VANTAGE:Consolidation to create the Vanderbilt Technologies for Advanced Genomics

VANTAGE：整合创建范德比尔特先进基因组学技术

• 批准号: 7935727
• 负责人: JENNIFER A PIETENPOL
• 金额: $ 867.58万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-25 至 2013-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7935727
• 关键词: Acceleration; Aging; Applications Grants; Arts; Basic Science; Biological; Clinical; Collaborations; Core Facility; DNA; DNA Sequence; DNA Sequencing Facility; Development; Direct Costs; Environment; Flow Cytometry; Gap Junctions; Genome; Genomics; Grant; Health; Home environment; Housing; Human; Institution; Laboratories; Microarray Shared Resource; Modernization; Research; Resource Sharing; Resources; Science; Technology; Translating; Universities; improved; medical schools; next generation; repository; square foot

DESCRIPTION (provided by applicant): Recognizing the importance of translating advances in genome science to improved human health, Vanderbilt University School of Medicine has made a commitment to provide state-of-the art laboratory environments and technology through shared resource facilities. To that end, the purpose of this grant application is to optimize an environment conducive to collaboration and acceleration of new biological and clinical discoveries through consolidation of multiple currently physically separate research resources into a centrally located shared resource: VANTAGE (VANderbilt Technologies for Advanced GEnomics). Through complete modernization of an existing 9,316 Net Square Feet of aging, poorly-utilized laboratory space, this proposal will create a physical home for the Genome Technology Core (GTC, a collaborative core for development of next-generation technologies) and BioVU (the Vanderbilt DNA Repository currently housed within the DNA Resources Core), and will enable the consolidation and expansion of four existing core facilities: DNA Resources Core, DNA Sequencing Core, Vanderbilt Microarray Shared Resource (VMSR) and the Flow Cytometry Core. Once renovation is complete, each of these distinct research resources will share collaborative space, thereby creating an institutional nexus of discovery in genomics research by extending and strengthening already successful collaborations. VANTAGE will enable technical synergy, eliminate unnecessary duplication and accelerate discovery in clinical and basic science across the institution. In particular, this renovation will impact over 968 active grants from major Vanderbilt users involving approximately 235 million in annual direct costs.

描述（由申请人提供）：认识到将基因组科学的进步转化为改善人类健康的重要性，范德比尔特大学医学院承诺通过共享资源设施提供最先进的实验室环境和技术。为此，本次拨款申请的目的是通过将多个目前物理上独立的研究资源整合到一个位于中心的共享资源中，优化有利于合作和加速新的生物和临床发现的环境：VANTAGE（范德比尔特先进基因组学技术） 。通过对现有 9,316 净平方英尺老化且利用率低下的实验室空间进行彻底现代化改造，该提案将为基因组技术核心（GTC，下一代技术开发的协作核心）和 BioVU（范德比尔特大学DNA 存储库目前位于 DNA 资源核心内），并将支持四个现有核心设施的整合和扩展：DNA 资源核心、DNA 测序核心、范德比尔特微阵列共享资源 (VMSR) 和流式细胞术核心。一旦改造完成，这些不同的研究资源将共享合作空间，从而通过扩展和加强已经成功的合作，在基因组学研究中建立发现的机构联系。 VANTAGE 将实现技术协同、消除不必要的重复并加速整个机构的临床和基础科学发现。特别是，此次改造将影响范德比尔特主要用户的超过 968 笔活跃赠款，涉及约 2.35 亿美元的年度直接成本。

项目成果

Toxicant-Induced Metabolic Alterations in Lipid and Amino Acid Pathways Are Predictive of Acute Liver Toxicity in Rats.

毒物诱导的脂质和氨基酸途径代谢改变可预测大鼠急性肝毒性。

• 发表时间: 2020-11-04
• 影响因子: 5.6
• 作者: Pannala, Venkat R;Estes, Shanea K;Rahim, Mohsin;Trenary, Irina;O'Brien, Tracy P;Shiota, Chiyo;Printz, Richard L;Reifman, Jaques;Shiota, Masakazu;Young, Jamey D;Wallqvist, Anders
• 通讯作者: Wallqvist, Anders

Assessing Kidney Injury Induced by Mercuric Chloride in Guinea Pigs with In Vivo and In Vitro Experiments.

通过体内和体外实验评估氯化汞引起的豚鼠肾损伤。

• 发表时间: 2023-04-18
• 影响因子: 5.6
• 作者: Goel, Himanshu;Printz, Richard L;Shiota, Chiyo;Estes, Shanea K;Pannala, Venkat;AbdulHameed, Mohamed Diwan M;Shiota, Masakazu;Wallqvist, Anders
• 通讯作者: Wallqvist, Anders

A guide to single-cell RNA sequencing analysis using web-based tools for non-bioinformatician.

面向非生物信息学家的使用基于网络的工具进行单细胞 RNA 测序分析的指南。

• 发表时间: 2023-12-26
• 作者: Yarlagadda, Sagnik;Giorgio, Todd D
• 通讯作者: Giorgio, Todd D

p52 expression enhances lung cancer progression.

p52 表达促进肺癌进展。

• 发表时间: 2018-04-17
• 影响因子: 4.6
• 作者: Saxon, Jamie A;Yu, Hui;Polosukhin, Vasiliy V;Stathopoulos, Georgios T;Gleaves, Linda A;McLoed, Allyson G;Massion, Pierre P;Yull, Fiona E;Zhao, Zhongming;Blackwell, Timothy S
• 通讯作者: Blackwell, Timothy S

Probing Liver Injuries Induced by Thioacetamide in Human In Vitro Pooled Hepatocyte Experiments.

在人体体外混合肝细胞实验中探讨硫代乙酰胺引起的肝损伤。

• 发表时间: 2024-03-13
• 影响因子: 5.6
• 作者: Goel, Himanshu;Printz, Richard L;Pannala, Venkat R;AbdulHameed, Mohamed Diwan M;Wallqvist, Anders
• 通讯作者: Wallqvist, Anders