Traumatic Brain Injury in Latin America: Lifespan Analysis

拉丁美洲的创伤性脑损伤：寿命分析

• 批准号: 7869542
• 负责人: RANDALL M CHESNUT
• 金额: $ 16.99万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-15 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7869542
• 关键词: Acute; Address; American; Bolivia; Brain Diseases; Brain Injuries; Caring; Characteristics; Clinical Research; Collaborations; Developed Countries; Developing Countries; Development; Discipline; Effectiveness; Environment; Funding; Guidelines; Injury; Latin America; Length of Stay; Literature; Longevity; Medical; Monitor; Observational Study; Outcome; Patient Care; Patients; Population; Protocols documentation; Randomized Controlled Clinical Trials; Randomized Controlled Trials; Recovery of Function; Research; Research Personnel; Research Training; Resources; Role; Structure; System; Technology; Testing; Training; Training Programs; Trauma; Traumatic Brain Injury; Treatment outcome; Variant; base; design; disability; evidence base; improved; investigator training; mortality; neuropsychological; programs; prospective; trauma centers

DESCRIPTION (provided by applicant): The objective of this application is to establish a network of Centers of Excellence within the Latin American Brain Injury Consortium (LABIC) that will, in collaboration with U.S. partners, conduct research and training programs about traumatic brain injury (TBI). Our specific aims are: #1: In a randomized controlled trial in 3 trauma centers in Bolivia, test the effect on outcomes of management of severe TBI guided by information from ICP monitors vs. a standard empiric protocol. #2: In a prospective, observational study in 7 trauma centers in Latin America, test the association between resource availability/medical management and outcomes for patients with severe TBI. #3: Establish a network of research centers with investigators trained and skilled in the design, conduct, and funding of research programs to address TBI and other brain disorders in Latin America. We hypothesize that: #1. Patients with severe TBI whose acute care treatment is managed using ICP monitors will have significantly lower mortality and better neuropsychological and functional recovery at 6 months post-trauma than those whose treatment is managed with the standard protocol. #2. The incorporation of ICP monitoring into the care of patients with severe TBI will minimize secondary complications and decrease length of stay in ICU. #3. The association between treatment and outcomes for patients with severe TBI identified in the randomized trial of ICP monitoring will generalize to the population in the prospective, observational, study. #4. Variations in resource availability and medical management will be significantly associated with mortality and functional recovery for patients with severe TBI, after controlling for patient and injury characteristics. In fulfilling the aims of this project, important research questions will be answered about TBI in an environment of limited resources, aspects of which will generalize to other developing countries as well as to the developed world. Sustainable capacity to conduct research about TBI in Latin America will be established. Within the structure of LABIC, a cadre of professionals will be trained in clinical research who will be equipped to carry out studies that answer questions which are relevant and important to Latin America. These studies will establish a literature base from which Latin American investigators can generate their own guidelines for the treatment of TBI.

描述（由申请人提供）：本申请的目的是在拉丁美洲脑损伤联盟 (LABIC) 内建立一个卓越中心网络，该网络将与美国合作伙伴合作，开展有关创伤性脑损伤的研究和培训计划（创伤性脑损伤）。我们的具体目标是： #1：在玻利维亚 3 个创伤中心进行的一项随机对照试验中，测试以 ICP 监测仪信息与标准经验方案为指导的严重 TBI 管理结果的效果。 #2：在拉丁美洲 7 个创伤中心进行的一项前瞻性观察性研究中，测试了资源可用性/医疗管理与严重 TBI 患者预后之间的关联。 #3：建立一个研究中心网络，其中的研究人员经过培训并具有设计、实施和资助研究项目的技能，以解决拉丁美洲的 TBI 和其他脑部疾病。我们假设：#1。与使用标准方案进行治疗的患者相比，使用 ICP 监测仪进行紧急护理治疗的严重 TBI 患者在创伤后 6 个月的死亡率将显着降低，并且神经心理和功能恢复会更好。 #2.将 ICP 监测纳入严重 TBI 患者的护理中将最大限度地减少继发并发症并缩短 ICU 的住院时间。 #3. ICP 监测随机试验中确定的严重 TBI 患者的治疗与结果之间的关联将推广到前瞻性观察性研究中的人群。 ＃4。在控制患者和损伤特征后，资源可用性和医疗管理的变化将与严重 TBI 患者的死亡率和功能恢复显着相关。为了实现该项目的目标，将在资源有限的环境中回答有关 TBI 的重要研究问题，其中的某些方面将推广到其他发展中国家以及发达国家。将建立拉丁美洲开展 TBI 研究的可持续能力。在 LABIC 的架构内，一批专业人士将接受临床研究方面的培训，他们将有能力开展研究，回答与拉丁美洲相关且重要的问题。这些研究将建立一个文献库，拉丁美洲研究人员可以从中制定自己的 TBI 治疗指南。