Impact of Omega-3 Intake During Pregnancy on Maternal Stress and Infant Outcome

怀孕期间 Omega-3 摄入量对母亲压力和婴儿结局的影响

基本信息

批准号：
7886816
负责人：
Kathryn Elizabeth Keenan
金额：
$ 16.4万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-06 至 2013-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7886816
关键词：
Affect Anxiety Area Attention Behavior Behavioral Brain Cell membrane Child Child Mental Health Chronic stress Cognitive Development Diet Docosahexaenoic Acids Emotional Emotions Erythrocytes Essential Fatty Acids Event Exposure to Family Fatty Acids Fetus Fish Oils Fishes Funding Glucocorticoids Goals Hormonal Hormones Human Hydrocortisone Infant Infant Development Infant Health Inflammatory Response Intake Intervention Laboratories Life Measures Mediating Mental Depression Mental Health Mothers National Institute of Mental Health Neurons Norepinephrine Nutritional Omega-3 Fatty Acids Outcome Patient Self-Report Perinatal Exposure Physiological Pilot Projects Placebos Polyunsaturated Fatty Acids Poverty Pregnancy Pregnant Women Prevention Psychological Stress Psychosocial Stress Randomized Randomized Controlled Trials Recovery Regulation Reporting Research Research Design Research Personnel Risk Rodent Role Signal Transduction Source Stimulus Stress Supplementation System Temperament Testing Time Translational Research Trier Social Stress Test Woman Work base biological adaptation to stress biological systems clinical care cognitive function dietary supplements emotion regulation environmental stressor experience health disparity infant outcome infant temperament inner city innovation maternal stress member neurotransmitter uptake nonhuman primate nutrition offspring prenatal stress programs psychological stressor public health relevance receptor function response stem stressor transmission process

项目摘要

DESCRIPTION (provided by applicant): Pregnant women living in poverty often experience chronic stress, and consequently higher levels of stress hormones. In utero exposure to high levels of stress hormones can negatively affect the developing fetus and later, the infant's capacity for emotion and behavioral regulation. In this proposal we describe a developing program of research designed to reduce the negative impact of prenatal stress on infant health and development via nutritional supplementation of docosahexaenoic acid (DHA) during pregnancy. DHA is a long-chain polyunsaturated fatty acid member of the omega-3 fatty acid family. DHA is found in its highest concentrations in neural cell membranes, affecting receptor function, neurotransmitter uptake, and signal transmission. There is growing evidence that low levels of dietary DHA intake are associated with suboptimal response to stress and that DHA supplementation can modulate stress response. Aims: The goals of the proposed study are to explore whether DHA supplementation during pregnancy is associated with 1) a reduction in maternal perceived stress during pregnancy; 2) a more modulated maternal cortisol response to a stress stimulus during pregnancy, and 3) more optimal regulation of emotion and behavior in the infant. Approach: Sixty-five pregnant women living in inner-city poverty, who consume less than two servings of fish per week, will be randomly assigned to receive 450 mg/daily of DHA or placebo beginning at 16-20 weeks gestation through the end of pregnancy. Perceived stress, pregnancy related stress, stressful life events, anxiety, and depression will be assessed at baseline and at 24, 30, and 36 weeks of pregnancy and at 4 months post-partum. DHA levels will be assessed at baseline and at 36 weeks of pregnancy. Cortisol response to the Trier Social Stress Test will be measured at baseline, 24, and 30 weeks. At 4 months post-partum infant temperament, cognitive development and stress reactivity will be assessed in the laboratory. Investigators: This proposal stems from an NIMH R21 Translational Science Network on prenatal stress and mental health outcomes in the offspring. Three members of that network, Drs. Keenan, Carter, and Glover, are all funded investigators in the area of prenatal stress and child mental health, which is a prioritized area of exploratory research that could directly impact clinical care. They are collaborating on the present application. Innovation: This will be the first randomized controlled study of the effect of DHA supplementation on stress response in pregnant women living in inner-city poverty, and the first study of maternal DHA supplementation on emotion and stress regulation in their infants. Relevance: If DHA supplementation is associated with reductions in perceived stress, more modulated maternal cortisol response to stress, and more optimal emotional and behavioral regulation in the infant, even within the context inner-city poverty, then a comprehensive program of research on the mechanisms by which these associations evolve and the potential for broad-based prevention of poor developmental outcomes among children born to women living in poverty can be launched. PUBLIC HEALTH RELEVANCE: This will be the first study of the effect of essential fatty acid supplementation in pregnant women living in inner-city poverty on the stress response system during pregnancy. If essential fatty acid supplementation is associated with reductions in the experience of stress, more modulated hormonal response to stress, and more optimal regulation of emotion and attention in the infant, even within the context inner-city poverty, then a comprehensive program of research on the role of nutrition on stress during pregnancy can be launched. This study may be the first step toward broad-based prevention of poor developmental outcomes among children born to women living in poverty.

描述（由申请人提供）：生活贫困的孕妇经常承受慢性压力，因此压力荷尔蒙水平较高。在子宫内暴露于高水平的应激激素会对发育中的胎儿以及随后婴儿的情绪和行为调节能力产生负面影响。在本提案中，我们描述了一项正在开发的研究计划，旨在通过怀孕期间补充二十二碳六烯酸 (DHA) 的营养来减少产前压力对婴儿健康和发育的负面影响。 DHA 是 omega-3 脂肪酸家族的长链多不饱和脂肪酸成员。 DHA 在神经细胞膜中的浓度最高，影响受体功能、神经递质摄取和信号传输。越来越多的证据表明，膳食 DHA 摄入量低与压力反应不佳有关，补充 DHA 可以调节压力反应。目的：本研究的目的是探讨怀孕期间补充 DHA 是否与以下因素相关：1) 减少母亲在怀孕期间感受到的压力； 2）母体皮质醇对怀孕期间压力刺激的反应更加调节，3）对婴儿情绪和行为的更优化调节。方法：65 名生活在市中心贫困地区且每周食用鱼量少于两份的孕妇将被随机分配，从妊娠 16-20 周开始直至妊娠结束每天接受 450 毫克 DHA 或安慰剂。怀孕。将在基线以及怀孕 24、30 和 36 周以及产后 4 个月时评估感知压力、怀孕相关压力、压力生活事件、焦虑和抑郁。 DHA 水平将在基线和怀孕 36 周时进行评估。将在基线、24 周和 30 周时测量皮质醇对特里尔社会压力测试的反应。产后 4 个月时，将在实验室评估婴儿的气质、认知发展和压力反应性。调查人员：该提案源自 NIMH R21 转化科学网络，该网络致力于研究产前压力和后代的心理健康结果。该网络的三名成员，博士。基南、卡特和格洛弗都是产前压力和儿童心理健康领域的受资助研究人员，这是可能直接影响临床护理的探索性研究的优先领域。他们正在就本申请进行合作。创新：这将是第一个关于补充 DHA 对生活在城市贫困地区的孕妇压力反应影响的随机对照研究，也是第一个关于母亲补充 DHA 对婴儿情绪和压力调节的研究。相关性：如果补充 DHA 与减少感知压力、更好地调节母亲皮质醇对压力的反应以及婴儿更优化的情绪和行为调节有关，即使是在内城贫困的情况下，那么就需要对其机制进行全面的研究计划通过这些协会的发展，可以发挥广泛预防贫困妇女所生儿童发育不良的潜力。公共健康相关性：这将是第一项研究补充必需脂肪酸对生活在市中心贫困地区的孕妇怀孕期间压力反应系统的影响的研究。如果补充必需脂肪酸与减少压力体验、调节荷尔蒙对压力的反应以及婴儿情绪和注意力的更佳调节有关，即使是在城市贫困的背景下，那么一项综合研究计划营养对怀孕期间压力的作用可以展开。这项研究可能是广泛预防贫困妇女所生儿童发育不良的第一步。