Biomedical Resource Core

生物医学资源核心

• 批准号: 10754083
• 负责人: Evan A. Scott
• 金额: $ 33.07万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10754083
• 关键词: Adoption; Area; Artificial nanoparticles; Biological; Cells; Clinic; Collaborations; Communities; Coupling; Data; Data Analyses; Development; Diagnostic; Disease; Documentation; Dose; Drug Carriers; Ensure; Experimental Designs; Faculty; Formulation; Goals; Health; Health Service Area; Home; Homing; In Vitro; Individual; Institution; International; Kidney; Kidney Diseases; Medicine; Methods; Mission; Molecular; Monitor; Nanotechnology; Nucleic Acids; Oncology; Pharmaceutical Preparations; Phenotype; Protocols documentation; RNA vaccine; Reagent; Reproducibility; Research; Research Personnel; Resources; Safety; Science; Services; Structure; Technology; Therapeutic; Tissues; Traditional Medicine; Universities; Validation; Work; biomedical resource; chemical resource; design; effective therapy; experience; gene function; improved; in vivo; innovation; interest; member; nanocarrier; nanomedicine; nanotherapeutic; physical science; protein function; response; small molecule; success; therapeutic development; tool; vaccine development

SUMMARY-BIOMEDICAL RESOURCE CORE A major unmet challenge in kidney research is the inability of most traditional approaches and methods to harness the complexity of tissue function, structure, and cellular phenotypes. Innovations in nanotechnology provide powerful tools, reagents, and platforms that outperform traditional approaches in several areas of medicine, as clearly shown by stunning successes including mRNA vaccine development and oncology. Nevertheless, these resources are largely untapped by the kidney community and are unavailable in individual labs or institutions. Northwestern University (NU) is home to global leaders and pioneers in nanotechnology housed in the International Institute of Nanomedicine (IIN). During the tenure of the Northwestern O'Brien Kidney Center (NU-GoKIDNEY), we leveraged this unique scientific expertise at NU to establish and optimize services that deploy the power of nanotechnology in the service of kidney researchers in their efforts to develop more effective treatments for kidney diseases. The proposed Core builds on the momentum established through the Core B nanotherapeutic services offered by NU-GoKIDNEY, which includes 1) longstanding commitment to kidney research of nanomedicine leaders at NU who served as Core leaders and members of our Executive committee, 2) demonstrated interest in nanotechnology services by kidney investigators who requested nanotechnology services and submitted P&F proposals focused on nanomedicine solutions. These established services now form the basis of the following Specific Aims: Aim 1 will establish a Biomedical Resource Core to implement a service design for precision targeting of desired payloads to specific cells and sub-regions within the kidney; Aim 2 will establish SOPs and implement internal QA/QC and SOP protocols for all services offered; Aim 3 will ensure national access to resources by multiple mechanisms, that operate in collaboration with the consortium. In summary, the NU- Biomedical Resource Core will harness the power of nanotechnology to advance kidney health and provide an easily accessed portal to Core services for investigators throughout the US.

概要-生物医学资源核心 肾脏研究中一个未解决的主要挑战是大多数传统方法和方法无法 利用组织功能、结构和细胞表型的复杂性。纳米技术的创新 提供强大的工具、试剂和平台，在多个领域优于传统方法 mRNA 疫苗开发和肿瘤学等令人惊叹的成功就清楚地表明了这一点。 然而，这些资源在很大程度上尚未被肾脏界开发，并且个人无法获得 实验室或机构。西北大学 (NU) 是纳米技术领域全球领导者和先驱的所在地 位于国际纳米医学研究所（IIN）。在西北奥布莱恩肾脏任职期间 中心 (NU-GoKIDNEY)，我们利用 NU 独特的科学专业知识来建立和优化服务 利用纳米技术的力量为肾脏研究人员服务，努力开发更多 肾脏疾病的有效治疗方法。拟议的核心建立在通过 NU-GoKIDNEY 提供的核心 B 纳米治疗服务包括 1) 长期承诺 NU 纳米医学领导者的肾脏研究，他们担任核心领导者和执行人员成员 委员会，2) 肾脏研究人员表现出对纳米技术服务的兴趣，他们要求 纳米技术服务并提交了专注于纳米医学解决方案的 P&F 提案。这些建立的 服务现在构成以下具体目标的基础： 目标 1 将建立生物医学资源核心 实施服务设计，将所需有效载荷精确定位到特定小区和子区域 肾脏；目标 2 将为所提供的所有服务建立 SOP 并实施内部 QA/QC 和 SOP 协议； 目标 3 将确保国家通过多种机制获取资源，这些机制与 财团。总之，NU-生物医学资源核心将利用纳米技术的力量 促进肾脏健康，并为整个研究人员提供一个易于访问的核心服务门户 我们。