with the inhibition of food intake and satiety (e.g., dorsolateral prefrontal cortex, posterior hypothalamus [i.e., ventromedial nucleus]). These differences among groups are expected to be present following the control condition but much more pronounced following the stressor. PUBLIC HEALTH RELEVANCE: The rising obesity epidemic makes it important to study the pathophysiology of Binge Eating Disorder (BED), which occurs in a significant subset of obese individuals. BED is arguably the most common eating disorder, a major source of distress for many overweight individuals, and may be associated with poorer prognosis and resistance to treatment. Currently, the biological substrates and mechanisms underlying BED, including the neural basis and the differences from obesity without BED, are poorly understood. We plan to use brain imaging to observe the brain's responses to visual food stimuli after a laboratory stressor in obese individuals with and without BED and in lean S's without BED. These findings may lead to improved diagnosis and treatment of BED and obesity.

说明（由申请人提供）：本拨款提案是对 NIH 通知 NOT-OD-09-058 的回应，“NIH 宣布恢复法案基金可用于竞争性修订”。目的是研究正常条件下和暴食症 (BED) 应激源下调节食物摄入的生物学机制。我们计划招募 24 名患有 BED 的肥胖受试者 (S)（12m、12f）、24 名没有 BED 的肥胖受试者（12m、12f）和 24 名没有 BED 的瘦 S 受试者（12m、12f）。在初次咨询时，S 将接受招募筛选，并评估身高、体重、腰围和体脂。第二天，他们将进行腹部核磁共振检查和体检。作为家长补助金的一部分，在两个平衡测试日（早上和下午）中，他们将在测试餐前后测量与食欲相关的激素，然后进行压力测试和多项目随意测试一顿饭。竞争性修正部分将扩展食欲对压力部分的反应：在另外两天的单独测试中，功能磁共振成像将用于检查大脑对高适口性食物（HPF）视觉刺激的激活区域，与低适口性食物相比。 -适口性食品（LPF）和非食品（NF）。其中一天，功能磁共振成像扫描之前将进行社会评估冷加压测试（SECPT），这是一种压力测试，参与者将一只手放入一盆冰水中，同时进行录像。另一天，扫描将遵循控制条件，其中参与者将手放入一盆温水中。 SECPT 和控制条件都将在扫描之前、参与者坐在扫描仪台上时进行。与肥胖的非 BED S 相比，我们预计肥胖的 BED S 在与计划摄入（例如，腹侧前运动皮层）和食物奖励（例如，内侧眶额皮层 [OFC]）相关的区域表现出更高的激活，并且在压力条件下，与食物奖励和情绪调节不良相关的区域（例如腹侧杏仁核、前扣带回）的激活增加。与瘦的非 BED S 相比，我们预计肥胖的 nonBED S 会表现出与食欲奖励相关的区域（例如内侧和外侧 OFC、岛叶、海马、纹状体）的激活增加，而与抑制食物摄入和饮食相关的区域的大脑激活减少。饱腹感（例如，背外侧前额皮质、下丘脑后部[即腹内侧核]）。预计各组之间的这些差异在控制条件后会出现，但在压力源后会更加明显。公共健康相关性：肥胖流行率的上升使得研究暴食症 (BED) 的病理生理学变得非常重要，暴食症发生在肥胖个体的一个重要亚群中。暴饮暴食可以说是最常见的饮食失调症，是许多超重个体的主要痛苦来源，并且可能与较差的预后和对治疗的抵抗力有关。目前，人们对于暴饮暴食的生物学基础和机制，包括神经基础以及与无暴饮暴食的肥胖之间的差异，知之甚少。我们计划使用脑成像来观察患有和不患有暴食症的肥胖个体以及不患有暴食症的瘦人在受到实验室压力后大脑对视觉食物刺激的反应。这些发现可能会改善暴食症和肥胖症的诊断和治疗。