2023 Elastin, Elastic Fibers and Microfibrils Gordon Research Conference and Gordon Research Seminar

2023年弹性蛋白、弹性纤维和微纤维戈登研究会议和戈登研究研讨会

• 批准号: 10754079
• 负责人: DIANNA M MILEWICZ
• 金额: $ 3.01万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10754079
• 关键词: Address; Affect; Aging; American; Aneurysm; Aortic Diseases; Arteries; Biology; Biomedical Engineering; Blood Vessels; COVID-19 pandemic; Chronic Obstructive Pulmonary Disease; Collaborations; Communities; Cutis Laxa; Data; Dedications; Deposition; Development; Diagnosis; Discipline; Disease; Dislocations; Dissection; Elastic Fiber; Elastic Tissue; Elasticity; Elastin; Elastin Fiber; Environment; Eye; Focal Adhesions; Fostering; Genes; Genetic Diseases; Growth and Development function; Hereditary Disease; Human; Learning; Lens Diseases; Ligaments; Loeys-Dietz Syndrome; Lung; Lung diseases; Marfan Syndrome; Mentors; Metabolic; Microfibrils; Molecular; Organ; Participant; Performance; Physiological; Property; Proteins; Pseudoxanthoma Elasticum; Reproducibility; Research; Research Personnel; Role; Science; Scientist; Signal Transduction; Skin; Smooth Muscle Myocytes; Supravalvular aortic stenosis; Syndrome; Systems Analysis; Technology; Tendon structure; Thoracic aorta; Time; Tissues; Translational Research; UV induced; Weill-Marchesani syndrome; Williams Syndrome; Work; arterial tortuosity; bone; career development; crosslink; developmental disease; disease-causing mutation; geleophysic dysplasia; improved; mechanotransduction; meetings; multidisciplinary; multiple omics; novel; resilience; skill acquisition; success; symposium

Project Summary/Abstract Elastin, elastic fibers, and associated microfibrils are particularly abundant in arteries, ligaments, lungs, and skin but are also important in the tendons, eyes, and bone. Elastin is one of the longest-lived proteins in humans. It is deposited and cross-linked during development and growth, and then it remains metabolically stable over a lifetime. Elastin fibers are unique because they provide resilience to dynamic tissues but also elasticity, i.e., they deform under physiological forces and subsequently release stored energy to drive passive recoil. This conference will provide in-depth coverage of elastic tissue biology and will include the following: molecular properties of elastin; elastin and microfibril assembly; role of elastin in regulating cell signaling; mechanosensing of the elastin/microfibril-smooth muscle cell focal adhesions; aging of elastin-containing tissues; multi-omics and other technologies for elastic fiber system analyses; genetic diseases caused by mutations in genes encoding proteins in or associated with elastic fibers; bioengineering of elastic tissues; and translation of research to improve treatment of diseases that disrupt elastin-containing tissues. The aims of the conference are the following: Provide an inclusive environment and time for multidisciplinary and diverse scientists to gather and interact to catalyze research and new collaborations in the elastin biology; Drive translational research and breakthroughs in the diagnosis, management, and treatment of acquired and genetic disorders that involve elastic fibers and microfibrils; Promote the early integration of young scientists from diverse backgrounds into the elastin scientific community; Address issues related to rigor and reproducibility of data in the elastin biology field; Provide information and interaction to drive diversity in elastin-related field and science in general. The 2023 Elastin, Elastic Fibers & Microfibrils Gordon Research Conference will focus on recent novel, unpublished developments in the field and will stimulate discussions, collaborations, and novel hypotheses by participants from diverse disciplines and backgrounds. The accompanying Gordon Research Seminar will provide the trainees in the field a space to interact with established investigators, present their data, and learn new career development skills.

项目概要/摘要 弹性蛋白、弹性纤维和相关的微纤维在动脉、韧带、肺和皮肤中特别丰富 但对于肌腱、眼睛和骨骼也很重要。弹性蛋白是人类寿命最长的蛋白质之一。它 在发育和生长过程中沉积和交联，然后在一段时间内保持代谢稳定 寿命。弹性蛋白纤维是独特的，因为它们不仅为动态组织提供弹性，而且还提供弹性，即，它们 在生理力作用下变形，随后释放储存的能量以驱动被动反冲。这 会议将深入报道弹性组织生物学，并将包括以下内容：分子 弹性蛋白的特性；弹性蛋白和微纤维组装；弹性蛋白在调节细胞信号传导中的作用；机械传感 弹性蛋白/微原纤维平滑肌细胞粘着斑；含有弹性蛋白的组织老化；多组学和 用于弹性纤维系统分析的其他技术；编码基因突变引起的遗传病 弹性纤维中或与弹性纤维相关的蛋白质；弹性组织生物工程；并将研究成果转化为 改善破坏含弹性蛋白组织的疾病的治疗。会议的目标是 如下：为多学科和多样化的科学家提供包容性的环境和时间来聚集和研究 相互作用，促进弹性蛋白生物学的研究和新的合作；推动转化研究和 在获得性和遗传性疾病的诊断、管理和治疗方面取得突破，这些疾病涉及 弹性纤维和微纤维；促进来自不同背景的年轻科学家尽早融入 弹性蛋白科学界；解决与弹性蛋白生物学数据的严谨性和可重复性相关的问题 场地;提供信息和互动，以推动弹性蛋白相关领域和科学的多样性。这 2023 年弹性蛋白、弹性纤维和微原纤维戈登研究会议将重点关注近期未发表的小说 该领域的发展并将激发参与者的讨论、合作和新颖的假设 来自不同学科和背景。伴随的戈登研究研讨会将提供 该领域的受训人员有一个与知名研究人员互动、展示他们的数据并学习新职业的空间 开发技能。