Contaminate Removal For Laboratory Pharmaceutical Synthesis

实验室药物合成的污染物去除

基本信息

批准号：
7598857
负责人：
John J Bowser
金额：
$ 12.76万
依托单位：
COMPACT MEMBRANE SYSTEMS, INC.
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-02-09 至 2011-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7598857
关键词：
Address Adoption Adsorption Aluminum Aluminum Oxide Benzophenones Burn injury Calcium Caliber Chemicals Complex Country Delaware Development Devices Economics Educational process of instructing Environmental air flow Ethyl Ether Excision Feeds Felis catus Fiber Fire - disasters Foxes Goals Heating Hexanes Hydrocarbons Individual Industry Laboratories Length Liquid substance Lithium Magnetism Membrane Metals Methods Natural regeneration Nature Nitrogen Operative Surgical Procedures Organic Chemicals Organic Synthesis Organic solvent product Oxidation-Reduction Oxygen Pentanes Performance Pharmacologic Substance Phase Polymers Potassium Procedures Process Production Pump Reaction Reagent Resistance Safety Series Side Sodium Solutions Solvents Stainless Steel Stream Structure Students System Technology Testing Text Time United States Universities Vacuum Vacuum Pumps Water Weight Work base catalyst chemical synthesis commercialization cost design exhaust feeding foot innovation interest laboratory facility molecular sieving news novel pentane polymerization pressure prevent professor programs prototype public health relevance scale up small molecule tetrahydrofuran vapor wasting water vapor

项目摘要

DESCRIPTION (provided by applicant): Most organic pharmaceutical chemical syntheses are done in organic solvents. Oxygen and/or water contaminants in organic solvents will destroy many organic reactants and organometallic reagents and catalysts. As such, the removal of oxygen and water are critical to successful organic synthesis. Unfortunately both oxygen and water are ubiquitous and significant effort must be introduced to both remove oxygen and water and continue to keep them out of the system. Nearly every organic synthesis laboratory in the United States has a system for the removal of oxygen and water from solvents. Laboratories have several special concerns with respect to the purification of solvents. The three major concerns associated with oxygen and water removal from solvents are safety, cost and space considerations. Traditionally, organic solvents have been purified by distillation from reactive metals. This Phase I project will develop a membrane product and process to remove dissolved oxygen and water from reaction solvents and reactants. This concern for oxygen and water is especially true in laboratory synthesis. Compact Membrane Systems, Inc. proposes a novel membrane product and process to address these issues. This membrane will be a composite structure using a novel porous support and novel dense membrane. The process will both remove the oxygen and water and maintain their removal. The membrane system is in principle universal and very low cost. The removal of oxygen and water from representative solvents will be demonstrated. Once the removal of contaminants is completed, enhanced synthesis related to removal of water and oxygen will be demonstrated working with the University of Delaware. Compact Membrane Systems has numerous industrial and university partners which have shown a strong interest in this technology. These partners will be helpful in the Phase I program and subsequent Phase II activity and commercialization. PUBLIC HEALTH RELEVANCE: This project will develop a membrane product and process to remove dissolved oxygen and water from reaction solvents and reactants. The process will both remove the oxygen and water and maintain their removal. The membrane system is in principle universal and very low cost. This development will represent an application of CMS membrane technology that has considerable significance to production costs related to pharmaceutical manufacturing.

描述（由申请人提供）：大多数有机药物化学合成是在有机溶剂中进行的。有机溶剂中的氧和/或水污染物会破坏许多有机反应物以及有机金属试剂和催化剂。因此，去除氧气和水对于有机合成的成功至关重要。不幸的是，氧气和水无处不在，必须付出巨大的努力来去除氧气和水，并继续将它们排除在系统之外。美国几乎每个有机合成实验室都有一个从溶剂中去除氧气和水的系统。实验室在溶剂纯化方面有几个特别关注的问题。与从溶剂中去除氧气和水相关的三个主要问题是安全、成本和空间考虑。传统上，有机溶剂是通过蒸馏活性金属来纯化的。该一期项目将开发一种膜产品和工艺，以去除反应溶剂和反应物中的溶解氧和水。这种对氧气和水的关注在实验室合成中尤其如此。 Compact Membrane Systems, Inc. 提出了一种新型膜产品和工艺来解决这些问题。该膜将是使用新型多孔支撑体和新型致密膜的复合结构。该过程将去除氧气和水并保持它们的去除。该膜系统原则上是通用的并且成本非常低。将演示从代表性溶剂中去除氧气和水。一旦完成污染物的去除，将与特拉华大学合作演示与去除水和氧相关的增强合成。 Compact Membrane Systems 拥有众多工业和大学合作伙伴，他们对此技术表现出了浓厚的兴趣。这些合作伙伴将有助于第一阶段计划以及随后的第二阶段活动和商业化。公共健康相关性：该项目将开发一种膜产品和工艺，以去除反应溶剂和反应物中的溶解氧和水。该过程将去除氧气和水并保持它们的去除。该膜系统原则上是通用的并且成本非常低。这一发展将代表 CMS 膜技术的应用，对药品制造相关的生产成本具有相当大的意义。