FOOD-BASED BIOMARKERS, DIET QUALITY, AND CARDIOMETABOLIC HEALTH

基于食物的生物标志物、饮食质量和心脏代谢健康

基本信息

批准号：
10598569
负责人：
Qi Sun
金额：
$ 51.87万
依托单位：
HARVARD SCHOOL OF PUBLIC HEALTH
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-15 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10598569
关键词：
Acceleration Behavior Therapy Berry Bioinformatics Biological Markers Blood Pressure Blueberries Body Weight C-reactive protein Calibration Cardiometabolic Disease Caring Chemicals Chickens Chronic Disease Citrus Fruit Coronary heart disease Cost Sharing Data Databases Developed Countries Development Diabetes Mellitus Diet Diet Records Dietary Assessment Dietary Intervention Dietary Practices Dietary Questionnaires Disease Dose Eating Education Epidemic Epidemiology Fabaceae Food Foundations Funding Funding Agency Funding Mechanisms Glycosylated hemoglobin A Health Healthy Eating Hispanic Hispanic Community Health Study Hispanic Community Health Study/Study of Latinos Hispanic Populations Hour Human Incidence Individual Intake International Intervention Studies Ireland Knowledge Lead Letters Lettuce - dietary Life Style Link Measurement Measures Meat Metabolic Methodology Molecular Profiling Northern Ireland Nurses&apos Health Study Nutrient Nutritional Nutritional Study Obesity Outcome Participant Patient Self-Report Performance Persons Population Heterogeneity Prevalence Public Health Qi Randomized Recommendation Relative Risks Research Research Personnel Research Project Grants Resources Risk Risk Estimate Risk Marker Sampling Science Series Spinach - dietary Statistical Methods Strawberries Techniques Testing United States Department of Agriculture United States National Institutes of Health Urine Variant Vegetables Woman bean biomarker discovery biomarker identification biomarker validation blood lipid cardiometabolic risk cardiometabolism case control cohort design dietary dietary guidelines disorder risk efficacy evaluation epidemiology study ethnic diversity feeding gut microbiota heart disease risk high risk improved improved outcome indexing innovation men metabolomics molecular marker mortality multi-ethnic novel novel marker nutritional epidemiology precision nutrition preference primary outcome programs prospective randomized trial research and development response secondary outcome social sugar sweetened beverage urinary validation studies

项目摘要

Accurate assessment of human diet is the cornerstone of nutritional epidemiology. Biomarkers that are sensitive and specific to food intake can provide objective information that improves the characterization of diet. Advances in metabolomic profiling techniques now permit the discovery of novel food biomarkers, although, thus far, only a limited number of robust food biomarkers have been identified. This proposal represents major research efforts to significantly accelerate the advances in the research of nutrition and health by conducting three research projects: 1) food biomarker discovery and validation; 2) examination of food biomarkers in relation to cardiometabolic health, with a focus on coronary heart disease (CHD); and 3) evaluating food biomarker-guided precision nutrition to improve diet quality and cardiometabolic health. These complementary, inter-connected projects will be led by an investigator team consisting of researchers in the US, Ireland, and Northern Ireland with expertise in metabolomics, nutritional biomarker research, nutritional and chronic disease epidemiology, bioinformatics, and dietary intervention studies. The proposed projects will be jointly funded, without overlapping jurisdictions, by the NIH/USDA, Health Research Board and Science Foundation Ireland in the Republic of Ireland, and the Health and Social Care R&D Division in Northern Ireland through the unique US-Ireland R&D Partnership Programme. Dr. Lorraine Brennan, an internationally recognized leader in food biomarker discovery and metabolomics, will lead efforts in identifying novel food biomarkers using urine samples through controlled human feeding studies in Ireland. Dr. Qi Sun and his US team will lead efforts in evaluating the performance of food markers in assessing habitual diet among free-living individuals who are participants of the Nurses' Health Studies (NHS) and Hispanic Community Health Study / Study of Latinos (SOL). In addition, the US investigators will use food markers to construct a diet quality score and subsequently examine this score in relation to CHD risk in the NHS and SOL studies. Dr. Jayne Woodside will design food marker-guided precision nutrition guidance and evaluate the efficacy of the dietary guidance on improving diet quality and cardiometabolic health through a randomized intervention study in Ireland (North and South). This proposal will leverage the interdisciplinary expertise of the Trans-Atlantic team, rich resources of multi-ethnic cohorts in the US, and a unique cost-sharing mechanism by multiple funding agencies. This project will facilitate discoveries of novel food markers, provide further evidence that links food markers with CHD risk in US men and women with diverse ethnic background, and demonstrate the utility of incorporating food markers in designing precision nutrition strategies for improving diet and human health. This study has a great potential to advance dietary assessment methodology and the development of more effective dietary interventions to improve cardiometabolic health.

准确评估人类饮食是营养流行病学的基石。对食物摄入敏感且特定的生物标志物可以提供改善饮食特征的客观信息。代谢组学分析技术的进步现在允许发现新的食品生物标志物，尽管迄今为止，仅鉴定了有限数量的可靠食品生物标志物。该提案代表了通过开展三个研究项目来显着加速营养与健康研究进展的重大研究工作：1）食品生物标志物的发现和验证； 2）检查与心脏代谢健康相关的食品生物标志物，重点关注冠心病（CHD）； 3）评估食品生物标志物引导的精准营养，以改善饮食质量和心脏代谢健康。这些互补、相互关联的项目将由一个研究小组领导，该研究小组由来自美国、爱尔兰和北爱尔兰的研究人员组成，他们在代谢组学、营养生物标志物研究、营养和慢性病流行病学、生物信息学和饮食干预研究方面拥有专业知识。拟议的项目将由美国国立卫生研究院/美国农业部、爱尔兰共和国健康研究委员会和爱尔兰科学基金会以及北爱尔兰健康和社会保健研发部门通过独特的美国-爱尔兰研发合作伙伴关系共同资助，不存在重叠管辖权。程序。 Lorraine Brennan 博士是国际公认的食品生物标志物发现和代谢组学领域的领导者，她将在爱尔兰通过受控人类喂养研究，领导利用尿液样本识别新型食品生物标志物的工作。 Qi Sun 博士和他的美国团队将领导评估食品标记物在评估护士健康研究 (NHS) 和西班牙裔社区健康研究/拉丁裔研究 (SOL) 参与者的自由生活个体的习惯饮食方面的表现。）。此外，美国研究人员将使用食品标记来构建饮食质量评分，并随后在 NHS 和 SOL 研究中检查该评分与 CHD 风险的关系。 Jayne Woodside 博士将设计食品标记引导的精准营养指南，并通过在爱尔兰（北部和南部）开展的一项随机干预研究，评估膳食指南对改善饮食质量和心脏代谢健康的功效。该提案将利用跨大西洋团队的跨学科专业知识、美国多种族群体的丰富资源以及多个资助机构独特的成本分摊机制。该项目将促进新型食品标记的发现，提供进一步的证据，将食品标记与不同种族背景的美国男性和女性的冠心病风险联系起来，并展示将食品标记纳入设计改善饮食和人类健康的精准营养策略的效用。这项研究对于推进饮食评估方法和开发更有效的饮食干预措施以改善心脏代谢健康具有巨大的潜力。