Collaborative Observational Study of Myopia in COMET Children 2 Clinical Center

COMET儿童近视2临床中心合作观察研究

• 批准号: 7893473
• 负责人: Erik Matthew Weissberg
• 金额: $ 8.28万
• 依托单位: NEW ENGLAND COLLEGE OF OPTOMETRY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7893473
• 关键词: 11 year old; 16 year old; 17 year old; 7 year old; Address; Adolescent; Adult; African American; Age; Blindness; Boston; Child; Clinical; Cohort Studies; Contact Lenses; Cornea; Data; Enrollment; Environmental Risk Factor; Ethnic Origin; Eye; Future; Gender; Glass; Growth; High Prevalence; Hispanics; Hour; Individual; Intervention; Learning; Literature; Measurement; Modeling; Myopia; Observational Study; Occupational; Operative Surgical Procedures; Parents; Participant; Pathology; Physiologic Intraocular Pressure; Population; Predictive Factor; Protocols documentation; Public Health; Refractive Errors; Risk; Risk Factors; Subgroup; Testing; Thick; Time; Vision; Work; base; cohort; follow-up; macula; predictive modeling

DESCRIPTION (provided by applicant): This proposal is for the Boston Clinical Center to continue to annually examine the 102 currently enrolled COSMICC participants (only 8 subjects have been lost to follow-up since enrolled in 1997-98) for an additional 5 years, for a total follow-up period of 14 years following the COSMICC2 protocol. The data collected from this center will be used to address the specific aims described in more detail in the Chair application and summarized briefly here: 1) to use mathematical functions (the Gompertz function and others) to model myopia progression in the 58% of COSMICC subjects whose myopia is still progressing, and to develop predictive models and test hypotheses based on previously identified risk factors (such as age, ethnicity, parental myopia); 2) to test 4 hypotheses related to environmental risk factors for myopia progression and stabilization and axial elongation in this well-characterized cohort of myopes; and 3) to test 3 hypotheses related to the association of oxial elongation and myopia progression with intraocular pressure, central corneal thickness, and macular thickness in COSMICC subjects. The high prevalence of myopia (25% of the US adult population) and its prominence as a public health problem (risk factor for conditions that can cause vision loss and blindness) emphasize the importance of gaining increased understanding of mechanisms underlying progression and eventual stabilization, so that in the future myopia might be limited to low levels. Better understanding of the factors predictive of myopia progression and stabilization also will help guide selection and timing of interventions as well as target those groups that may benefit the most from treatment.

描述（由申请人提供）：该提案要求波士顿临床中心继续每年检查目前登记的 102 名 COSMICC 参与者（自 1997-98 年登记以来，仅 8 名受试者失访），为期额外 5 年，根据 COSMICC2 协议，总共随访 14 年。从该中心收集的数据将用于实现主席申请中更详细描述的具体目标，并在此简要总结：1）使用数学函数（Gompertz 函数和其他函数）来模拟 58% 的 COSMICC 的近视进展情况近视仍在进展的受试者，并根据先前确定的危险因素（例如年龄、种族、父母近视）开发预测模型和测试假设； 2) 在这个特征明确的近视人群中检验与近视进展、稳定和眼轴延长的环境危险因素相关的 4 个假设； 3) 测试 3 个与 COSMICC 受试者眼轴伸长和近视进展与眼压、中央角膜厚度和黄斑厚度相关的假设。近视的高患病率（占美国成年人口的 25%）及其作为公共健康问题（可导致视力丧失和失明的危险因素）的重要性强调了加深对进展和最终稳定机制的了解的重要性，这样未来的近视度数可能会被限制在较低的水平。更好地了解预测近视进展和稳定的因素也将有助于指导干预措施的选择和时机，以及针对那些可能从治疗中受益最大的群体。